Inactivation of ID-1 Gene Induces Sensitivity of Prostate Cancer Cells to Chemotherapeutic Drugs

2008 ◽  
pp. 565-572 ◽  
Author(s):  
Yong-Chuan Wong ◽  
Xiao-Meng Zhang ◽  
Ming-Tak Ling ◽  
Xiang-Hong Wang
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Chemotherapeutic Drugs ◽  
Prostate Cancer Cells

scholarly journals Sensitivity of human prostate cancer cells to chemotherapeutic drugs depends on EndoG expression regulated by promoter methylation

2008 ◽  
Vol 270 (1) ◽  
pp. 132-143 ◽  
Author(s):  
Xiaoying Wang ◽  
Volodymyr Tryndyak ◽  
Eugene O. Apostolov ◽  
Xiaoyan Yin ◽  
Sudhir V. Shah ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Promoter Methylation ◽  
Human Prostate ◽  
Chemotherapeutic Drugs ◽  
Human Prostate Cancer ◽  
Prostate Cancer Cells

KLK5 gene expression is severely upregulated in androgen-independent prostate cancer cells after treatment with the chemotherapeutic agents docetaxel and mitoxantrone

2010 ◽  
Vol 391 (4) ◽  
Author(s):  
Konstantinos Mavridis ◽  
Maroulio Talieri ◽  
Andreas Scorilas
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Chemotherapeutic Agents ◽  
Chemotherapeutic Drugs ◽  
Quantitative Real Time Pcr ◽  
Prostate Cancer Cells ◽  
Diagnosis And Prognosis ◽  
Mtt Method ◽  
Du145 Cells ◽  
Hormone Refractory

AbstractKallikrein-related peptidases (KLKs), includingKLK5, have been proposed as promising biomarkers for prostate cancer diagnosis and prognosis. In the present study, we report that distinct augmentations (up to 6.4-fold) ofKLK5mRNA expressional levels, calculated via quantitative real-time PCR, occur after treatment of DU145 cells with appropriate concentrations, determined by the MTT method, of docetaxel and mitoxantrone. Our data reveal the endogenous need of prostate cancer cells for modifiedKLK5expression to cope with the administration of chemotherapeutic drugs. Furthermore, it is proposed that the expression profile ofKLK5could serve as a putative biomarker for monitoring the treatment response in hormone refractory prostate cancer patients.

scholarly journals Loading of piperlongumine to liposomes after complexation with ß- cyclodextrin and its effect on viability of colon and prostate cancer cells

2018 ◽  
Author(s):  
Kalana W. Jayawardana ◽  
Nidhi Jyotsana ◽  
Zhenjiang Zhang ◽  
Michael R. King
Keyword(s):  
Prostate Cancer ◽  
Sustained Release ◽  
Cancer Cells ◽  
Cell Lines ◽  
The Body ◽  
Chemotherapeutic Drugs ◽  
Prostate Cancer Cells ◽  
Water Insoluble Drug

AbstractUse of nano carriers to treat cancer is attractive due to their advantages such as the sustained release of drugs and ability to target specific regions of the body where treatment is needed. However, loading water insoluble chemotherapeutic drugs into liposomes is challenging. In this study, we developed a method to encapsulate water-insoluble drug (piperlongumine) in liposomes by complexing piperlongumine with ß-Cyclodextrin. Liposomes encapsulated with piperlongumine incubated with COLO 205 and PC-3 cell lines and demonstrated that viability of COLO 205 and PC-3 cells decreases to 7% and 41% respectively when the piperlongumine concentration is at 20 μM.

scholarly journals Restoration of the ATG5‑dependent autophagy sensitizes DU145 prostate cancer cells to chemotherapeutic drugs

2021 ◽  
Vol 22 (3) ◽  
Author(s):  
Ke Peng ◽  
Aiqin Sun ◽  
Jun Zhu ◽  
Jinyi Gao ◽  
Yanlin Li ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Chemotherapeutic Drugs ◽  
Prostate Cancer Cells
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