Dynamic Management Of A Delayed Delivery Vehicle In A City Logistics Environment

2008 ◽  
pp. 197-217 ◽  
Author(s):  
V. Zeimpekis ◽  
I. Minis ◽  
K. Mamassis ◽  
G.M. Giaglis
Keyword(s):  
City Logistics ◽  
Delivery Vehicle ◽  
Dynamic Management

Advancing the Therapeutic Efficacy of Bioactive Molecules by Delivery Vehicle Platforms.

2020 ◽  
Vol 27 ◽  
Author(s):  
Antonis D. Tsiailanis ◽  
Andreas G. Tzakos ◽  
Thomas Mavromoustakos
Keyword(s):  
Gold Nanoparticles ◽  
Angiotensin Ii ◽  
Therapeutic Index ◽  
Bioactive Molecules ◽  
Host Molecule ◽  
Delivery Vehicle ◽  
Metabolic Products ◽  
Activity Enhancement ◽  
Technological Platforms ◽  
Low Solubility

: Drugs have to overcome numerous barriers to reach their desired therapeutic targets. In several cases drugs, especially the highly lipophilic molecules, suffer from low solubility and bioavailability and therefore their desired targeting is hampered. In addition, undesired metabolic products might be produced or off-targets could be recognized. Along these lines, nanopharmacology has provided new technological platforms, to overcome these boundaries. Specifically, numerous vehicle platforms such as cyclodextrins and calixarenes have been widely utilized to host lipophilic drugs such as antagonists of the angiotensin II AT1 receptor (AT1R), as well as quercetin and silibinin. The encapsulation of these drugs in supramolecules or other systems refines their solubility and metabolic stability, increases their selectivity and therefore decreases their effective dose and improves the therapeutic index. In this minireview we report on the formulations of Silibinin and AT1R antagonist candesartan in a 2-HP-β-cyclodextrin host molecule, which displayed enhanced cytotoxicity and increased silibinin’s and candesartan’s stability, respectively. Moreover we describe the encapsulation of quercetin in gold nanoparticles bearing a calixarene supramolecular host. Also the encapsulation of temozolomide in a calixarene nanocapsule has been described. Finally, we report on the activity enhancement that has been achieved upon using these formulations as well as the analytical and computational methods we used to characterize these formulations and explore the molecular interactions between the host and quest molecules.

Exosomes: Structure, Biogenesis, Types and Application in Diagnosis and Gene and Drug Delivery

2020 ◽  
Vol 20 (3) ◽  
pp. 195-206 ◽  
Author(s):  
Shriya Agarwal ◽  
Vinayak Agarwal ◽  
Mugdha Agarwal ◽  
Manisha Singh
Keyword(s):  
Drug Delivery ◽  
Gene Therapy ◽  
Immune Responses ◽  
Biological Membrane ◽  
Gene Isolation ◽  
Delivery Vehicle ◽  
Scientific Communities ◽  
Therapeutic Regime ◽  
Targeted Gene Therapy ◽  
Delivery Mechanism

Abstract: In recent times, several approaches for targeted gene therapy (GT) had been studied. However, the emergence of extracellular vesicles (EVs) as a shuttle carrying genetic information between cells has gained a lot of interest in scientific communities. Owing to their higher capabilities in dealing with short sequences of nucleic acid (mRNA, miRNA), proteins, recombinant proteins, exosomes, the most popular form of EVs are viewed as reliable biological therapeutic conveyers. They have natural access through every biological membrane and can be employed for site-specific and efficient drug delivery without eliciting any immune responses hence, qualifying as an ideal delivery vehicle. Also, there are many research studies conducted in the last few decades on using exosome-mediated gene therapy into developing an effective therapy with the concept of a higher degree of precision in gene isolation, purification and delivery mechanism loading, delivery and targeting protocols. This review discusses several facets that contribute towards developing an efficient therapeutic regime for gene therapy, highlighting limitations and drawbacks associated with current GT and suggested therapeutic regimes.

Design and Build-up of an Electric Delivery Vehicle

ATZ worldwide ◽  
2014 ◽  
Vol 116 (9) ◽  
pp. 20-25
Author(s):  
Micha Lesemann ◽  
Thomas Welfers ◽  
Björn Mohrmann ◽  
Lutz Eckstein
Keyword(s):  
Delivery Vehicle

Mechanism of vocational education promoting precision poverty alleviation

2021 ◽  
pp. 002072092098350
Author(s):  
Chunqiu Xu ◽  
Yang Sun
Keyword(s):  
Education Reform ◽  
Vocational Education ◽  
Junior High School ◽  
Poverty Alleviation ◽  
Capita Income ◽  
Educational Background ◽  
Per Capita Income ◽  
Effective Mechanism ◽  
Dynamic Management ◽  
Per Capita

The purpose of this study is to study in depth the effective mechanism of China's vocational education reform to promote the poverty alleviation of precision industries. The purpose of this research is to deeply study the effective mechanism of my country's vocational education reform to promote precision industry poverty alleviation, and investigate the financial aid for poor students and the number of aids of a secondary vocational college for 5 consecutive years. Investigate the number of registered poor agricultural households in a city for five consecutive years, the number of rural labor transfers in employment, and the growth of per capita income of farmers. Taking 100 poor families in a poverty-stricken county as an example to investigate and analyze the educational background, knowledge level and attitudes of parents and students to school. Investigate various major local technical trainings conducted in a city for 5 consecutive years. The results show that the poverty subsidy of vocational schools has increased year by year, and the number of poverty subsidies has also increased. Among them, the intensity of targeted poverty alleviation has also been continuously strengthened. The dynamic management of information on the establishment of filing cards has greatly improved the precision of poverty alleviation and realized dynamic management. Per capita income has also achieved steady growth. At the same time, most parents have a junior high school diploma, and the student's academic qualifications are generally not high. In view of the attitude to school, most parents believe that it is very necessary, but the students think that they can not go up. There are more and more people participating in the main technical training in various localities, and more and more training projects are taking place, and the proportion is gradually increasing. These jobs are of great significance to the development of today's society.

Human amniotic membrane as a delivery vehicle for stem cell-based therapies

Life Sciences ◽  
2021 ◽  
pp. 119157
Author(s):  
Ping Chen ◽  
Minjun Lu ◽  
Tao Wang ◽  
Dongchun Dian ◽  
Yong Zhong ◽  
...  
Keyword(s):  
Stem Cell ◽  
Amniotic Membrane ◽  
Human Amniotic Membrane ◽  
Delivery Vehicle

Priority-based stakeholders analysis in the view of sustainable city logistics: Evidence for Tricity, Poland

2021 ◽  
Vol 67 ◽  
pp. 102751
Author(s):  
Jagienka Rześny-Cieplińska ◽  
Agnieszka Szmelter-Jarosz ◽  
Sarbast Moslem
Keyword(s):  
City Logistics ◽  
Sustainable City

Competing through the last mile: Strategic 3D printing in a city logistics context

2021 ◽  
Vol 131 ◽  
pp. 105248
Author(s):  
Emrah Demir ◽  
Daniel Eyers ◽  
Yuan Huang
Keyword(s):  
3D Printing ◽  
City Logistics ◽  
Last Mile
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