Bioluminescence Methodology for Ion Channel Studies

Patch Clamp Electrophysiology - Methods in Molecular Biology ◽

10.1007/978-1-0716-0818-0_10 ◽

2020 ◽

pp. 191-228

Author(s):

Paul A. Wadsworth ◽

Aditya K. Singh ◽

Nghi Nguyen ◽

Clifford Stephan ◽

Fernanda Laezza

Keyword(s):

Ion Channel

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Myrsinane and related diterpenes from Euphorbia falcata with selective potassium ion channel activity

Planta Medica ◽

10.1055/s-0035-1565539 ◽

2015 ◽

Vol 81 (16) ◽

Author(s):

A Vasas ◽

P Orvos ◽

L Tálosi ◽

P Forgo ◽

G Pinke ◽

...

Keyword(s):

Ion Channel ◽

Potassium Ion ◽

Channel Activity ◽

Potassium Ion Channel

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Ion channel alterations and epilepsy in mice and man

Neuropediatrics ◽

10.1055/s-2005-867952 ◽

2005 ◽

Vol 36 (02) ◽

Author(s):

CM Becker ◽

J Brill ◽

K Becker

Keyword(s):

Ion Channel

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Ion Channel Remodelling in Atrial Fibrillation

European Cardiology Review ◽

10.15420/ecr.2011.7.2.97 ◽

2011 ◽

Vol 7 (2) ◽

pp. 97 ◽

Cited By ~ 6

Author(s):

Niels Voigt ◽

Dobromir Dobrev ◽

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Keyword(s):

Atrial Fibrillation ◽

Ion Channel ◽

Antiarrhythmic Drugs ◽

Current Knowledge ◽

Bleeding Complications ◽

Large Size ◽

Cardiovascular Morbidity And Mortality ◽

Number Of Patients ◽

Life Threatening ◽

Underlying Mechanisms

Atrial fibrillation (AF) is the most common arrhythmia and is associated with substantial cardiovascular morbidity and mortality, with stroke being the most critical complication. Present drugs used for the therapy of AF (antiarrhythmics and anticoagulants) have major limitations, including incomplete efficacy, risks of life-threatening proarrhythmic events and bleeding complications. Non-pharmacological ablation procedures are efficient and apparently safe, but the very large size of the patient population allows ablation treatment of only a small number of patients. These limitations largely result from limited knowledge about the underlying mechanisms of AF and there is a hope that a better understanding of the molecular basis of AF may lead to the discovery of safer and more effective therapeutic targets. This article reviews the current knowledge about AF-related ion-channel remodelling and discusses how these alterations might affect the efficacy of antiarrhythmic drugs.

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