More than a Gender Issue: Testis as a Distinctive HIV Reservoir and Its Implication for Viral Eradication

Author(s):  
Jean-Pierre Routy ◽  
Franck P. Dupuy ◽  
John Lin ◽  
Stéphane Isnard
2021 ◽  
Vol 27 (1) ◽  
Author(s):  
Katia Romero Felizardo ◽  
Amanda Möhring Ramos ◽  
Claudia de O. Melo ◽  
Érica Ferreira de Souza ◽  
Nandamudi L. Vijaykumar ◽  
...  

Abstract Context While the digital economy requires a new generation of technology for scientists and practitioners, the software engineering (SE) field faces a gender crisis. SE research is a global enterprise that requires the participation of both genders for the advancement of science and evidence-based practice. However, women across the world tend to be significantly underrepresented in such research, receiving less funding and less participation, frequently, than men as authors in research publications. Data about this phenomenon is still sparse and incomplete; particularly in evidence-based software engineering (EBSE), there are no studies that analyze the participation of women in this research area. Objective The objective of this work is to present the results of a systematic mapping study (SM) conducted to collect and evaluate evidence on female researchers who have contributed to the area of EBSE. Method Our SM was performed by manually searching studies in the major conferences and journals of EBSE. We identified 981 studies and 183 were authored/co-authored by women and, therefore, included. Results Contributions from women in secondary studies have globally increased over the years, but it is still concentrated in European countries. Additionally, collaboration among research groups is still fragile, based on a few women as a bridge. Latin American researchers contribute a great deal to the field, despite they do not collaborate as much within their region. Conclusions The findings from this study are expected to be aggregated to the existing knowledge with respect to women’s contribution to the EBSE area. We expect that our results bring up a reflection on the gender issue and motivate actions and policies to attract female researchers to this area.


Author(s):  
Véronique Avettand-Fenoel ◽  
Jérôme Lechenadec ◽  
Mariama Sadjo Diallo ◽  
Marine Fillion ◽  
Adeline Melard ◽  
...  

Abstract Background Early combined antiretroviral therapy (cART) limits the total HIV-DNA load in children. However, data on its impact in older children and adolescents remain scarce. This study aims to compare HIV reservoirs in children (5-12 years) and adolescents (13-17 years) who started cART before 6 months (early (E-)group) or after 2 years old (late (L-)group). Methods The ANRS-EP59-CLEAC study prospectively enrolled 76 HIV-1 perinatally-infected patients who reached HIV-RNA<400 copies/mL less than 24 months after cART initiation, regardless of subsequent viral suppression (E-group: 27 children, 9 adolescents; L-group: 19 children, 21 adolescents). Total and integrated HIV-DNA were quantified in blood and in CD4+ T cell subsets. A substudy assessed HIV reservoir inducibility after ex vivo peripheral blood mononuclear cells (PBMCs) stimulation. Results Total HIV-DNA levels were lower in early- than late-treated patients (Children: 2.14 vs 2.87 log cp/million PBMCs, p<0.0001; Adolescents: 2.25 vs 2.74log, p<0.0001). Low reservoir was independently associated with treatment precocity, protective HLA and low cumulative viremia since cART initiation. The 60 participants with undetectable integrated HIV-DNA started cART earlier than the other patients (4 vs 54 months, p=0.03). In those with sustained virological control, transitional memory and effector memory CD4+T cells were less infected in the E-group than in the L-group (p=0.03 and 0.02, respectively). Viral inducibility of reservoir cells after normalization to HIV-DNA levels was similar between the groups. Conclusions Early cART results in a smaller blood HIV reservoir until adolescence, but all tested participants had an inducible reservoir. This deserves cautious consideration for HIV remission strategies.


HIV Medicine ◽  
2017 ◽  
Vol 18 (10) ◽  
pp. 777-781 ◽  
Author(s):  
J Tiraboschi ◽  
S Ray ◽  
K Patel ◽  
A Teague ◽  
M Pace ◽  
...  

2008 ◽  
Vol 43 (1) ◽  
pp. 45-64 ◽  
Author(s):  
Anne Marie Kavanagh ◽  
Rebecca Bentley
Keyword(s):  

2017 ◽  
Vol 31 (5) ◽  
pp. 785-786 ◽  
Author(s):  
Maria Ida Maiorino ◽  
Giuseppe Bellastella ◽  
Katherine Esposito

Immunity ◽  
2012 ◽  
Vol 36 (3) ◽  
pp. 320-321 ◽  
Author(s):  
Stephen A. Migueles ◽  
Mark Connors

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