Evaluations of Environmental Pollutant-Induced Mitochondrial Toxicity Using Caenorhabditis elegans as a Model System

2021 ◽  
pp. 33-46
Author(s):  
Fuli Zheng ◽  
Michael Aschner ◽  
Huangyuan Li
Keyword(s):  
Caenorhabditis Elegans ◽  
Environmental Pollutant ◽  
Model System ◽  
Mitochondrial Toxicity

scholarly journals Caenorhabditis elegans as a Model System for Studying Drug Induced Mitochondrial Toxicity

PLoS ONE ◽  
2015 ◽  
Vol 10 (5) ◽  
pp. e0126220 ◽  
Author(s):  
Richard de Boer ◽  
Ruben L. Smith ◽  
Winnok H. De Vos ◽  
Erik M. M. Manders ◽  
Stanley Brul ◽  
...  
Keyword(s):  
Caenorhabditis Elegans ◽  
Model System ◽  
Mitochondrial Toxicity ◽  
Drug Induced

scholarly journals Using Caenorhabditis elegans as a Model System to Study Protein Homeostasis in a Multicellular Organism

10.3791/50840 ◽  
2013 ◽  
Author(s):  
Ido Karady ◽  
Anna Frumkin ◽  
Shiran Dror ◽  
Netta Shemesh ◽  
Nadav Shai ◽  
...  
Keyword(s):  
Caenorhabditis Elegans ◽  
Model System ◽  
Multicellular Organism ◽  
Protein Homeostasis

Caenorhabditis elegans as a model system for target identification and drug screening against neurodegenerative diseases

2018 ◽  
Vol 819 ◽  
pp. 169-180 ◽  
Author(s):  
Liang Ma ◽  
Yudan Zhao ◽  
Yuchen Chen ◽  
Biao Cheng ◽  
Anlin Peng ◽  
...  
Keyword(s):  
Caenorhabditis Elegans ◽  
Neurodegenerative Diseases ◽  
Drug Screening ◽  
Target Identification ◽  
Model System

Genetic kidney diseases: Caenorhabditis elegans as model system

2017 ◽  
Vol 369 (1) ◽  
pp. 105-118 ◽  
Author(s):  
Athina Ganner ◽  
Elke Neumann-Haefelin
Keyword(s):  
Caenorhabditis Elegans ◽  
Kidney Diseases ◽  
Model System

Use of Caenorhabditis elegans as a non-mammalian model system to study Candida virulence

2015 ◽  
Vol 36 (2) ◽  
pp. 98
Author(s):  
Farkad Bantun ◽  
Sanjiveeni Dhamgaye ◽  
Anton Y Peleg
Keyword(s):  
Caenorhabditis Elegans ◽  
Model System

scholarly journals Caenorhabditis elegans as a Model System To Assess Candida glabrata, Candida nivariensis, and Candida bracarensis Virulence and Antifungal Efficacy

2020 ◽  
Vol 64 (10) ◽  
Author(s):  
Ainara Hernando-Ortiz ◽  
Estibaliz Mateo ◽  
Marcelo Ortega-Riveros ◽  
Iker De-la-Pinta ◽  
Guillermo Quindós ◽  
...  
Keyword(s):  
Caenorhabditis Elegans ◽  
Candida Glabrata ◽  
Model System ◽  
Antifungal Drugs ◽  
Phenotypic Traits ◽  
Content Type ◽  
C Elegans ◽  
Host Fungus ◽  
Candida Bracarensis ◽  
Candida Nivariensis

ABSTRACT Although Candida albicans remains the major etiological agent of invasive candidiasis, Candida glabrata and other emerging species of Candida are increasingly isolated. This species is the second most prevalent cause of candidiasis in many regions of the world. However, clinical isolates of Candida nivariensis and Candida bracarensis can be misidentified and are underdiagnosed due to phenotypic traits shared with C. glabrata. Little is known about the two cryptic species. Therefore, pathogenesis studies are needed to understand their virulence traits and their susceptibility to antifungal drugs. The susceptibility of Caenorhabditis elegans to different Candida species makes this nematode an excellent model for assessing host-fungus interactions. We evaluated the usefulness of C. elegans as a nonconventional host model to analyze the virulence of C. glabrata, C. nivariensis, and C. bracarensis. The three species caused candidiasis, and the highest virulence of C. glabrata was confirmed. Furthermore, we determined the efficacy of current antifungal drugs against the infection caused by these species in the C. elegans model. Amphotericin B and azoles showed the highest activity against C. glabrata and C. bracarensis infections, while echinocandins were more active for treating those caused by C. nivariensis. C. elegans proved to be a useful model system for assessing the pathogenicity of these closely related species.

scholarly journals Electrophysiological Measures of Aging Pharynx Function in C. elegans Reveal Enhanced Organ Functionality in Older, Long-lived Mutants

2017 ◽  
Vol 74 (8) ◽  
pp. 1173-1179 ◽  
Author(s):  
Joshua Coulter Russell ◽  
Nikolay Burnaevskiy ◽  
Bridget Ma ◽  
Miguel Arenas Mailig ◽  
Franklin Faust ◽  
...  
Keyword(s):  
Caenorhabditis Elegans ◽  
Heat Shock ◽  
Life Span ◽  
Insulin Signaling ◽  
Model System ◽  
Wild Type ◽  
Organ Function ◽  
C Elegans ◽  
Age Related ◽  
The Relationship

Abstract The function of the pharynx, an organ in the model system Caenorhabditis elegans, has been correlated with life span and motility (another measure of health) since 1980. In this study, in order to further understand the relationship between organ function and life span, we measured the age-related decline of the pharynx using an electrophysiological approach. We measured and analyzed electropharyngeograms (EPG) of wild type animals, short-lived hsf-1 mutants, and long-lived animals with genetically decreased insulin signaling or increased heat shock pathway signaling; we recorded a total of 2,478 EPGs from 1,374 individuals. As expected, the long-lived daf-2(e1370) and hsf-1OE(uthIs235) animals maintained pharynx function relatively closer to the youthful state during aging, whereas the hsf-1(sy441) and wild type animals’ pharynx function deviated significantly further from the youthful state at advanced age. Measures of the amount of variation in organ function can act as biomarkers of youthful physiology as well. Intriguingly, the long-lived animals had greater variation in the duration of pharynx contraction at older ages.

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