Biliary Epithelial Cells

2010 ◽  
pp. 27-51 ◽  
Author(s):  
Yoshiaki Mizuguchi ◽  
Susan Specht ◽  
Kumiko Isse ◽  
John G. Lunz ◽  
Anthony J. Demetris
Keyword(s):  
Epithelial Cells ◽  
Biliary Epithelial Cells

Ultrastructural Changes Associated with Alcoholic Hyalin in Hepatocytes and Biliary Epithelial Cells

1971 ◽  
Vol 29 ◽  
pp. 572-573
Author(s):  
Odell T. Minick ◽  
Hidejiro Yokoo ◽  
Fawzia Batti
Keyword(s):  
Endoplasmic Reticulum ◽  
Epithelial Cells ◽  
Liver Biopsy ◽  
Alcoholic Hepatitis ◽  
Ultrastructural Changes ◽  
Main Mass ◽  
Biliary Epithelial Cells ◽  
Biopsy Specimens ◽  
Alcoholic Hyalin

To learn more of the nature and origin of alcoholic hyalin (AH), 15 liver biopsy specimens from patients with alcoholic hepatitis were studied in detail.AH was found not only in hepatocytes but also in ductular cells (Figs. 1 and 2), although in the latter location only rarely. The bulk of AH consisted of a randomly oriented network of closely packed filaments measuring about 150 Å in width. Bundles of filaments smaller in diameter (40-90 Å) were observed along the periphery of the main mass (Fig. 1), often surrounding it in a rim-like fashion. Fine filaments were also found close to the nucleus in both hepatocytes and biliary epithelial cells, the latter even though characteristic AH was not present (Figs. 3 and 4). Dispersed among the larger filaments were glycogen, RNA particles and profiles of endoplasmic reticulum. Dilated cisternae of endoplasmic reticulum were often conspicuous around the periphery of the AH mass. A limiting membrane was not observed.

Epithelial-mesenchymal transition of biliary epithelial cells during cholestatic fibrosis

2007 ◽  
Vol 45 (01) ◽  
Author(s):  
F Schulze ◽  
E Konze ◽  
K Petmecky ◽  
K Schardt ◽  
O Dirsch ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Epithelial Mesenchymal Transition ◽  
Mesenchymal Transition ◽  
Biliary Epithelial Cells

scholarly journals Efficient functional cyst formation of biliary epithelial cells using microwells for potential bile duct organisation in vitro

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Astia Rizki-Safitri ◽  
Marie Shinohara ◽  
Yasushi Miura ◽  
Mathieu Danoy ◽  
Minoru Tanaka ◽  
...  
Keyword(s):  
Bile Duct ◽  
Epithelial Cells ◽  
Cyst Formation ◽  
Biliary Epithelial Cells

Genetic Lineage Tracing of Biliary Epithelial Cells

2018 ◽  
pp. 45-57 ◽  
Author(s):  
Teresa Rubio-Tomás ◽  
Beatriz Aguilar-Bravo ◽  
Pau Sancho-Bru
Keyword(s):  
Epithelial Cells ◽  
Lineage Tracing ◽  
Genetic Lineage ◽  
Biliary Epithelial Cells ◽  
Genetic Lineage Tracing

scholarly journals Regulation of Purinergic Signaling in Biliary Epithelial Cells by Exocytosis of SLC17A9-dependent ATP-enriched Vesicles

2011 ◽  
Vol 286 (28) ◽  
pp. 25363-25376 ◽  
Author(s):  
Meghana N. Sathe ◽  
Kangmee Woo ◽  
Charles Kresge ◽  
Abhijit Bugde ◽  
Kate Luby-Phelps ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Purinergic Signaling ◽  
Biliary Epithelial Cells

scholarly journals NCK-associated protein 1 like (nckap1l) minor splice variant regulates intrahepatic biliary network morphogenesis

PLoS Genetics ◽  
2021 ◽  
Vol 17 (3) ◽  
pp. e1009402
Author(s):  
Kimia Ghaffari ◽  
Lain X. Pierce ◽  
Maria Roufaeil ◽  
Isabel Gibson ◽  
Kevin Tae ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Network Formation ◽  
Stop Codon ◽  
Cell Lineage ◽  
Adaptor Protein ◽  
Specific Protein ◽  
Chemical Mutagenesis ◽  
Biliary Epithelial Cells ◽  
Regulatory Complex ◽  
Splice Isoform

Impaired formation of the intrahepatic biliary network leads to cholestatic liver diseases, which are frequently associated with autoimmune disorders. Using a chemical mutagenesis strategy in zebrafish combined with computational network analysis, we screened for novel genes involved in intrahepatic biliary network formation. We positionally cloned a mutation in thenckap1lgene, which encodes a cytoplasmic adaptor protein for the WAVE regulatory complex. The mutation is located in the last exon after the stop codon of the primary splice isoform, only disrupting a previously unannotated minor splice isoform, which indicates that the minor splice isoform is responsible for the intrahepatic biliary network phenotype. CRISPR/Cas9-mediatednckap1ldeletion, which disrupts both the primary and minor isoforms, showed the same defects. In the liver ofnckap1lmutant larvae, WAVE regulatory complex component proteins are degraded specifically in biliary epithelial cells, which line the intrahepatic biliary network, thus disrupting the actin organization of these cells. We further show thatnckap1lgenetically interacts with the Cdk5 pathway in biliary epithelial cells. These data together indicate that althoughnckap1lwas previously considered to be a hematopoietic cell lineage-specific protein, its minor splice isoform acts in biliary epithelial cells to regulate intrahepatic biliary network formation.

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