Bioengineered Cardiac Tissue Based on Human Stem Cells for Clinical Application

2017 ◽  
pp. 117-146 ◽  
Author(s):  
Monica Jara Avaca ◽  
Ina Gruh
Keyword(s):  
Stem Cells ◽  
Clinical Application ◽  
Cardiac Tissue ◽  
Human Stem Cells

Tuning of major signaling networks (TGF-β, Wnt, Notch and Hedgehog) by miRNAs in human stem cells commitment to different lineages: Possible clinical application

2017 ◽  
Vol 91 ◽  
pp. 849-860 ◽  
Author(s):  
Sedigheh Fekri Aval ◽  
Hajie Lotfi ◽  
Roghayeh Sheervalilou ◽  
Nosratollah Zarghami
Keyword(s):  
Stem Cells ◽  
Clinical Application ◽  
Signaling Networks ◽  
Human Stem Cells

scholarly journals Cryopreservation of Human Stem Cells for Clinical Application: A Review

2011 ◽  
Vol 38 (2) ◽  
pp. 107-123 ◽  
Author(s):  
Charles J. Hunt
Keyword(s):  
Stem Cells ◽  
Clinical Application ◽  
Human Stem Cells

Isolation of human ?stem? cells

Nature ◽  
1998 ◽  
Author(s):  
Henry Gee
Keyword(s):  
Stem Cells ◽  
Human Stem Cells

Testing Human Stem Cells in Primates

2005 ◽  
Vol 35 (16) ◽  
pp. 14
Author(s):  
GUY McKHANN
Keyword(s):  
Stem Cells ◽  
Human Stem Cells

Breakthrough Regenerative Cardiopoietic Stem Cells and Related Technologies in the Field of Cardiovascular Medicine – From Bench to Bedside

2012 ◽  
Vol 7 (1) ◽  
pp. 14
Author(s):  
Christian Homsy ◽  
Keyword(s):  
Stem Cells ◽  
Cell Therapy ◽  
Progenitor Cells ◽  
Cardiac Disease ◽  
Cardiac Tissue ◽  
Cardiac Repair ◽  
Cardiac Diseases ◽  
Cardiac Progenitor Cells ◽  
Biotechnology Company ◽  
Cardiovascular Medicine

The scale of cardiac diseases, and in particular heart failure and acute myocardial infarction, emphasises the need for radically new approaches, such as cell therapy, to address the underlying cause of the disease, the loss of functional myocardium. Stem cell-based therapies, whether through transplanted cells or directing innate repair, may provide regenerative approaches to cardiac diseases by halting, or even reversing, the events responsible for progression of organ failure. Cardio3 BioSciences, a leading Belgian biotechnology company focused on the discovery and development of regenerative and protective therapies for the treatment of cardiac disease, was founded in this context in 2004. The company is developing a highly innovative cell therapy approach based on a platform designed to reprogramme the patient’s own stem cells into cardiac progenitor cells. The underlying rationale behind this approach is that, in order to reconstruct cardiac tissue, stem cells need to be specific to cardiac tissue. The key is therefore to provide cardiac-specific progenitor cells to the failing heart to induce cardiac repair.

Human stem cells transplantation to the subretinal space of the retina in the experiment

2020 ◽  
pp. 259-260
Author(s):  
A.A. Mikaelyan ◽  
◽  
N.L. Sheremet ◽  
A.Y. Andreev ◽  
A.A. Plyukhova ◽  
...  
Keyword(s):  
Stem Cells ◽  
Subretinal Space ◽  
Human Stem Cells ◽  
Stem Cells Transplantation

Quantitative Evaluation of Chromosomal Rearrangements in Primary Gene-Edited Human Stem Cells by Preclinical CAST-Seq

2020 ◽  
Author(s):  
Giandomenico Turchiano ◽  
Geoffroy Andrieux ◽  
Georges Blattner ◽  
Valentina Pennucci ◽  
Julia Klermund ◽  
...  
Keyword(s):  
Stem Cells ◽  
Quantitative Evaluation ◽  
Chromosomal Rearrangements ◽  
Human Stem Cells ◽  
Primary Gene

Opinion on the Ethical Aspects of Patenting Inventions Involving Human Stem Cells

2002 ◽  
Vol 12 (1) ◽  
pp. 43-48
Author(s):  
Bart HANSEN
Keyword(s):  
Stem Cells ◽  
Human Stem Cells ◽  
Ethical Aspects

Adult Stem Cells and Biocompatible Scaffolds as Smart Drug Delivery Tools for Cardiac Tissue Repair

2013 ◽  
Vol 20 (28) ◽  
pp. 3429-3447 ◽  
Author(s):  
Stefania Pagliari ◽  
Sara Romanazzo ◽  
Diogo Mosqueira ◽  
Perpetua Pinto-do-O ◽  
Takao Aoyagi ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Stem Cells ◽  
Tissue Repair ◽  
Adult Stem Cells ◽  
Cardiac Tissue ◽  
Smart Drug ◽  
Smart Drug Delivery

Uncovering the Diversification of Tissue Engineering on the Emergent Areas of Stem Cells, Nanotechnology and Biomaterials

2020 ◽  
Vol 15 (3) ◽  
pp. 187-201 ◽  
Author(s):  
Sunil K. Dubey ◽  
Amit Alexander ◽  
Munnangi Sivaram ◽  
Mukta Agrawal ◽  
Gautam Singhvi ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Stem Cells ◽  
Immune System ◽  
Clinical Application ◽  
Cell Types ◽  
Patient Specific ◽  
Potential Strategy ◽  
Induced Pluripotent ◽  
Treat All ◽  
The Impact

Damaged or disabled tissue is life-threatening due to the lack of proper treatment. Many conventional transplantation methods like autograft, iso-graft and allograft are in existence for ages, but they are not sufficient to treat all types of tissue or organ damages. Stem cells, with their unique capabilities like self-renewal and differentiate into various cell types, can be a potential strategy for tissue regeneration. However, the challenges like reproducibility, uncontrolled propagation and differentiation, isolation of specific kinds of cell and tumorigenic nature made these stem cells away from clinical application. Today, various types of stem cells like embryonic, fetal or gestational tissue, mesenchymal and induced-pluripotent stem cells are under investigation for their clinical application. Tissue engineering helps in configuring the stem cells to develop into a desired viable tissue, to use them clinically as a substitute for the conventional method. The use of stem cell-derived Extracellular Vesicles (EVs) is being studied to replace the stem cells, which decreases the immunological complications associated with the direct administration of stem cells. Tissue engineering also investigates various biomaterials to use clinically, either to replace the bones or as a scaffold to support the growth of stemcells/ tissue. Depending upon the need, there are various biomaterials like bio-ceramics, natural and synthetic biodegradable polymers to support replacement or regeneration of tissue. Like the other fields of science, tissue engineering is also incorporating the nanotechnology to develop nano-scaffolds to provide and support the growth of stem cells with an environment mimicking the Extracellular matrix (ECM) of the desired tissue. Tissue engineering is also used in the modulation of the immune system by using patient-specific Mesenchymal Stem Cells (MSCs) and by modifying the physical features of scaffolds that may provoke the immune system. This review describes the use of various stem cells, biomaterials and the impact of nanotechnology in regenerative medicine.

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