The Role of Heat Shock Proteins in the Elicitation of Immune Responses

2007 ◽  
pp. 173-187
Author(s):  
Charles A Gullo ◽  
Paul Macary ◽  
Michael Graner
Keyword(s):  
Heat Shock ◽  
Heat Shock Proteins ◽  
Immune Responses ◽  
Shock Proteins

Physiological Functions of Heat Shock Proteins

2020 ◽  
Vol 21 (8) ◽  
pp. 751-760 ◽  
Author(s):  
Qiang Shan ◽  
Fengtao Ma ◽  
Jingya Wei ◽  
Hongyang Li ◽  
Hui Ma ◽  
...  
Keyword(s):  
Heart Disease ◽  
Heat Stress ◽  
Heat Shock ◽  
Cancer Therapy ◽  
Heat Shock Proteins ◽  
Immune Responses ◽  
Molecular Chaperones ◽  
General Medicine ◽  
Shock Proteins

Heat shock proteins (HSPs) are molecular chaperones involved in a variety of life activities. HSPs function in the refolding of misfolded proteins, thereby contributing to the maintenance of cellular homeostasis. Heat shock factor (HSF) is activated in response to environmental stresses and binds to heat shock elements (HSEs), promoting HSP translation and thus the production of high levels of HSPs to prevent damage to the organism. Here, we summarize the role of molecular chaperones as anti-heat stress molecules and their involvement in immune responses and the modulation of apoptosis. In addition, we review the potential application of HSPs to cancer therapy, general medicine, and the treatment of heart disease.

scholarly journals The Pathophysiological Role of Heat Shock Response in Autoimmunity: A Literature Review

Cells ◽  
2021 ◽  
Vol 10 (10) ◽  
pp. 2626
Author(s):  
Ariadni Androvitsanea ◽  
Kostas Stylianou ◽  
Eleni Drosataki ◽  
Ioannis Petrakis
Keyword(s):  
Immune System ◽  
Heat Shock ◽  
Literature Review ◽  
Heat Shock Proteins ◽  
Immune Responses ◽  
Inhibitory Effects ◽  
Pathophysiological Role ◽  
Shock Response ◽  
Shock Proteins

Within the last two decades, there has been increasing evidence that heat-shock proteins can have a differential influence on the immune system. They can either provoke or ameliorate immune responses. This review focuses on outlining the stimulatory as well as the inhibitory effects of heat-shock proteins 27, 40, 70, 65, 60, and 90 in experimental and clinical autoimmune settings.

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