KSHV (Kaposi sarcoma associated herpes virus)

2008 ◽  
pp. 1068-1068
Keyword(s):  
Herpes Virus ◽  
Kaposi Sarcoma ◽  
Herpès Virus

scholarly journals Primary effusion lymphoma occurring in the setting of transplanted patients: a systematic review of a rare, life-threatening post-transplantation occurrence

BMC Cancer ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Magda Zanelli ◽  
Francesca Sanguedolce ◽  
Maurizio Zizzo ◽  
Andrea Palicelli ◽  
Maria Chiara Bassi ◽  
...  
Keyword(s):  
Systematic Review ◽  
Herpes Virus ◽  
Primary Effusion Lymphoma ◽  
Kaposi Sarcoma ◽  
Body Cavity ◽  
Solid Organ ◽  
Human Herpes Virus 8 ◽  
Post Transplant ◽  
Human Herpes Virus ◽  
Herpès Virus

Abstract Background Primary effusion lymphoma is a rare, aggressive large B-cell lymphoma strictly linked to infection by Human Herpes virus 8/Kaposi sarcoma-associated herpes virus. In its classic form, it is characterized by body cavities neoplastic effusions without detectable tumor masses. It often occurs in immunocompromised patients, such as HIV-positive individuals. Primary effusion lymphoma may affect HIV-negative elderly patients from Human Herpes virus 8 endemic regions. So far, rare cases have been reported in transplanted patients. The purpose of our systematic review is to improve our understanding of this type of aggressive lymphoma in the setting of transplantation, focusing on epidemiology, clinical presentation, pathological features, differential diagnosis, treatment and outcome. The role of assessing the viral serological status in donors and recipients is also discussed. Methods We performed a systematic review adhering to the PRISMA guidelines. The literature search was conducted on PubMed/MEDLINE, Web of Science, Scopus, EMBASE and Cochrane Library, using the search terms “primary effusion lymphoma” and “post-transplant”. Results Our search identified 13 cases of post-transplant primary effusion lymphoma, predominantly in solid organ transplant recipients (6 kidney, 3 heart, 2 liver and 1 intestine), with only one case after allogenic bone marrow transplantation. Long-term immunosuppression is important in post-transplant primary effusion lymphoma commonly developing several years after transplantation. Kaposi Sarcoma occurred in association with lymphoma in 4 cases of solid organ recipients. The lymphoma showed the classical presentation with body cavity effusions in absence of tumor masses in 10 cases; 2 cases presented as solid masses, lacking effusions and one case as effusions associated with multiple organ involvement. Primary effusion lymphoma occurring in the setting of transplantation was more often Epstein Barr-virus negative. The prognosis was poor. In addition to chemotherapy, reduction of immunosuppressive treatment, was generally attempted. Conclusions Primary effusion lymphoma is a rare, but often fatal post-transplant complication. Its rarity and the difficulty in achieving the diagnosis may lead to miss this complication. Clinicians should suspect primary effusion lymphoma in transplanted patients, presenting generally with unexplained body cavity effusions, although rare cases with solid masses are described.

Herpes virus (KSHV) associated kaposi sarcoma in a 3-year-old child with non-HIV-induced immunodeficiency

1997 ◽  
Vol 156 (6) ◽  
pp. 440-443 ◽  
Author(s):  
G. Kusenbach ◽  
A. Rübben ◽  
E. M. Schneider ◽  
M. Barker ◽  
A. Büssing ◽  
...  
Keyword(s):  
Herpes Virus ◽  
Kaposi Sarcoma ◽  
Herpès Virus

scholarly journals ComplexN-Linked Glycans on Asn-89 of Kaposi Sarcoma Herpes Virus-encoded Interleukin-6 Mediate Optimal Function by Affecting Cytokine Protein Conformation

2009 ◽  
Vol 284 (43) ◽  
pp. 29269-29282 ◽  
Author(s):  
Charles S. Dela Cruz ◽  
Srinivas R. Viswanathan ◽  
Ayman S. El-Guindy ◽  
Duane Shedd ◽  
George Miller
Keyword(s):  
Interleukin 6 ◽  
Protein Conformation ◽  
Herpes Virus ◽  
Kaposi Sarcoma ◽  
Optimal Function ◽  
Kaposi Sarcoma Herpes Virus ◽  
Herpès Virus

scholarly journals HHV8-Negative Primary Effusion Lymphoma of B-Cell Lineage: Two Cases and a Comprehensive Review of the Literature

2013 ◽  
Vol 2013 ◽  
pp. 1-12 ◽  
Author(s):  
Neeraj Saini ◽  
Ephraim P. Hochberg ◽  
Erica A. Linden ◽  
Smita Jha ◽  
Heinz K. Grohs ◽  
...  
Keyword(s):  
B Cell ◽  
English Language ◽  
Herpes Virus ◽  
Primary Effusion Lymphoma ◽  
Cell Lineage ◽  
Kaposi Sarcoma ◽  
Body Cavity ◽  
Lymphoid Cells ◽  
Human Herpes Virus 8 ◽  
Herpès Virus

Primary effusion lymphoma (PEL) is a rare extranodal lymphoma that typically presents in a body cavity in the absence of a detectable tumor mass and that occurs predominantly in immunosuppressed individuals. The neoplastic lymphoid cells are frequently infected with human herpes virus 8 (HHV8), also known as Kaposi sarcoma herpes virus (KSHV). We describe two HIV-negative patients who presented with primary effusion lymphoma of B-cell lineage involving the pleural cavity, but whose tumor cells lacked infection by HHV8. We review the English language literature of HHV8-negative PEL of B-cell lineage and compare these lymphomas to HHV8-associated PEL with regard to clinical and pathological characteristics, therapy, and outcome.

In cis inhibition of antigen processing by the latency-associated nuclear antigen I of Kaposi sarcoma Herpes virus

2007 ◽  
Vol 44 (6) ◽  
pp. 1352-1360 ◽  
Author(s):  
Arnaud Zaldumbide ◽  
Martine Ossevoort ◽  
Emmanuel J.H.J. Wiertz ◽  
Rob C. Hoeben
Keyword(s):  
Antigen Processing ◽  
Herpes Virus ◽  
Kaposi Sarcoma ◽  
Nuclear Antigen ◽  
Kaposi Sarcoma Herpes Virus ◽  
Herpès Virus ◽  
In Cis

NFκB pathway is down-regulated by 1α,25(OH)2-vitamin D3 in endothelial cells transformed by Kaposi sarcoma-associated herpes virus G protein coupled receptor

Steroids ◽  
2012 ◽  
Vol 77 (11) ◽  
pp. 1025-1032 ◽  
Author(s):  
Verónica Gonzalez-Pardo ◽  
Noelia D’Elia ◽  
Annemieke Verstuyf ◽  
Ricardo Boland ◽  
Ana Russo de Boland
Keyword(s):  
Endothelial Cells ◽  
G Protein ◽  
Vitamin D3 ◽  
Herpes Virus ◽  
Kaposi Sarcoma ◽  
G Protein Coupled Receptor ◽  
Herpès Virus ◽  
Nfκb Pathway ◽  
G Protein Coupled

scholarly journals Lymphatic Reprogramming by Kaposi Sarcoma Herpes Virus Promotes the Oncogenic Activity of the Virus-Encoded G-protein–Coupled Receptor

2012 ◽  
Vol 72 (22) ◽  
pp. 5833-5842 ◽  
Author(s):  
Berenice Aguilar ◽  
Inho Choi ◽  
Dongwon Choi ◽  
Hee Kyoung Chung ◽  
Sunju Lee ◽  
...  
Keyword(s):  
G Protein ◽  
Herpes Virus ◽  
Kaposi Sarcoma ◽  
G Protein Coupled Receptor ◽  
Oncogenic Activity ◽  
Kaposi Sarcoma Herpes Virus ◽  
Herpès Virus ◽  
G Protein Coupled
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