Predictive Markers in Lung Cancer

2012 ◽  
pp. 43-68
Author(s):  
Stephen V. Liu ◽  
Barbara J. Gitlitz

2009 ◽  
Vol 4 (7) ◽  
pp. 891-910 ◽  
Author(s):  
Ana Belén Custodio ◽  
José Luis González-Larriba ◽  
Jana Bobokova ◽  
Antonio Calles ◽  
Rafael Álvarez ◽  
...  


2021 ◽  
Vol 16 (10) ◽  
pp. S1083
Author(s):  
R. Rhone ◽  
L. Raez ◽  
K. Dumais ◽  
H. Powery ◽  
F. Gentile


BMC Cancer ◽  
2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Wolfgang M. Brueckl ◽  
Joachim H. Ficker ◽  
Gloria Zeitler

Abstract Background Immune checkpoint inhibitors (ICI) either alone or in combination with chemotherapy have expanded our choice of agents for the palliative treatment of non-small cell lung cancer (NSCLC) patients. Unfortunately, not all patients will experience favorable response to treatment with ICI and may even suffer from severe side effects. Therefore, prognostic and predictive markers, beyond programmed death ligand 1 (PD-L1) expression status, are of utmost importance for decision making in the palliative treatment. This review focuses on clinical, laboratory and genetic markers, most of them easily to obtain in the daily clinical practice. Results Recently, a number of prognostic and predictive factors in association to palliative ICI therapy have been described in NSCLC. Besides biometric parameters and clinical characteristics of the tumor, there are useful markers from routine blood sampling as well as innovative soluble genetic markers which can be determined before and during ICI treatment. Additionally, the level of evidence is noted. Conclusions These factors can be helpful to predict patients’ outcome and tumor response to ICI. They should be implemented prospectively in ICI based clinical trials to develop reliable algorithms for palliative NSCLC treatment.



2012 ◽  
Vol 23 ◽  
pp. ix76
Author(s):  
A. Pircher ◽  
G. Untergasser ◽  
I.M. Heidegger ◽  
J. Kern ◽  
E. Gunsilius ◽  
...  


Lung Cancer ◽  
2015 ◽  
Vol 88 (3) ◽  
pp. 246-253 ◽  
Author(s):  
Ying Wu ◽  
Hongbing Liu ◽  
Xuefei Shi ◽  
Yong Song


2018 ◽  
Vol 36 (15_suppl) ◽  
pp. e21158-e21158
Author(s):  
Isabel Ruth Preeshagul ◽  
Kevin M. Sullivan ◽  
Doru Paul ◽  
Robert G. Maki ◽  
Nagashree Seetharamu




2009 ◽  
Vol 8 (3) ◽  
pp. 206-212 ◽  
Author(s):  
Vincenzo Adamo ◽  
Tindara Franchina ◽  
Barbara Adamo ◽  
Nerina Denaro ◽  
Pietro Gambadauro ◽  
...  


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