p63 in Squamous Differentiation and Cancer

2010 ◽  
pp. 241-259
Author(s):  
Dennis R. Roop ◽  
Maranke I. Koster
Keyword(s):  
Squamous Differentiation

Two cases of malignant eccrine tumors with squamous differentiation.

1990 ◽  
Vol 52 (1) ◽  
pp. 60-64 ◽  
Author(s):  
Mamoru KOHDA ◽  
Kozo URAKAMI ◽  
Masako YOKOO ◽  
Hiroaki UEKI
Keyword(s):  
Squamous Differentiation

Relationship between morular metaplasia and squamous differentiation in endometrial carcinoma

2021 ◽  
Vol 217 ◽  
pp. 153307
Author(s):  
Antonio Travaglino ◽  
Antonio Raffone ◽  
Annarita Gencarelli ◽  
Diego Raimondo ◽  
Paola Moretta ◽  
...  
Keyword(s):  
Endometrial Carcinoma ◽  
Squamous Differentiation

Gastric-type cervical adenocarcinoma with squamous differentiation: buried in adenosquamous carcinomas?

2021 ◽  
Author(s):  
Hiroshi Yoshida ◽  
Tomoaki Naka ◽  
Mayumi Kobayashi-Kato ◽  
Nao Kikkawa ◽  
Yasuhito Tanase ◽  
...  
Keyword(s):  
Cervical Adenocarcinoma ◽  
Squamous Differentiation ◽  
Gastric Type

scholarly journals Challenging Diagnosis in NUT Carcinoma

2021 ◽  
pp. 106689692110195
Author(s):  
Grosse Claudia ◽  
Grosse Alexandra
Keyword(s):  
Nuclear Protein ◽  
Hematological Malignancy ◽  
Undifferentiated Carcinoma ◽  
Squamous Differentiation ◽  
Poorly Differentiated Carcinoma ◽  
Poorly Differentiated ◽  
Nut Carcinoma ◽  
Disseminated Disease ◽  
Generation Sequencing

Nuclear protein in testis (NUT) carcinoma represents a highly aggressive, poorly differentiated carcinoma that is genetically defined by rearrangement of NUT gene. The histomorphological appearance ranges from entirely undifferentiated carcinoma to carcinoma with prominent squamous differentiation. NUT carcinoma can display neuroendocrine features. Although it is typically distributed along the midline axis, it may manifest in nonmidline locations. The majority of patients develop rapidly disseminated disease. We illustrate 2 cases of NUT carcinoma, one located in the lung, which closely resembled a neuroendocrine carcinoma, and the other one with assumed lung origin demonstrating metastatic dissemination with diffuse bone involvement, which was clinically first suspected to be a hematological malignancy. Due to its undifferentiated nature, NUT carcinoma may be confused with many entities. NUT immunohistochemistry is considered to be sufficient for the diagnosis. Fluorescence in-situ hybridization analysis and next-generation sequencing are currently used to confirm the diagnosis.

scholarly journals Molecular cloning of gene sequences regulated during squamous differentiation of tracheal epithelial cells and controlled by retinoic acid.

1987 ◽  
Vol 7 (11) ◽  
pp. 4017-4023 ◽  
Author(s):  
H L Smits ◽  
E E Floyd ◽  
A M Jetten
Keyword(s):  
Retinoic Acid ◽  
Epithelial Cells ◽  
Cdna Library ◽  
Transforming Growth Factor Beta ◽  
Transforming Growth Factor ◽  
Squamous Differentiation ◽  
Squamous Cells ◽  
Tracheal Epithelial Cells ◽  
Molecular Events ◽  
Tracheal Epithelial

A cDNA library was constructed from polyadenylated RNA present in squamous differentiated rabbit tracheal epithelial cells. Screening of the cDNA library was aimed at identifying RNAs that were abundant in squamous cells and expressed at low levels in undifferentiated cells. Two different recombinants were obtained containing inserts, 0.86 and 0.77 kilobases (kb) in size, that hybridized to mRNAs 1.0 and 1.25 kb in length. These RNAs were present at approximately 50-fold higher levels in squamous cells than in proliferative or confluent retinoic acid-treated cells. The increase in the levels of the 1.0- and 1.25-kb RNAs correlated closely with the onset of squamous differentiation and was not related to induction of terminal cell division. Treatment of rabbit tracheal epithelial cells with transforming growth factor beta, which induces squamous differentiation in these cells, also resulted in elevated levels of the 1.0- and 1.25-kb RNAs. The increased levels of these RNAs in squamous cells appeared to a large extent to be regulated at a posttranscriptional level. Retinoic acid not only inhibited the increase in the levels of the 1.0- and 1.25-kb RNAs but also reversed the expression of these RNAs in squamous cells. These results suggest that retinoic acid affects, directly or indirectly, molecular events that induce alterations in the posttranscriptional processing of the transcripts corresponding to the 1.0- and 1.25-kb RNAs.

Aberrant Cdx2 expression in endometrial lesions with squamous differentiation: important role of Cdx2 in squamous morula formation

2008 ◽  
Vol 39 (7) ◽  
pp. 1072-1079 ◽  
Author(s):  
Yoji Wani ◽  
Kenji Notohara ◽  
Makoto Saegusa ◽  
Choutatsu Tsukayama
Keyword(s):  
Squamous Differentiation ◽  
Cdx2 Expression

Prognostic Value of Squamous Differentiation in Upper Tract Urothelial Carcinoma Treated With Radical Nephroureterectomy

2021 ◽  
Vol 42 (1) ◽  
pp. 263-269
Author(s):  
AKINORI MINATO ◽  
HIROTSUGU NOGUCHI ◽  
RIEKO KIMURO ◽  
HARADA MIRII ◽  
NAGATA YUJIRO ◽  
...  
Keyword(s):  
Urothelial Carcinoma ◽  
Prognostic Value ◽  
Upper Tract Urothelial Carcinoma ◽  
Radical Nephroureterectomy ◽  
Squamous Differentiation ◽  
Upper Tract

Squamous Differentiation in a Sarcomatoid Chromophobe Renal Cell Carcinoma: An Unusual Case Report With Review of the Literature

2008 ◽  
Vol 132 (10) ◽  
pp. 1672-1674
Author(s):  
Seethalakshmi Viswanathan ◽  
Sangeeta B. Desai ◽  
S. R. Prabhu ◽  
Mahul B. Amin
Keyword(s):  
Renal Cell Carcinoma ◽  
Case Report ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Unusual Case ◽  
Chromophobe Renal Cell Carcinoma ◽  
Rare Occurrence ◽  
Review Of The Literature ◽  
Squamous Differentiation ◽  
Unusual Case Report

Abstract We describe an extremely rare occurrence of a squamous differentiation in a sarcomatoid chromophobe renal cell carcinoma in a 45-year-old woman with nodal and lung metastasis at presentation. The tumor on histology showed all 3 components intimately admixed with each other, which to the best of our knowledge is the first such case to be reported in the literature. The renal pelvis was smooth walled and uninvolved. Kidney-specific cadherin was positive in the chromophobe renal cell carcinoma areas and negative in the sarcomatoid and squamous areas.

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