Gastric-type cervical adenocarcinoma with squamous differentiation: buried in adenosquamous carcinomas?

2021 ◽  
Author(s):  
Hiroshi Yoshida ◽  
Tomoaki Naka ◽  
Mayumi Kobayashi-Kato ◽  
Nao Kikkawa ◽  
Yasuhito Tanase ◽  
...  
Keyword(s):  
Cervical Adenocarcinoma ◽  
Squamous Differentiation ◽  
Gastric Type

scholarly journals A Retrospective Study on Incidence, Diagnosis, and Clinical Outcome of Gastric-type Endocervical Adenocarcinoma in a Single Institution

2021 ◽  
Author(s):  
Anna Radomska ◽  
Daniel Lee ◽  
Heather Neufeld ◽  
Nancy Korte ◽  
Emina Torlakovic ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Kinase Inhibitor ◽  
P53 Protein ◽  
Progesterone Receptors ◽  
Cervical Adenocarcinoma ◽  
Single Institution ◽  
Mutant Type ◽  
Usual Type ◽  
Endocervical Adenocarcinoma ◽  
Gastric Type

Abstract Background: Gastric-type endocervical adenocarcinoma is rare but the most common subtype of cervical adenocarcinoma not associated with human papillomavirus. It is more aggressive with a shorter five-year survival rate compared to human papillomavirus-associated usual type endocervical adenocarcinoma. The objectives of our study were to determine the incidence and clinical-pathological characteristics of Gastric-type endocervical adenocarcinoma in a single institution. Methods: Twenty four cases of invasive cervical adenocarcinoma were identified between January 2000 and December 2015, from the Saskatoon Health Region pathology database using International Endocervical Adenocarcinoma Criteria and Classification to retrospectively classify endocervical adenocarcinoma. Immunohistochemistry was performed with antibodies for Gastric mucin-6 (MUC-6), p16INK4a, cyclin-dependent kinase inhibitor 2A (p16), p53 protein (p53), estrogen and progesterone receptors. Clinical and pathological data was retrieved from pathology reports and charts. Statistical analysis was performed using Mann-Whitney U test and Chi-Square test.Results: Using the International Endocervical Adenocarcinoma Criteria and Classification criteria, 19 cases (79.2%) were classified as human papillomavirus-associated usual type endocervical adenocarcinoma, and five cases (20.8%) as Gastric-type endocervical adenocarcinoma. In our study 40% of Gastric-type endocervical adenocarcinoma cases presented at stage III compared to none of the usual type endocervical carcinoma cases. All the Gastric-type endocervical adenocarcinoma cases were positive for MUC-6, and negative for p16. 60% Gastric-type endocervical adenocarcinoma cases demonstrated mutant type p53 staining. In contrast, 84.2% of human papillomavirus-associated usual type endocervical adenocarcinoma cases showed block like nuclear and cytoplasmic positivity with p16 antibodies. The Gastric-type endocervical adenocarcinoma group had significantly shorter median survival time than human papillomavirus-associated usual type endocervical adenocarcinoma group, Gastric-type endocervical adenocarcinoma is 22 months compared to human papillomavirus-associated usual type endocervical adenocarcinoma at 118 months (p = 0.043). Conclusions: In this study, Gastric-type endocervical adenocarcinoma accounted for 20.8% of all cervical adenocarcinoma with higher stage at presentation and shorter overall survival. Histomorphology and immunohistochemistry for MUC-6 and p16 could differentiate between Gastric-type endocervical adenocarcinoma and human papillomavirus-associated usual type endocervical adenocarcinoma.

scholarly journals Abstract 2930: Characterization based on therapeutic target biomarkers of patients-driven xenografts model of gastric-type cervical adenocarcinoma

2021 ◽  
Author(s):  
Yuki Kojima ◽  
Hiroshi Yoshida ◽  
Toshihiro Okuya ◽  
Hitomi S. Okuma ◽  
Tadaaki Nishikawa ◽  
...  
Keyword(s):  
Therapeutic Target ◽  
Cervical Adenocarcinoma ◽  
Gastric Type

Cytomorphology of Gastric-Type Cervical Adenocarcinoma on a ThinPrep Pap Test: Report of a p16-Positive Tumor Case

2016 ◽  
Vol 44 (8) ◽  
pp. 710-713 ◽  
Author(s):  
Clifton G. Fulmer ◽  
Rana S. Hoda ◽  
Edyta C. Pirog ◽  
Kay J. Park ◽  
Kevin Holcomb
Keyword(s):  
Pap Test ◽  
Cervical Adenocarcinoma ◽  
Test Report ◽  
Gastric Type

scholarly journals A Tumor of Composite Cervical Adenocarcinoma with MUCIN Gene Mutation：A Case Report

2021 ◽  
Author(s):  
Meijun Guo ◽  
Guoping Li ◽  
Xiuxiu Jiang ◽  
Shiming Lv
Keyword(s):  
Cervical Cancer ◽  
Gene Mutations ◽  
Gene Sequencing ◽  
Enrichment Analysis ◽  
Cervical Adenocarcinoma ◽  
Cervical Lesions ◽  
Transitional Area ◽  
Mucin Gene ◽  
Gastric Type ◽  
Minimal Deviation

Abstract Background:There are reports about the coexistence of two kinds of tumors in the same patient,which is believed that this phenomenon is caused by the dedifferentiation between the two tumors.In this paper, we report an human papillomavirus (HPV) negative cervical adenocarcinoma in a patient composed of two adenocarcinoma components,which is first reported.Histologically, both minimal deviation adenocarcinoma (MDA) and poorly differentiated gastric type adenocarcinoma (GTA) components, as well as their transitional area, were observed.Methods:This case of cervical cancer was screened by gene sequencing. For detection of specific somatic mutations in MDA and GTA, we filtered out mutations in malignant cervical cancer blood sample and 7 common cervical carcinoma. Then the genes were screened and identified based on the enrichment analysis of GO and KEGG and related literature reports. Results:We found 13 specific somatic gene mutations in total. Among these genes, only Mucin gene was transformed from gene level to protein level, and was positive in both MDA and GTA components of the patient by immunohistochemistry.Both components had genes mutation of MUC4 and MUC17,the component in MDA had gene mutation of MUC3A,and we found that MUC3A and MUC17 were on the same chromosome. Moreover,MUC3A and MUC4 genes were found to be fused in FusionGDB database. Conclusion:According to the reports of MUC3A,MUC4 and MUC17 genes mutation in cervical adenocarcinoma and gene fusions in tumorigenesis, we speculate that the occurrence of the transformation of pathological type from MDA to GTA in this case of cervical cancer is related to the mechanism of MUC3A and MUC4 gene fusion.We would advice, for HPV negative or atypical cervical lesions, immunohistochemistry of MUCIN genes staining and gene sequencing should be considered, which may find unusual cancer types and change the prognosis of patients.

scholarly journals Morphologic Features of Gastric-type Cervical Adenocarcinoma in Small Surgical and Cytology Specimens

2019 ◽  
Vol 38 (3) ◽  
pp. 263-275 ◽  
Author(s):  
Gulisa Turashvili ◽  
Elizabeth G. Morency ◽  
Mihaela Kracun ◽  
Deborah F. DeLair ◽  
Sarah Chiang ◽  
...  
Keyword(s):  
Cervical Adenocarcinoma ◽  
Gastric Type

scholarly journals A retrospective study on incidence, diagnosis, and clinical outcome of gastric-type endocervical adenocarcinoma in a single institution

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Anna Radomska ◽  
Daniel Lee ◽  
Heather Neufeld ◽  
Nancy Korte ◽  
Emina Torlakovic ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Kinase Inhibitor ◽  
P53 Protein ◽  
Progesterone Receptors ◽  
Cervical Adenocarcinoma ◽  
Single Institution ◽  
Mutant Type ◽  
Usual Type ◽  
Endocervical Adenocarcinoma ◽  
Gastric Type

Abstract Background Gastric-type endocervical adenocarcinoma is rare but the most common subtype of cervical adenocarcinoma not associated with human papillomavirus. It is more aggressive with a shorter five-year survival rate compared to human papillomavirus-associated usual type endocervical adenocarcinoma. The objectives of our study were to determine the incidence and clinical-pathological characteristics of Gastric-type endocervical adenocarcinoma in a single institution. Methods Twenty four cases of invasive cervical adenocarcinoma were identified between January 2000 and December 2015, from the Saskatoon Health Region pathology database using International Endocervical Adenocarcinoma Criteria and Classification to retrospectively classify endocervical adenocarcinoma. Immunohistochemistry was performed with antibodies for Gastric mucin-6 (MUC-6), p16INK4a, cyclin-dependent kinase inhibitor 2A (p16), p53 protein (p53), estrogen and progesterone receptors. Clinical and pathological data was retrieved from pathology reports and charts. Statistical analysis was performed using Mann-Whitney U test and Chi-Square test. Results Using the International Endocervical Adenocarcinoma Criteria and Classification criteria, 19 cases (79.2%) were classified as human papillomavirus-associated usual type endocervical adenocarcinoma, and five cases (20.8%) as Gastric-type endocervical adenocarcinoma. In our study 40% of Gastric-type endocervical adenocarcinoma cases presented at stage III compared to none of the usual type endocervical carcinoma cases. All the Gastric-type endocervical adenocarcinoma cases were positive for MUC-6, and negative for p16. 60% Gastric-type endocervical adenocarcinoma cases demonstrated mutant type p53 staining. In contrast, 84.2% of human papillomavirus-associated usual type endocervical adenocarcinoma cases showed block like nuclear and cytoplasmic positivity with p16 antibodies. The Gastric-type endocervical adenocarcinoma group had significantly shorter median survival time than human papillomavirus-associated usual type endocervical adenocarcinoma group, Gastric-type endocervical adenocarcinoma is 22 months compared to human papillomavirus-associated usual type endocervical adenocarcinoma at 118 months (p = 0.043). Conclusions In this study, Gastric-type endocervical adenocarcinoma accounted for 20.8% of all cervical adenocarcinoma with higher stage at presentation and shorter overall survival. Criteria proposed by International Endocervical Adenocarcinoma Criteria and Classification (IECC) are simple and reproducible in differentiating between, HPV- associated (HPVA) and non HPV associated (NHPVA) endocervical adenocarcinoma. Although none of the IHC assays is specific for GAS, but p16, MUC-6, ER, PR and p53 may further aid in confirming GAS and to differentiate it from benign and malignant mimics.

scholarly journals αGlcNAc and its catalyst α4GnT are diagnostic and prognostic markers in uterine cervical tumor, gastric type

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Koichi Ida ◽  
Kazuhiro Yamanoi ◽  
Shiho Asaka ◽  
Hodaka Takeuchi ◽  
Tsutomu Miyamoto ◽  
...  
Keyword(s):  
Who Classification ◽  
Prognostic Markers ◽  
Hpv Infection ◽  
Cervical Adenocarcinoma ◽  
Prognostic Indicators ◽  
Cervical Tumor ◽  
Conventional Chemotherapy ◽  
Papilloma Virus ◽  
Favorable Prognosis ◽  
Gastric Type

Abstract Cervical adenocarcinoma, gastric type (GAS) is not associated with human papilloma virus (HPV) infection. GAS patients prognoses are significantly worse compared with cervical adenocarcinoma associated with HPV infection, as their tumors exhibit resistance to conventional chemotherapy and radiotherapy. GAS is often associated with lobular endocervical glandular hyperplasia (LEGH), which is regarded as a precursor to GAS in the latest WHO classification. Recently, we reported that a decrease in expression of terminal α1,4-linked N-acetylglucosamine (αGlcNAc) relative to that of MUC6 was already apparent in atypical LEGH in the LEGH-GAS sequence. Here, we analyzed expression of α1,4-N-acetylglucosaminyltransferase (α4GnT), the sole enzyme catalyzing αGlcNAc biosynthesis, and that of αGlcNAc and MUC6 in cases representing non-neoplastic endocervical gland (NNEG) (11 cases), LEGH (26 cases) and GAS (12 cases). α4GnT protein was detected in a “dot-like” pattern, indicating localization in the Golgi apparatus in all 26 LEGH cases and 5 of 12 GAS cases. α4GnT- and αGlcNAc-positive cells largely overlapped, suggesting that α4GnT gene expression regulates αGlcNAc biosynthesis. Interestingly, all NNEG cases were negative for α4GnT and αGlcNAc expression, but 7 of 11 NNEG and all LEGH cases were MUC6-positive. In GAS cases, patients whose tumors were α4GnT- and αGlcNAc-positive had more favorable prognosis than others. Multivariate analysis revealed that positive expressions of α4GnT and αGlcNAc were independent prognostic indicators. These results indicate that α4GnT and αGlcNAc could serve as useful markers not only to distinguish LEGH from NNEG but to evaluate prognoses of GAS patients.

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