Physiological Functions of Heat Shock Proteins

2020 ◽  
Vol 21 (8) ◽  
pp. 751-760 ◽  
Author(s):  
Qiang Shan ◽  
Fengtao Ma ◽  
Jingya Wei ◽  
Hongyang Li ◽  
Hui Ma ◽  
...  
Keyword(s):  
Heart Disease ◽  
Heat Stress ◽  
Heat Shock ◽  
Cancer Therapy ◽  
Heat Shock Proteins ◽  
Immune Responses ◽  
Molecular Chaperones ◽  
General Medicine ◽  
Shock Proteins

Heat shock proteins (HSPs) are molecular chaperones involved in a variety of life activities. HSPs function in the refolding of misfolded proteins, thereby contributing to the maintenance of cellular homeostasis. Heat shock factor (HSF) is activated in response to environmental stresses and binds to heat shock elements (HSEs), promoting HSP translation and thus the production of high levels of HSPs to prevent damage to the organism. Here, we summarize the role of molecular chaperones as anti-heat stress molecules and their involvement in immune responses and the modulation of apoptosis. In addition, we review the potential application of HSPs to cancer therapy, general medicine, and the treatment of heart disease.

scholarly journals Heat Shock Proteins in Alzheimer’s Disease: Role and Targeting

2018 ◽  
Vol 19 (9) ◽  
pp. 2603 ◽  
Author(s):  
Claudia Campanella ◽  
Andrea Pace ◽  
Celeste Caruso Bavisotto ◽  
Paola Marzullo ◽  
Antonella Marino Gammazza ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Heat Shock ◽  
Heat Shock Proteins ◽  
Molecular Chaperones ◽  
Protein Misfolding ◽  
Point Of View ◽  
Toxic Species ◽  
Shock Proteins

Among diseases whose cure is still far from being discovered, Alzheimer’s disease (AD) has been recognized as a crucial medical and social problem. A major issue in AD research is represented by the complexity of involved biochemical pathways, including the nature of protein misfolding, which results in the production of toxic species. Considering the involvement of (mis)folding processes in AD aetiology, targeting molecular chaperones represents a promising therapeutic perspective. This review analyses the connection between AD and molecular chaperones, with particular attention toward the most important heat shock proteins (HSPs) as representative components of the human chaperome: Hsp60, Hsp70 and Hsp90. The role of these proteins in AD is highlighted from a biological point of view. Pharmacological targeting of such HSPs with inhibitors or regulators is also discussed.

scholarly journals Heat shock protein (HSP) release mechanism under heat stress pressure in Goats: a review

2022 ◽  
Vol 335 ◽  
pp. 00046
Author(s):  
Rafika Febriani Putri ◽  
Tri Eko Susilorini ◽  
Nashi Widodo ◽  
Kuswati Kuswati ◽  
Suyadi Suyadi
Keyword(s):  
Heat Stress ◽  
Heat Shock ◽  
Heat Shock Proteins ◽  
Scientific Evidence ◽  
Animal Health ◽  
Stressful Events ◽  
Release Mechanism ◽  
Stress Markers ◽  
Shock Proteins

Among the various climate variables, heat stress has been reported to be the most detrimental factor to the economy of the livestock industry. Heat stress is one of the most stressful events in the life of livestock with harmful consequences for animal health, productivity and product quality. Heat shock proteins (HSPs), also known as molecular chaperons, are prominent stress markers. Heat shock proteins consist of highly conserved protein expressed at the time of stress, and play an important role in adaptation to the environmental stress. This review discusses the scientific evidence regarding the effects of heat stress and role of HSP during heat stress on Goats.

Heat stress modulated gastrointestinal barrier dysfunction: role of tight junctions and heat shock proteins

2017 ◽  
Vol 52 (12) ◽  
pp. 1315-1319 ◽  
Author(s):  
Avinash Gupta ◽  
Nishant Ranjan Chauhan ◽  
Daipayan Chowdhury ◽  
Ajeet Singh ◽  
Ramesh Chand Meena ◽  
...  
Keyword(s):  
Heat Stress ◽  
Heat Shock ◽  
Heat Shock Proteins ◽  
Tight Junctions ◽  
Barrier Dysfunction ◽  
Gastrointestinal Barrier ◽  
Shock Proteins

scholarly journals Role of Heat Shock Proteins in Improving Heat Stress Tolerance in Crop Plants

2016 ◽  
pp. 283-307 ◽  
Author(s):  
Palakolanu Sudhakar Reddy ◽  
Thammineni Chakradhar ◽  
Ramesha A. Reddy ◽  
Rahul B. Nitnavare ◽  
Srikrishna Mahanty ◽  
...  
Keyword(s):  
Heat Stress ◽  
Heat Shock ◽  
Heat Shock Proteins ◽  
Stress Tolerance ◽  
Crop Plants ◽  
Heat Stress Tolerance ◽  
Shock Proteins
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