Great Myths of Blood Pressure Effect Size in Renal Denervation

2014 ◽  
pp. 175-180
Author(s):  
James P. Howard ◽  
Matthew J. Shun-Shin ◽  
Darrel P. Francis
Nutrients ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 4560
Author(s):  
Alicia Gea Cabrera ◽  
Pablo Caballero ◽  
Carmina Wanden-Berghe ◽  
María Sanz-Lorente ◽  
Elsa López-Pintor

Workplace health interventions are essential to improve the health and well-being of workers and promote healthy lifestyle behaviours. We carried out a systematic review, meta-analysis and meta-regression of articles measuring the association between workplace dietary interventions and MetS risk. We recovered potentially eligible studies by searching MEDLINE, the Cochrane Library, Embase, Scopus and Web of Science, using the terms “Metabolic syndrome” and “Occupational Health”. A total of 311 references were retrieved and 13 documents were selected after applying the inclusion and exclusion criteria. Dietary interventions were grouped into six main types: basic education/counselling; specific diet/changes in diet and food intake; behavioural change/coaching; physical exercise; stress management; and internet/social networks. Most programmes included several components. The interventions considered together are beneficial, but the clinical results reflect only a minimal impact on MetS risk. According to the metaregression, the interventions with the greatest impact were those that used coaching techniques and those that promoted physical activity, leading to increased HDL (effect size = 1.58, sig = 0.043; and 2.02, 0.015, respectively) and decreased BMI (effect size = −0.79, sig = −0.009; and −0.77, 0.034, respectively). In contrast, interventions offering information on healthy habits and lifestyle had the contrary effect, leading to increased BMI (effect size = 0.78, sig = 0.006), systolic blood pressure (effect size = 4.85, sig = 0.038) and diastolic blood pressure (effect size = 3.34, sig = 0.001). It is necessary to improve the efficiency of dietary interventions aimed at lowering MetS risk in workers.


1974 ◽  
Vol 48 (s2) ◽  
pp. 299s-302s ◽  
Author(s):  
A. Mimran ◽  
D. Casellas ◽  
M. Dupont ◽  
P. Barjon

1. Inhibition of prostaglandin synthesis by indomethacin induced an increase in blood pressure which did not occur when rats were bilaterally nephrectomized. 2. The blood pressure effect was related to the state of sodium balance and thus to the activity of the renin-angiotensin system. 3. Indomethacin induced a decrease in renal blood flow. 4. Angiotensin receptor blockade with Sar1-Ala8-angiotensin II blunted the blood pressure effect and prevented the renal haemodynamic changes induced by indomethacin.


2004 ◽  
Vol 287 (6) ◽  
pp. R1394-R1398 ◽  
Author(s):  
Dexter L. Lee ◽  
R. Clinton Webb ◽  
Michael W. Brands

The goal of this study was to determine the dependence of the acute hypertensive response to a novel model of acute psychosocial stress on the sympathetic and renin-angiotensin systems. Baseline mean arterial pressure (MAP), heart rate (HR), and locomotor activity were measured with telemetry in mice for a 1-h period and averaged 98 ± 1 mmHg, 505 ± 3 beats/min, and 5 ± 1 counts, respectively. Stress was induced by placing a mouse into a cage previously occupied by a different male mouse, and this increased MAP, HR, and activity in the control group by 40 ± 2 mmHg, 204 ± 25 beats/min, and 68 ± 6 counts, respectively. Each variable gradually returned to baseline levels by 90 min after beginning cage switch. Pretreatment with terazosin (10 mg/kg ip) significantly reduced the initial increase in MAP to 12 ± 6 mmHg, whereas MAP for the last 45 min was superimposable on control values. Atenolol (10 mg/ml drinking water) had no effect to blunt the initial increase in MAP but had a growing effect from 10 min onward, decreasing MAP all the way to baseline by 60 min after starting cage switch. Captopril (2 mg/ml drinking water) treatment caused a very similar response. All three treatments significantly decreased the area under the blood pressure curve, and the blood pressure effect could not be attributed uniformly to effects on HR or activity. These data suggest that our novel model of psychosocial stress causes an initial α1-receptor-dependent increase in MAP. The later phase of the pressor response is blocked similarly by a β1-receptor antagonist and an ACE inhibitor, independent of HR, suggesting that the β1-dependent blood pressure effect is due, in large part, to the renin-angiotensin system.


Hypertension ◽  
1997 ◽  
Vol 29 (6) ◽  
pp. 1225-1231 ◽  
Author(s):  
Stephen N. Hunyor ◽  
Robyn J. Henderson ◽  
Saroj K. L. Lal ◽  
Norman L. Carter ◽  
Henry Kobler ◽  
...  

Author(s):  
Michael Young ◽  
Karen Jansen ◽  
Tim Gould ◽  
Coralynn Sack ◽  
Laura Hooper ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document