A Procedure for Detecting Similarity Between Distantly Related Protein Families

2000 ◽  
pp. 1275-1284
Author(s):  
Hiromi Suzuki ◽  
Satoshi Fukuchi ◽  
Katsuhisa Horimoto
Keyword(s):  
Related Protein ◽  
Protein Families

scholarly journals Evolution of polymer formation within the actin superfamily

2017 ◽  
Vol 28 (19) ◽  
pp. 2461-2469 ◽  
Author(s):  
Patrick R. Stoddard ◽  
Tom A. Williams ◽  
Ethan Garner ◽  
Buzz Baum
Keyword(s):  
Convergent Evolution ◽  
Atp Hydrolysis ◽  
Linear Polymers ◽  
Related Protein ◽  
Protein Families ◽  
Structure And Dynamics ◽  
Polymer Formation ◽  
Filament Structure ◽  
Related Proteins ◽  
Actin Superfamily

While many are familiar with actin as a well-conserved component of the eukaryotic cytoskeleton, it is less often appreciated that actin is a member of a large superfamily of structurally related protein families found throughout the tree of life. Actin-related proteins include chaperones, carbohydrate kinases, and other enzymes, as well as a staggeringly diverse set of proteins that use the energy from ATP hydrolysis to form dynamic, linear polymers. Despite differing widely from one another in filament structure and dynamics, these polymers play important roles in ordering cell space in bacteria, archaea, and eukaryotes. It is not known whether these polymers descended from a single ancestral polymer or arose multiple times by convergent evolution from monomeric actin-like proteins. In this work, we provide an overview of the structures, dynamics, and functions of this diverse set. Then, using a phylogenetic analysis to examine actin evolution, we show that the actin-related protein families that form polymers are more closely related to one another than they are to other nonpolymerizing members of the actin superfamily. Thus all the known actin-like polymers are likely to be the descendants of a single, ancestral, polymer-forming actin-like protein.

scholarly journals Plant dynamin-related protein families DRP1 and DRP2 in plant development

2010 ◽  
Vol 38 (3) ◽  
pp. 797-806 ◽  
Author(s):  
Sebastian Y. Bednarek ◽  
Steven K. Backues
Keyword(s):  
Plant Development ◽  
Membrane Trafficking ◽  
Cell Expansion ◽  
Cell Plate ◽  
Biological Knowledge ◽  
Related Protein ◽  
Protein Families ◽  
Cellular Processes ◽  
Domain Structures ◽  
Related Proteins

Two separate families of Arabidopsis dynamin-related proteins, DRP1 and DRP2, have been implicated in clathrin-mediated endocytosis and cell plate maturation during cytokinesis. The present review summarizes the current genetic, biochemical and cell biological knowledge about these two protein families, and suggests key directions for more fully understanding their roles and untangling their function in membrane trafficking. We focus particularly on comparing and contrasting these two protein families, which have very distinct domain structures and are independently essential for Arabidopsis development, yet which have been implicated in very similar cellular processes during cytokinesis and cell expansion.

scholarly journals Current Overview of Allergens of Plant Pathogenesis Related Protein Families

2014 ◽  
Vol 2014 ◽  
pp. 1-19 ◽  
Author(s):  
Mau Sinha ◽  
Rashmi Prabha Singh ◽  
Gajraj Singh Kushwaha ◽  
Naseer Iqbal ◽  
Avinash Singh ◽  
...  
Keyword(s):  
Amino Acid ◽  
Cross Reactivity ◽  
Amino Acid Sequences ◽  
Pr Proteins ◽  
Antigenic Determinants ◽  
Related Protein ◽  
Protein Families ◽  
Pathogenesis Related Protein ◽  
Pathogenesis Related ◽  
Plant Pathogenesis

Pathogenesis related (PR) proteins are one of the major sources of plant derived allergens. These proteins are induced by the plants as a defense response system in stress conditions like microbial and insect infections, wounding, exposure to harsh chemicals, and atmospheric conditions. However, some plant tissues that are more exposed to environmental conditions like UV irradiation and insect or fungal attacks express these proteins constitutively. These proteins are mostly resistant to proteases and most of them show considerable stability at low pH. Many of these plant pathogenesis related proteins are found to act as food allergens, latex allergens, and pollen allergens. Proteins having similar amino acid sequences among the members of PR proteins may be responsible for cross-reactivity among allergens from diverse plants. This review analyzes the different pathogenesis related protein families that have been reported as allergens. Proteins of these families have been characterized in regard to their biological functions, amino acid sequence, and cross-reactivity. The three-dimensional structures of some of these allergens have also been evaluated to elucidate the antigenic determinants of these molecules and to explain the cross-reactivity among the various allergens.

scholarly journals Clan CD of cysteine peptidases as an example of evolutionary divergences in related protein families across plant clades

Gene ◽  
2010 ◽  
Vol 449 (1-2) ◽  
pp. 59-69 ◽  
Author(s):  
Ines Cambra ◽  
Francisco J. Garcia ◽  
Manuel Martinez
Keyword(s):  
Related Protein ◽  
Protein Families ◽  
Cysteine Peptidases
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