Bioartificial Pancreas: An Update

A U-shaped bioartificial pancreas with rapid glucose-insulin kinetics. In vitro evaluation and kinetic modelling

Diabetes ◽

10.2337/diabetes.33.8.752 ◽

1984 ◽

Vol 33 (8) ◽

pp. 752-761 ◽

Cited By ~ 14

Author(s):

G. Reach ◽

M. Y. Jaffrin ◽

J. F. Desjeux

Keyword(s):

Kinetic Modelling ◽

Bioartificial Pancreas ◽

In Vitro Evaluation ◽

Insulin Kinetics

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Advancements in Assessments of Bio-Tissue Engineering and Viable Cell Delivery Matrices Using Bile Acid-Based Pharmacological Biotechnologies

Nanomaterials ◽

10.3390/nano11071861 ◽

2021 ◽

Vol 11 (7) ◽

pp. 1861

Author(s):

Armin Mooranian ◽

Melissa Jones ◽

Corina Mihaela Ionescu ◽

Daniel Walker ◽

Susbin Raj Wagle ◽

...

Keyword(s):

Tissue Engineering ◽

Viable Cell ◽

Cell Delivery ◽

Artificial Organ ◽

Bioartificial Pancreas ◽

Advantages And Disadvantages ◽

Wide Range ◽

Bioartificial Organs ◽

Significant Interest ◽

Modern Technologies

The utilisation of bioartificial organs is of significant interest to many due to their versatility in treating a wide range of disorders. Microencapsulation has a potentially significant role in such organs. In order to utilise microcapsules, accurate characterisation and analysis is required to assess their properties and suitability. Bioartificial organs or transplantable microdevices must also account for immunogenic considerations, which will be discussed in detail. One of the most characterized cases is the investigation into a bioartificial pancreas, including using microencapsulation of islets or other cells, and will be the focus subject of this review. Overall, this review will discuss the traditional and modern technologies which are necessary for the characterisation of properties for transplantable microdevices or organs, summarizing analysis of the microcapsule itself, cells and finally a working organ. Furthermore, immunogenic considerations of such organs are another important aspect which is addressed within this review. The various techniques, methodologies, advantages, and disadvantages will all be discussed. Hence, the purpose of this review is providing an updated examination of all processes for the analysis of a working, biocompatible artificial organ.

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Superporous agarose scaffolds for encapsulation of adult human islets and human stem‐cell‐derived β cells for intravascular bioartificial pancreas applications

Journal of Biomedical Materials Research Part A ◽

10.1002/jbm.a.37236 ◽

2021 ◽

Author(s):

Rebecca Shaheen ◽

Rachel E. Gurlin ◽

Rebecca Gologorsky ◽

Charles Blaha ◽

Pujita Munnangi ◽

...

Keyword(s):

Stem Cell ◽

Human Islets ◽

Human Stem Cell ◽

Bioartificial Pancreas ◽

Β Cells ◽

Adult Human

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An intravascular bioartificial pancreas device (iBAP) with silicon nanopore membranes (SNM) for islet encapsulation under convective mass transport

Lab on a Chip ◽

10.1039/c7lc00096k ◽

2017 ◽

Vol 17 (10) ◽

pp. 1778-1792 ◽

Cited By ~ 22

Author(s):

Shang Song ◽

Charles Blaha ◽

Willieford Moses ◽

Jaehyun Park ◽

Nathan Wright ◽

...

Keyword(s):

Mass Transport ◽

Cell Density ◽

Porcine Model ◽

Convective Transport ◽

Bioartificial Pancreas ◽

Islet Encapsulation ◽

Nanopore Membranes

The SNM-based iBAP demonstrates viability and functionality at clinically relevant cell density and hemocompatibility under convective transport in a porcine model.

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