Erratum to: The Role of Image-Guided Surgery in Breast Cancer

2013 ◽  
pp. E1-E1
Author(s):  
Kambiz Dowlatshahi ◽  
Rosalinda Alvarado ◽  
Katherine Kopckash
Keyword(s):  
Breast Cancer ◽  
Image Guided Surgery ◽  
Guided Surgery ◽  
Image Guided

The Role of Image-Guided Surgery in Breast Cancer

2013 ◽  
pp. 877-890 ◽  
Author(s):  
Kambiz Dowlatshahi ◽  
Rosalinda Alvarado ◽  
Katherine Kopckash
Keyword(s):  
Breast Cancer ◽  
Image Guided Surgery ◽  
Guided Surgery ◽  
Image Guided

scholarly journals Evaluation of EphB4 as Target for Image-Guided Surgery of Breast Cancer

2020 ◽  
Vol 13 (8) ◽  
pp. 172
Author(s):  
Cansu de Muijnck ◽  
Yoren van Gorkom ◽  
Maurice van Duijvenvoorde ◽  
Mina Eghtesadi ◽  
Geeske Dekker-Ensink ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Tyrosine Kinase ◽  
Breast Tissue ◽  
Normal Breast Tissue ◽  
Normal Breast ◽  
Her2 Status ◽  
Image Guided Surgery ◽  
Tyrosine Kinase Receptor ◽  
Guided Surgery ◽  
Image Guided

Background: Targeted image-guided surgery is based on the detection of tumor cells after administration of a radio-active or fluorescent tracer. Hence, enhanced binding of a tracer to tumor tissue compared to healthy tissue is crucial. Various tumor antigens have been evaluated as possible targets for image-guided surgery of breast cancer, with mixed results. Methods: In this study we have evaluated tyrosine kinase receptor EphB4, a member from the Eph tyrosine kinase receptor family, as a possible target for image-guided surgery of breast cancers. Two independent tissue micro arrays, consisting of matched sets of tumor and normal breast tissue, were stained for EphB4 by immunohistochemistry. The intensity of staining and the percentage of stained cells were scored by two independent investigators. Results: Immunohistochemical staining for EphB4 shows that breast cancer cells display enhanced membranous expression compared to adjacent normal breast tissue. The enhanced tumor staining is not associated with clinical variables like age of the patient or stage or subtype of the tumor, including Her2-status. Conclusion: These data suggest that EphB4 is a promising candidate for targeted image-guided surgery of breast cancer, especially for Her2 negative cases.

scholarly journals Current and Future Challenges in the Surgical Treatment of Hepatocellular Carcinoma: A Review

2014 ◽  
Vol 99 (6) ◽  
pp. 779-786 ◽  
Author(s):  
Georgios Tsoulfas ◽  
Polyxeni Agorastou ◽  
Andreas Tooulias ◽  
Georgios N. Marakis
Keyword(s):  
Hepatocellular Carcinoma ◽  
Image Guided Surgery ◽  
Significant Progress ◽  
Guided Surgery ◽  
Image Guided ◽  
Future Challenges ◽  
Technical Innovations ◽  
And Behavior ◽  
The Continuum

Abstract Challenges in the treatment of hepatocellular carcinoma Hepatocellular carcinoma (HCC) represents one of the most frequent types of cancer worldwide. Surgery, although only a part of the armamentarium against HCC, represents the cornerstone in the management of this aggressive disease. This article will review the current and future challenges in the surgical management of HCC, with a special emphasis on the following areas: (1) the evolution of staging of the disease and the importance of the biological nature and behavior of HCC, (2) the effort to increase resectability, (3) technical innovations and the role of image-guided surgery, and, finally, (4) the role of liver transplantation in the continuum of care for these patients. Although by no means an exhaustive list, the issues mentioned above represent some of the most promising prospects for significant progress in the management of HCC.

scholarly journals Fluorescent image-guided surgery in breast cancer by intravenous application of a quenched fluorescence activity-based probe for cysteine cathepsins in a syngeneic mouse model

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Frans V. Suurs ◽  
Si-Qi Qiu ◽  
Joshua J. Yim ◽  
Carolien P. Schröder ◽  
Hetty Timmer-Bosscha ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Molecular Imaging ◽  
Fluorescent Imaging ◽  
Image Guided Surgery ◽  
Time Points ◽  
Guided Surgery ◽  
Image Guided ◽  
Tumor Bearing ◽  
Camera Systems ◽  
Cysteine Cathepsins

Abstract Purpose The reoperation rate for breast-conserving surgery is as high as 15–30% due to residual tumor in the surgical cavity after surgery. In vivo tumor-targeted optical molecular imaging may serve as a red-flag technique to improve intraoperative surgical margin assessment and to reduce reoperation rates. Cysteine cathepsins are overexpressed in most solid tumor types, including breast cancer. We developed a cathepsin-targeted, quenched fluorescent activity-based probe, VGT-309, and evaluated whether it could be used for tumor detection and image-guided surgery in syngeneic tumor-bearing mice. Methods Binding specificity of the developed probe was evaluated in vitro. Next, fluorescent imaging in BALB/c mice bearing a murine breast tumor was performed at different time points after VGT-309 administration. Biodistribution of VGT-309 after 24 h in tumor-bearing mice was compared to control mice. Image-guided surgery was performed at multiple time points tumors with different clinical fluorescent camera systems and followed by ex vivo analysis. Results The probe was specifically activated by cathepsins X, B/L, and S. Fluorescent imaging revealed an increased tumor-to-background contrast over time up to 15.1 24 h post probe injection. In addition, VGT-309 delineated tumor tissue during image-guided surgery with different optical fluorescent imaging camera systems. Conclusion These results indicate that optical fluorescent molecular imaging using the cathepsin-targeted probe, VGT-309, may improve intraoperative tumor detection, which could translate to more complete tumor resection when coupled with commercially available surgical tools and techniques.

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