Imaging System for Three-Dimensional Mapping of Cerebrocortical Capillary Networks in Vivo

1993 ◽  
Vol 46 (3) ◽  
pp. 293-309 ◽  
Author(s):  
Antal G. Hudetz ◽  
Andrew S. Greene ◽  
Gabriella Fehér ◽  
Derek E. Knuese ◽  
Allen W. Cowley
2013 ◽  
Vol 2013.50 (0) ◽  
pp. 150601-150602
Author(s):  
Hikari ICHISHIMA ◽  
Yudai NAKAYAMA ◽  
Hiroki ISHIDA ◽  
Shunsuke AKIGUCHI ◽  
Tadashi HACHIGA ◽  
...  

eLife ◽  
2016 ◽  
Vol 5 ◽  
Author(s):  
Michael O Breckwoldt ◽  
Julia Bode ◽  
Felix T Kurz ◽  
Angelika Hoffmann ◽  
Katharina Ochs ◽  
...  

Neoangiogenesis is a pivotal therapeutic target in glioblastoma. Tumor monitoring requires imaging methods to assess treatment effects and disease progression. Until now mapping of the tumor vasculature has been difficult. We have developed a combined magnetic resonance and optical toolkit to study neoangiogenesis in glioma models. We use in vivo magnetic resonance imaging (MRI) and correlative ultramicroscopy (UM) of ex vivo cleared whole brains to track neovascularization. T2* imaging allows the identification of single vessels in glioma development and the quantification of neovessels over time. Pharmacological VEGF inhibition leads to partial vascular normalization with decreased vessel caliber, density, and permeability. To further resolve the tumor microvasculature, we performed correlated UM of fluorescently labeled microvessels in cleared brains. UM resolved typical features of neoangiogenesis and tumor cell invasion with a spatial resolution of ~5 µm. MR-UM can be used as a platform for three-dimensional mapping and high-resolution quantification of tumor angiogenesis.


2010 ◽  
Vol 156-157 ◽  
pp. 496-499
Author(s):  
Wen Lei Sun ◽  
Yu Shan Cao ◽  
Wei Sun

This paper took the roller of a new cotton picker as the example, drew its various parts and assemblyed overally in the three-dimensional mapping software environment of UG, imported the models into the virtual reality assembly platform by the interface between UG and VAPlatform, added the virtual hand and carried through the virtual assembly in the virtual scene based on the certain assembly restriction in UG. The paper realized the visualization of the assembly path, offered the foundation for the feasible assembly path, and finally obtained the reasonable assembly process, provided a set of reasonable operation guide for the workers to assemble the cotton pickers.


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