Sleep and Circadian Rhythm Abnormalities in the Pathophysiology of Bipolar Disorder

2010 ◽  
pp. 247-262 ◽  
Author(s):  
Jessica Levenson ◽  
Ellen Frank
Keyword(s):  
Bipolar Disorder ◽  
Circadian Rhythm

The circadian rhythm alterations in childhood bipolar disorder

2012 ◽  
Vol 60 (5) ◽  
pp. S59
Author(s):  
L. Viola
Keyword(s):  
Bipolar Disorder ◽  
Circadian Rhythm

scholarly journals Prevalence of Circadian Rhythm Sleep-Wake Disorders and Associated Factors in Euthymic Patients with Bipolar Disorder

PLoS ONE ◽  
2016 ◽  
Vol 11 (7) ◽  
pp. e0159578 ◽  
Author(s):  
Yoshikazu Takaesu ◽  
Yuichi Inoue ◽  
Akiko Murakoshi ◽  
Yoko Komada ◽  
Ayano Otsuka ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Circadian Rhythm ◽  
Associated Factors ◽  
Sleep Wake Disorders

Correction of depression‐associated circadian rhythm abnormalities is associated with lithium‐response in bipolar disorder

2021 ◽  
Author(s):  
Monica Federoff ◽  
Michael J. McCarthy ◽  
Amit Anand ◽  
Wade H. Berrettini ◽  
Holli Bertram ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Circadian Rhythm ◽  
Lithium Response

scholarly journals Sleep and Circadian Rhythm Disturbance in Remitted Schizophrenia and Bipolar Disorder: A Systematic Review and Meta-analysis

2020 ◽  
Vol 46 (5) ◽  
pp. 1126-1143 ◽  
Author(s):  
Nicholas Meyer ◽  
Sophie M Faulkner ◽  
Robert A McCutcheon ◽  
Toby Pillinger ◽  
Derk-Jan Dijk ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Circadian Rhythm ◽  
Motor Activity ◽  
Sleep Latency ◽  
Total Sleep Time ◽  
Sleep Time ◽  
Mean Difference ◽  
Effect Sizes ◽  
Time In Bed ◽  
Modifiable Factors

Abstract Background Sleep and circadian rhythm disturbances in schizophrenia are common, but incompletely characterized. We aimed to describe and compare the magnitude and heterogeneity of sleep-circadian alterations in remitted schizophrenia and compare them with those in interepisode bipolar disorder. Methods EMBASE, Medline, and PsycINFO were searched for case–control studies reporting actigraphic parameters in remitted schizophrenia or bipolar disorder. Standardized and absolute mean differences between patients and controls were quantified using Hedges’ g, and patient–control differences in variability were quantified using the mean-scaled coefficient of variation ratio (CVR). A wald-type test compared effect sizes between disorders. Results Thirty studies reporting on 967 patients and 803 controls were included. Compared with controls, both schizophrenia and bipolar groups had significantly longer total sleep time (mean difference [minutes] [95% confidence interval {CI}] = 99.9 [66.8, 133.1] and 31.1 [19.3, 42.9], respectively), time in bed (mean difference = 77.8 [13.7, 142.0] and 50.3 [20.3, 80.3]), but also greater sleep latency (16.5 [6.1, 27.0] and 2.6 [0.5, 4.6]) and reduced motor activity (standardized mean difference [95% CI] = −0.86 [−1.22, −0.51] and −0.75 [−1.20, −0.29]). Effect sizes were significantly greater in schizophrenia compared with the bipolar disorder group for total sleep time, sleep latency, and wake after sleep onset. CVR was significantly elevated in both diagnoses for total sleep time, time in bed, and relative amplitude. Conclusions In both disorders, longer overall sleep duration, but also disturbed initiation, continuity, and reduced motor activity were found. Common, modifiable factors may be associated with these sleep-circadian phenotypes and advocate for further development of transdiagnostic interventions that target them.

scholarly journals Agomelatine: Its Role in the Management of Major Depressive Disorder

2012 ◽  
Vol 4 ◽  
pp. CMPsy.S7989 ◽  
Author(s):  
Daniel P. Cardinali ◽  
María F. Vidal ◽  
Daniel E. Vigo
Keyword(s):  
Bipolar Disorder ◽  
Major Depressive Disorder ◽  
Circadian Rhythm ◽  
Depressive Disorder ◽  
Seasonal Affective Disorder ◽  
Rapid Onset ◽  
Depressive Illness ◽  
Melatonin Secretion ◽  
Major Depressive ◽  
Onset Of Action

Circadian rhythm abnormalities, as shown by sleep/wake cycle disturbances, constitute one the most prevalent signs of depressive illness; advances or delays in the circadian phase are documented in patients with major depressive disorder (MDD), bipolar disorder, and seasonal affective disorder (SAD). The disturbances in the amplitude and phase of rhythm in melatonin secretion that occur in patients with depression resemble those seen in chronobiological disorders, thus suggesting a link between disturbed melatonin secretion and depressed mood. Based on this, agomelatine, the first MT1/MT2 melatonergic agonist displaying also 5-HT2C serotonergic antagonism, has been introduced as an antidepressant. Agomelatine has been shown to be effective in several animal models of depression and anxiety and it has beneficial effects in patients with MDD, bipolar disorder, or SAD. Among agomelatine's characteristics are a rapid onset of action and a pronounced effectiveness for correcting circadian rhythm abnormalities and improving the sleep/wake cycle. Agomelatine also improves the 3 functional dimensions of depression—emotional, cognitive, and social—thus aiding in the full recovery of patients to a normal life.

A double‐blind, randomized, placebo‐controlled trial of adjunctive blue‐blocking glasses for the treatment of sleep and circadian rhythm in patients with bipolar disorder

2020 ◽  
Vol 22 (7) ◽  
pp. 739-748 ◽  
Author(s):  
Yuichi Esaki ◽  
Ipei Takeuchi ◽  
Soji Tsuboi ◽  
Kiyoshi Fujita ◽  
Nakao Iwata ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Circadian Rhythm ◽  
Controlled Trial ◽  
Double Blind

The relationship between physical activity, BMI, circadian rhythm, and sleep with cognition in bipolar disorder

2020 ◽  
pp. 1-9
Author(s):  
Jennifer L. Burgess ◽  
Andrew J. Bradley ◽  
Kirstie N. Anderson ◽  
P. Gallagher ◽  
R. Hamish McAllister-Williams
Keyword(s):  
Physical Activity ◽  
Bipolar Disorder ◽  
Circadian Rhythm ◽  
Reaction Time ◽  
Mood State ◽  
Significant Proportion ◽  
Individual Variability ◽  
Cognitive Tasks ◽  
Physical Parameters ◽  
Activity Levels

Abstract Background Cognitive deficits affect a significant proportion of patients with bipolar disorder (BD). Problems with sustained attention have been found independent of mood state and the causes are unclear. We aimed to investigate whether physical parameters such as activity levels, sleep, and body mass index (BMI) may be contributing factors. Methods Forty-six patients with BD and 42 controls completed a battery of neuropsychological tests and wore a triaxial accelerometer for 21 days which collected information on physical activity, sleep, and circadian rhythm. Ex-Gaussian analyses were used to characterise reaction time distributions. We used hierarchical regression analyses to examine whether physical activity, BMI, circadian rhythm, and sleep predicted variance in the performance of cognitive tasks. Results Neither physical activity, BMI, nor circadian rhythm predicted significant variance on any of the cognitive tasks. However, the presence of a sleep abnormality significantly predicted a higher intra-individual variability of the reaction time distributions on the Attention Network Task. Conclusions This study suggests that there is an association between sleep abnormalities and cognition in BD, with little or no relationship with physical activity, BMI, and circadian rhythm.

Circadian Rhythm Sleep-Wake Disorders Predict Shorter Time to Relapse of Mood Episodes in Euthymic Patients With Bipolar Disorder

2018 ◽  
Vol 79 (1) ◽  
pp. 17m11565 ◽  
Author(s):  
Yoshikazu Takaesu ◽  
Yuichi Inoue ◽  
Kotaro Ono ◽  
Akiko Murakoshi ◽  
Kunihiro Futenma ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Circadian Rhythm ◽  
Sleep Wake Disorders ◽  
Time To Relapse

Sleep and Circadian Rhythm Disturbances in Bipolar Disorder

2011 ◽  
Vol 72 (05) ◽  
pp. 724 ◽  
Author(s):  
Flavio Kapczinski ◽  
Benicio N. Frey ◽  
Eduard Vieta
Keyword(s):  
Bipolar Disorder ◽  
Circadian Rhythm

Circadian Rhythm and the Prediction of Relapse in Bipolar Disorder

2018 ◽  
Vol 79 (1) ◽  
pp. 17com11821
Author(s):  
Robert Gonzalez ◽  
Mauricio Tohen
Keyword(s):  
Bipolar Disorder ◽  
Circadian Rhythm ◽  
Prediction Of Relapse
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