Regulation and Function of Protein Tyrosine Kinase Syk in FcεRI-Mediated Signaling

1999 ◽  
pp. 115-133 ◽  
Author(s):  
Reuben P. Siraganian ◽  
Juan Zhang ◽  
Teruaki Kimura
Keyword(s):  
Tyrosine Kinase ◽  
Protein Tyrosine Kinase ◽  
Protein Tyrosine ◽  
And Function

The Atlantic salmon protein tyrosine kinase Tyk2: Molecular cloning, modulation of expression and function

2013 ◽  
Vol 41 (4) ◽  
pp. 553-563 ◽  
Author(s):  
Mehrdad Sobhkhez ◽  
Tom Hansen ◽  
Dimitar B. Iliev ◽  
Astrid Skjesol ◽  
Jorunn B. Jørgensen
Keyword(s):  
Atlantic Salmon ◽  
Tyrosine Kinase ◽  
Molecular Cloning ◽  
Protein Tyrosine Kinase ◽  
Protein Tyrosine ◽  
And Function

scholarly journals Restoration of Thymocyte Development and Function in zap-70−/− Mice by the Syk Protein Tyrosine Kinase

Immunity ◽  
1997 ◽  
Vol 7 (3) ◽  
pp. 369-377 ◽  
Author(s):  
Qian Gong ◽  
Lynn White ◽  
Robin Johnson ◽  
Mike White ◽  
Izumi Negishi ◽  
...  
Keyword(s):  
Tyrosine Kinase ◽  
Protein Tyrosine Kinase ◽  
Thymocyte Development ◽  
Protein Tyrosine ◽  
Syk Protein Tyrosine Kinase ◽  
And Function

Protein-tyrosine Kinase p72 syk Is Activated by Platelet Activating Factor in Platelets

1994 ◽  
Vol 72 (06) ◽  
pp. 937-941 ◽  
Author(s):  
Karim Rezaul ◽  
Shigeru Yanagi ◽  
Kiyonao Sada ◽  
Takanobu Taniguchi ◽  
Hirohei Yamamura
Keyword(s):  
Tyrosine Kinase ◽  
Tyrosine Phosphorylation ◽  
Protein Tyrosine Kinase ◽  
Kinase Inhibitor ◽  
Critical Role ◽  
Platelet Activating Factor ◽  
Kinase Assay ◽  
Potential Candidate ◽  
Protein Tyrosine ◽  
Induced Aggregation

SummaryIt has been demonstrated that activation of platelets by platelet-activating factor (PAF) results in a dramatic increase in tyrosine phosphorylation of several cellular proteins. We report here that p72 syk is a potential candidate for the protein-tyrosine phosphorylation following PAF stimulation in porcine platelets. Immunoprecipitation kinase assay revealed that PAF stimulation resulted in a rapid activation of p72 syk which peaked at 10 s. The level of activation was found to be dose dependent and could be completely inhibited by the PAF receptor antagonist, CV3988. Phosphorylation at the tyrosine residues of p72 syk coincided with activation of yllsyk. Pretreatment of platelets with aspirin and apyrase did not affect PAF induced activation of p72 syk .Furthermore, genistein, a potent protein-tyrosine-kinase inhibitor, diminished PAF-induced p72 syk activation and Ca2+ mobilization as well as platelet aggregation. These results suggest that p72 syk may play a critical role in PAF-induced aggregation, possibly through regulation of Ca2+ mobilization.

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