A Murine Incisional Fetal Wound-Healing Model to Study Scarless and Fibrotic Skin Repair

2020 ◽  
pp. 13-21
Author(s):  
Traci A. Wilgus
Keyword(s):  
Wound Healing ◽  
Fetal Wound Healing ◽  
Skin Repair ◽  
Wound Healing Model ◽  
Fetal Wound ◽  
Healing Model

scholarly journals Galvanic microparticles increase migration of human dermal fibroblasts in a wound-healing model via reactive oxygen species pathway

2014 ◽  
Vol 320 (1) ◽  
pp. 79-91 ◽  
Author(s):  
Nina Tandon ◽  
Elisa Cimetta ◽  
Aranzazu Villasante ◽  
Nicolette Kupferstein ◽  
Michael D. Southall ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Wound Healing ◽  
Reactive Oxygen ◽  
Dermal Fibroblasts ◽  
Oxygen Species ◽  
Human Dermal Fibroblasts ◽  
Wound Healing Model ◽  
Healing Model

scholarly journals Transcriptomic Analysis of a Diabetic Skin-Humanized Mouse Model Dissects Molecular Pathways Underlying the Delayed Wound Healing Response

Genes ◽  
2020 ◽  
Vol 12 (1) ◽  
pp. 47
Author(s):  
Carlos León ◽  
Francisco García-García ◽  
Sara Llames ◽  
Eva García-Pérez ◽  
Marta Carretero ◽  
...  
Keyword(s):  
Wound Healing ◽  
Functional Enrichment ◽  
Preclinical Model ◽  
Published Data ◽  
Diabetic Patients ◽  
Ulcer Formation ◽  
Histological Features ◽  
Depth Analysis ◽  
Wound Healing Model ◽  
Healing Model

Defective healing leading to cutaneous ulcer formation is one of the most feared complications of diabetes due to its consequences on patients’ quality of life and on the healthcare system. A more in-depth analysis of the underlying molecular pathophysiology is required to develop effective healing-promoting therapies for those patients. Major architectural and functional differences with human epidermis limit extrapolation of results coming from rodents and other small mammal-healing models. Therefore, the search for reliable humanized models has become mandatory. Previously, we developed a diabetes-induced delayed humanized wound healing model that faithfully recapitulated the major histological features of such skin repair-deficient condition. Herein, we present the results of a transcriptomic and functional enrichment analysis followed by a mechanistic analysis performed in such humanized wound healing model. The deregulation of genes implicated in functions such as angiogenesis, apoptosis, and inflammatory signaling processes were evidenced, confirming published data in diabetic patients that in fact might also underlie some of the histological features previously reported in the delayed skin-humanized healing model. Altogether, these molecular findings support the utility of such preclinical model as a valuable tool to gain insight into the molecular basis of the delayed diabetic healing with potential impact in the translational medicine field.

scholarly journals Studies in Fetal Wound Healing V. A Prolonged Presence of Hyaluronic Acid Characterizes Fetal Wound Fluid

1991 ◽  
Vol 213 (4) ◽  
pp. 292-296 ◽  
Author(s):  
MICHAEL T. LONGAKER ◽  
ERNIE S. CHIU ◽  
N. SCOTT ADZICK ◽  
MICHAEL STERN ◽  
MICHAEL R. HARRISON ◽  
...  
Keyword(s):  
Wound Healing ◽  
Hyaluronic Acid ◽  
Wound Fluid ◽  
Fetal Wound Healing ◽  
Fetal Wound

scholarly journals Morphological Evaluation of Wound Healing Events in the Excisional Wound Healing Model in Rats

BIO-PROTOCOL ◽  
2019 ◽  
Vol 9 (13) ◽  
Author(s):  
Ligia Estevão ◽  
Puebla Cassini-Vieira ◽  
Ana Greice Leite ◽  
Apolônia Bulhões ◽  
Lucíola da Barcelos ◽  
...  
Keyword(s):  
Wound Healing ◽  
Morphological Evaluation ◽  
Excisional Wound ◽  
Wound Healing Model ◽  
Healing Model

Sanativo Wound Healing Product Does Not Accelerate Reepithelialization in a Mouse Cutaneous Wound Healing Model

2017 ◽  
Vol 139 (2) ◽  
pp. 343-352 ◽  
Author(s):  
Clement D. Marshall ◽  
Michael S. Hu ◽  
Tripp Leavitt ◽  
Leandra A. Barnes ◽  
Alexander T. M. Cheung ◽  
...  
Keyword(s):  
Wound Healing ◽  
Cutaneous Wound Healing ◽  
Cutaneous Wound ◽  
Wound Healing Model ◽  
Healing Model

A Tissue-Engineered Corneal Wound Healing Model for the Characterization of Reepithelialization

2013 ◽  
pp. 59-78 ◽  
Author(s):  
Karine Zaniolo ◽  
Patrick Carrier ◽  
Sylvain L. Guérin ◽  
François A. Auger ◽  
Lucie Germain
Keyword(s):  
Wound Healing ◽  
Corneal Wound Healing ◽  
Corneal Wound ◽  
Wound Healing Model ◽  
Healing Model
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