Clioquinol Protects Against Cell Death in Parkinson’s Disease Models In Vivo and In Vitro

2009 ◽  
pp. 431-442 ◽  
Author(s):  
Simon Wilkins ◽  
Colin L. Masters ◽  
Ashley I. Bush ◽  
Robert A. Cherny ◽  
David I. Finkelstein
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cell Death ◽  
Disease Models

3.235 ISOTHIOCYANATES PROTECT AGAINST DOPAMINERGIC CELL DEATH IN IN VITRO AND IN VIVO MODELS OF PARKINSON'S DISEASE

2012 ◽  
Vol 18 ◽  
pp. S212
Author(s):  
F. Morroni ◽  
P. Hrelia ◽  
C. Bolondi ◽  
G. Cantelli-Forti ◽  
A. Tarozzi
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cell Death ◽  
In Vivo Models ◽  
Dopaminergic Cell

scholarly journals Ablation of RIP3 protects from dopaminergic neurodegeneration in experimental Parkinson’s disease

2019 ◽  
Vol 10 (11) ◽  
Author(s):  
Pedro A. Dionísio ◽  
Sara R. Oliveira ◽  
Maria M. Gaspar ◽  
Maria J. Gama ◽  
Margarida Castro-Caldas ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cell Death ◽  
Cultured Cells ◽  
Substantia Nigra Pars Compacta ◽  
Neuronal Cultures ◽  
Interacting Protein ◽  
Dopaminergic Neurodegeneration

Abstract Parkinson’s disease (PD) is driven by dopaminergic neurodegeneration in the substantia nigra pars compacta (SN) and striatum. Although apoptosis is considered the main neurodegenerative mechanism, other cell death pathways may be involved. In this regard, necroptosis is a regulated form of cell death dependent on receptor interacting protein 3 (RIP3), a protein also implicated in apoptosis and inflammation independently of its pro-necroptotic activity. Here, we explored the role of RIP3 genetic deletion in in vivo and in vitro PD models. Firstly, wild-type (Wt) and RIP3 knockout (RIP3ko) mice were injected intraperitoneally with MPTP (40 mg/kg, i.p.), and sacrificed after either 6 or 30 days. RIP3ko protected from dopaminergic neurodegeneration in the SN of MPTP-injected mice, but this effect was independent of necroptosis. In keeping with this, necrostatin-1s (10 mg/kg/day, i.p.) did not afford full neuroprotection. Moreover, MPTP led to DNA fragmentation, caspase-3 activation, lipid peroxidation and BAX expression in Wt mice, in the absence of caspase-8 cleavage, suggesting intrinsic apoptosis. This was mimicked in primary cortical neuronal cultures exposed to the active MPTP metabolite. RIP3 deficiency in cultured cells and in mouse brain abrogated all phenotypes. Curiously, astrogliosis was increased in the striatum of MPTP-injected Wt mice and further exacerbated in RIP3ko mice. This was accompanied by absence of microgliosis and reposition of glial cell line-derived neurotrophic factor (GDNF) levels in the striata of MPTP-injected RIP3ko mice when compared to MPTP-injected Wt mice, which in turn showed a massive GDNF decrease. RIP3ko primary mixed glial cultures also presented decreased expression of inflammation-related genes upon inflammatory stimulation. These findings hint at possible undescribed non-necroptotic roles for RIP3 in inflammation and MPTP-driven cell death, which can contribute to PD progression.

scholarly journals Achyranthes bidentata polypeptide protects dopaminergic neurons from apoptosis in Parkinson's disease models both in vitro and in vivo

2018 ◽  
Vol 175 (4) ◽  
pp. 631-643 ◽  
Author(s):  
Su Peng ◽  
Caiping Wang ◽  
Jinyu Ma ◽  
Ketao Jiang ◽  
Yuhui Jiang ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Dopaminergic Neurons ◽  
Disease Models ◽  
Achyranthes Bidentata

scholarly journals Effects of the probiotic formulation SLAB51 in in vitro and in vivo Parkinson’s disease models

Aging ◽  
2020 ◽  
Vol 12 (5) ◽  
pp. 4641-4659 ◽  
Author(s):  
Vanessa Castelli ◽  
Michele d’Angelo ◽  
Francesca Lombardi ◽  
Margherita Alfonsetti ◽  
Andrea Antonosante ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Disease Models

scholarly journals Neuroprotective effects of Danshensu on rotenone-induced Parkinson’s disease models in vitro and in vivo

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Tian Wang ◽  
Cuiting Li ◽  
Bing Han ◽  
Zhenhua Wang ◽  
Xiaoyu Meng ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Disease Models ◽  
Neuroprotective Effects

miR-494-3p modulates the progression of in vitro and in vivo Parkinson’s disease models by targeting SIRT3

2018 ◽  
Vol 675 ◽  
pp. 23-30 ◽  
Author(s):  
Lijiao Geng ◽  
Tao Zhang ◽  
Wei Liu ◽  
Yong Chen
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Disease Models

scholarly journals Anti-inflammatory effects of BHBA in both in vivo and in vitro Parkinson’s disease models are mediated by GPR109A-dependent mechanisms

2015 ◽  
Vol 12 (1) ◽  
pp. 9 ◽  
Author(s):  
Shou-Peng Fu ◽  
Jian-Fa Wang ◽  
Wen-Jing Xue ◽  
Hong-Mei Liu ◽  
Bing-run Liu ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Disease Models ◽  
Anti Inflammatory
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