MicroRNA Expression Influences Methylmercury-Induced Lipid Accumulation and Mitochondrial Toxicity in Caenorhabditis elegans

2021 ◽  
Author(s):  
Tyson Nielsen ◽  
Nicole Crawford ◽  
Megan Martell ◽  
Belal Khalil ◽  
Farooq Imtiaz ◽  
...  
Keyword(s):  
Caenorhabditis Elegans ◽  
Lipid Accumulation ◽  
Microrna Expression ◽  
Mitochondrial Toxicity

scholarly journals Salvia hispanica L. (chia) seeds oil extracts reduce lipid accumulation and produce stress resistance in Caenorhabditis elegans

2018 ◽  
Vol 15 (1) ◽  
Author(s):  
Cristiane Freitas Rodrigues ◽  
Willian Salgueiro ◽  
Matheus Bianchini ◽  
Juliana Cristina Veit ◽  
Robson Luiz Puntel ◽  
...  
Keyword(s):  
Caenorhabditis Elegans ◽  
Stress Resistance ◽  
Lipid Accumulation ◽  
Salvia Hispanica ◽  
Salvia Hispanica L

Modulated microRNA expression during adult lifespan in Caenorhabditis elegans

Aging Cell ◽  
2006 ◽  
Vol 5 (3) ◽  
pp. 235-246 ◽  
Author(s):  
Carolina Ibanez-Ventoso ◽  
Maocheng Yang ◽  
Suzhen Guo ◽  
Harlan Robins ◽  
Richard W. Padgett ◽  
...  
Keyword(s):  
Caenorhabditis Elegans ◽  
Microrna Expression ◽  
Adult Lifespan

Antioxidant and reducing lipid accumulation effects of rutin in Caenorhabditis elegans

BioFactors ◽  
2021 ◽  
Author(s):  
Xianjin Qin ◽  
Wenqian Wang ◽  
Weihua Chu
Keyword(s):  
Caenorhabditis Elegans ◽  
Lipid Accumulation

scholarly journals Caenorhabditis elegans as a Model System for Studying Drug Induced Mitochondrial Toxicity

PLoS ONE ◽  
2015 ◽  
Vol 10 (5) ◽  
pp. e0126220 ◽  
Author(s):  
Richard de Boer ◽  
Ruben L. Smith ◽  
Winnok H. De Vos ◽  
Erik M. M. Manders ◽  
Stanley Brul ◽  
...  
Keyword(s):  
Caenorhabditis Elegans ◽  
Model System ◽  
Mitochondrial Toxicity ◽  
Drug Induced

scholarly journals Coal combustion related fine particulate matter (PM2.5) induces toxicity in Caenorhabditis elegans by dysregulating microRNA expression

2017 ◽  
Vol 6 (4) ◽  
pp. 432-441 ◽  
Author(s):  
Qiuli Wu ◽  
Xiaoxiao Han ◽  
Di Wang ◽  
Fang Zhao ◽  
Dayong Wang
Keyword(s):  
Particulate Matter ◽  
Caenorhabditis Elegans ◽  
Coal Combustion ◽  
Fine Particulate Matter ◽  
Microrna Expression ◽  
Assay System ◽  
Fine Particulate

We employed an in vivo assay system of Caenorhabditis elegans to determine if and which microRNAs (miRNAs) were dysregulated upon exposure to coal combustion related fine particulate matter (PM2.5) by profiling the miRNAs using SOLiD sequencing.

scholarly journals Autophagy-dependent gut-to-yolk biomass conversion generates visceral polymorbidity in aging C. elegans

2017 ◽  
Author(s):  
Marina Ezcurra ◽  
Alexandre Benedetto ◽  
Thanet Sornda ◽  
Ann F. Gilliat ◽  
Catherine Au ◽  
...  
Keyword(s):  
Caenorhabditis Elegans ◽  
Lipid Accumulation ◽  
Damage Accumulation ◽  
Biomass Conversion ◽  
Late Life ◽  
Unknown Etiology ◽  
Wild Type ◽  
Type Function ◽  
C Elegans ◽  
Theory Of Aging

Aging (senescence) is characterized by the development of numerous pathologies, some of which limit lifespan. Key to understanding aging is discovery of the mechanisms (etiologies) that cause senescent pathology. In Caenorhabditis elegans a major senescent pathology of unknown etiology is atrophy of its principal metabolic organ, the intestine. Here we identify a cause of not only this pathology, but also of yolky lipid accumulation and redistribution (a form of senescent obesity): autophagy-mediated conversion of intestinal biomass into yolk. Inhibiting intestinal autophagy or vitellogenesis rescues both visceral pathologies, and can also extend lifespan. This defines a disease syndrome leading to polymorbidity and contributing to late-life mortality. Activation of gut-to-yolk biomass conversion by insulin/IGF-1 signaling (IIS) promotes reproduction and senescence. This illustrates how major, IIS-promoted senescent pathologies in C. elegans can originate not from damage accumulation, but from continued action of a wild-type function (vitellogenesis), consistent with the recently proposed hyperfunction theory of aging.

scholarly journals NHR-80 senses the mitochondrial UPR to rewire citrate metabolism for lipid accumulation in Caenorhabditis elegans

Cell Reports ◽  
2022 ◽  
Vol 38 (2) ◽  
pp. 110206
Author(s):  
Rendan Yang ◽  
Yamei Li ◽  
Yanli Wang ◽  
Jingjing Zhang ◽  
Qijing Fan ◽  
...  
Keyword(s):  
Caenorhabditis Elegans ◽  
Lipid Accumulation ◽  
Citrate Metabolism
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