Iron Quantification by Non-Invasive Biomagnetic Organ Susceptometry

Biomag 96 ◽  
2000 ◽  
pp. 647-650
Author(s):  
R. Engelhardt ◽  
R. Fischer ◽  
P. Nielsen ◽  
E. E. Gabbe
Keyword(s):  
Non Invasive ◽  
Iron Quantification

Multi-Centre Validation of the Cardiovascular Magnetic Resonance Multi Breath-Hold T2* Technique for Myocardial Iron Quantification in Thalassaemia Major.

Blood ◽  
2005 ◽  
Vol 106 (11) ◽  
pp. 3828-3828
Author(s):  
Mark A. Tanner ◽  
Taigang He ◽  
Mark A. Westwood ◽  
Renzo Galanello ◽  
Gildo Matta ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Iron Overload ◽  
Breath Hold ◽  
Myocardial Iron ◽  
Thalassaemia Major ◽  
Non Invasive ◽  
Cardiac Siderosis ◽  
Iron Quantification ◽  
Siemens Sonata ◽  
Roll Out

Abstract Introduction: Beta thalassaemia major (TM) is a hereditary anaemia affecting 60 000 births worldwide each year. Survival is dependent upon lifelong blood transfusions resulting in iron overload. Cardiac siderosis can result in a cardiomyopathy which is the leading cause of death in TM. The validated cardiac magnetic resonance (CMR) T2* technique allows non-invasive and reproducible quantification of myocardial iron. Assessment of myocardial iron loading is essential in determining appropriate chelation therapy. This technique has the potential to become the new gold standard in the assessment of cardiac siderosis but is currently available at only a few sites worldwide. For maximal healthcare benefit its inter-scanner reproducibility must be demonstrated before being widely disseminated. Objective: To demonstrate that CMR T2* quantification of myocardial iron can be reproducibly transferred to MR scanners of different manufacturers in different centres. This project was sponsored by the Thalassemia International Federation. Methods: The previously described multi breath-hold gradient echo T2* technique was installed on MR scanners (all 1.5Tesla) at 6 different centres. Scanner details were as follows: Site 1, Phillips Intera (Turin, Italy), Site 2, Siemens Sonata (Philadelphia, USA), Site 3 GE Signa (Limassol, Cyprus) Site 4, Phillips Intera (Nicosia, Cyprus), Site 5, GE Signa (Cagliari, Sardinia) and Philips Intera (Genova, Italy). 34 patients (mean age 30+/− 5.7years) were scanned in total. All patients were subsequently re-scanned at the standardization centre in London, UK (Siemens Sonata, 1.5T) within 31 days of their original scan. Results: The T2* sequence was successfully installed on all 6 scanners. Myocardial T2* values ranged from 3.6ms to 51ms (14.2 +/− 11ms). The overall inter-scanner reproducibility (SD/mean) was 5.3% (figure 1). The mean difference between T2* values at the standardization centre and visited sites was 0.32ms. Conclusion: We have demonstrated that the multi breath-hold T2* technique for the quantification of myocardial iron can be reproducibly transferred to 1.5T MR scanners at different sites and of different manufacturers. There is therefore real potential to roll out this technique worldwide to facilitate maximal healthcare impact in the management of patients with iron overload conditions such as thalassaemia. Figure Figure

Iron Deficiency in Distance Runners A Reinvestigation Using 59Fe-Labelling and Non-Invasive Liver Iron Quantification

1996 ◽  
Vol 17 (07) ◽  
pp. 473-479 ◽  
Author(s):  
D. Nachtigall ◽  
P. Nielsen ◽  
R. Fischer ◽  
R. Engelhardt ◽  
E. Gabbe
Keyword(s):  
Iron Deficiency ◽  
Distance Runners ◽  
Liver Iron ◽  
Non Invasive ◽  
Iron Quantification

scholarly journals Brain tissue iron quantification by MRI in intracerebral hemorrhage: Current translational evidence and pitfalls

2018 ◽  
Vol 39 (3) ◽  
pp. 562-564 ◽  
Author(s):  
Neeraj Chaudhary ◽  
Aditya S Pandey ◽  
Julius Griauzde ◽  
Joseph J Gemmete ◽  
Thomas L Chenevert ◽  
...  
Keyword(s):  
Animal Models ◽  
Intracerebral Hemorrhage ◽  
Brain Tissue ◽  
Hemorrhagic Stroke ◽  
Specific Treatment ◽  
Substantial Evidence ◽  
Non Invasive ◽  
Iron Quantification ◽  
Tissue Iron ◽  
Iron Based

Intracerebral hemorrhage (ICH) is a common subtype of hemorrhagic stroke with devastating consequences with no specific treatment. There is, however, substantial evidence for iron-mediated neurotoxicity in animal ICH models. Non-invasive quantification of the peri-hematomal tissue iron based on MRI has shown some promise in animal models and is being validated for clinical translation. This commentary reviews evidence for this approach and discusses potential pitfalls.

X-ray microtomography

1988 ◽  
Vol 46 ◽  
pp. 998-999
Author(s):  
H.W. Deckman ◽  
B.F. Flannery ◽  
J.H. Dunsmuir ◽  
K.D' Amico
Keyword(s):  
Computed Tomography ◽  
Internal Structure ◽  
Imaging Technique ◽  
Three Dimensional ◽  
Tissue Structure ◽  
Individual Element ◽  
X Ray ◽  
Non Invasive ◽  
Panoramic Imaging ◽  
Three Dimensional Images

We have developed a new X-ray microscope which produces complete three dimensional images of samples. The microscope operates by performing X-ray tomography with unprecedented resolution. Tomography is a non-invasive imaging technique that creates maps of the internal structure of samples from measurement of the attenuation of penetrating radiation. As conventionally practiced in medical Computed Tomography (CT), radiologists produce maps of bone and tissue structure in several planar sections that reveal features with 1mm resolution and 1% contrast. Microtomography extends the capability of CT in several ways. First, the resolution which approaches one micron, is one thousand times higher than that of the medical CT. Second, our approach acquires and analyses the data in a panoramic imaging format that directly produces three-dimensional maps in a series of contiguous stacked planes. Typical maps available today consist of three hundred planar sections each containing 512x512 pixels. Finally, and perhaps of most import scientifically, microtomography using a synchrotron X-ray source, allows us to generate maps of individual element.

Non-invasive measurement of a fermentation pattern shift in infants during the first three months of life

2001 ◽  
Vol 120 (5) ◽  
pp. A266-A266
Author(s):  
R BUTLER ◽  
B ZACHARAKIS ◽  
D MOORE ◽  
K CRAWFORD ◽  
G DAVIDSON ◽  
...  
Keyword(s):  
Non Invasive ◽  
Fermentation Pattern ◽  
Invasive Measurement

European multicentre validation trial of two new non-invasive tests for detection of antibody to H. pylori: Urine-based ELISA and rapid urine test

2001 ◽  
Vol 120 (5) ◽  
pp. A491-A491 ◽  
Author(s):  
A LEODOLTER ◽  
D VAIRA ◽  
F BAZZOLL ◽  
A HIRSCHL ◽  
F MEGRAUD ◽  
...  
Keyword(s):  
Urine Test ◽  
Non Invasive ◽  
H Pylori

Tu1996 NON-INVASIVE BREATH TEST SCREENING TO ASSESS FOR PREPROCEDURAL FASTING USING AN ELECTRONIC NOSE: AN UPDATE

2020 ◽  
Vol 158 (6) ◽  
pp. S-1249
Author(s):  
Yuri Hanada ◽  
Juan Reyes Genere ◽  
Bryan Linn ◽  
Tiffany Mangels-Dick ◽  
Kenneth K. Wang
Keyword(s):  
Electronic Nose ◽  
Breath Test ◽  
Non Invasive

1307: Renal Radiosurgery and Sorafenib as Non-Invasive Nephron-Sparing Treatment of Small Localized Renal Masses

2007 ◽  
Vol 177 (4S) ◽  
pp. 430-430
Author(s):  
Ram Ganapathi ◽  
Troy R. Gianduzzo ◽  
Arul Mahadevan ◽  
Monish Aron ◽  
Lee E. Ponsky ◽  
...  
Keyword(s):  
Renal Masses ◽  
Non Invasive ◽  
Nephron Sparing
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