The Use of Metal Ions as Spectroscopic Probes in the Elucidation of pKa’s of Small Molecules

1996 ◽  
pp. 71-80
Author(s):  
Bijan Farzami
Keyword(s):  
Metal Ions ◽  
Small Molecules ◽  
Spectroscopic Probes

scholarly journals Peptide-tags for site-specific protein labelling in vitro and in vivo

2016 ◽  
Vol 12 (6) ◽  
pp. 1731-1745 ◽  
Author(s):  
Jonathan Lotze ◽  
Ulrike Reinhardt ◽  
Oliver Seitz ◽  
Annette G. Beck-Sickinger
Keyword(s):  
Metal Ions ◽  
Small Molecules ◽  
Protein Localization ◽  
Specific Protein ◽  
Site Specific ◽  
Protein Labelling ◽  
Peptide Interactions ◽  
Peptide Tags

Peptide-tag based labelling can be achieved by (i) enzymes (ii) recognition of metal ions or small molecules and (iii) peptide–peptide interactions and enables site-specific protein visualization to investigate protein localization and trafficking.

A Robust Multifunctional Eu6-Cluster Based Framework for Gas Separation and Recognition of Small Molecules and Heavy Metal Ions

2019 ◽  
Vol 19 (11) ◽  
pp. 6381-6387 ◽  
Author(s):  
Falu Hu ◽  
Zhengyi Di ◽  
Mingyan Wu ◽  
Maochun Hong ◽  
Jing Li
Keyword(s):  
Heavy Metal ◽  
Metal Ions ◽  
Small Molecules ◽  
Gas Separation ◽  
Heavy Metal Ions

scholarly journals Carbon-based dots for electrochemiluminescence sensing

2020 ◽  
Vol 4 (2) ◽  
pp. 369-385 ◽  
Author(s):  
Ying Chen ◽  
Yue Cao ◽  
Cheng Ma ◽  
Jun-Jie Zhu
Keyword(s):  
Nucleic Acids ◽  
Metal Ions ◽  
Small Molecules ◽  
Analytical Approaches ◽  
Carbon Based

This review summarizes the recent development of ECL sensors based on carbon-based dots. Particularly, various analytical approaches involving metal ions, small molecules, proteins, nucleic acids and cells are thoroughly presented.

A flexible zwitterion ligand based lanthanide metal–organic framework for luminescence sensing of metal ions and small molecules

2015 ◽  
Vol 44 (24) ◽  
pp. 10914-10917 ◽  
Author(s):  
Rong-Mei Wen ◽  
Song-De Han ◽  
Guo-Jian Ren ◽  
Ze Chang ◽  
Yun-Wu Li ◽  
...  
Keyword(s):  
Metal Ions ◽  
Small Molecules ◽  
Metal Organic Framework ◽  
Metal Organic ◽  
Lanthanide Metal ◽  
Organic Framework

A new 3D luminescence LnMOF was synthesized using a tripodal flexible zwitterion ligand which takes a chair-shaped configuration. The compound displays highly selective luminescence sensing of the Fe3+ ion and nitrobenzene.

ChemInform Abstract: Biophysical Studies of the Amyloid β-Peptide: Interactions with Metal Ions and Small Molecules

ChemInform ◽  
2013 ◽  
Vol 44 (47) ◽  
pp. no-no
Author(s):  
Sebastian Waermlaender ◽  
Ann Tiiman ◽  
Axel Abelein ◽  
Jinghui Luo ◽  
Jyri Jarvet ◽  
...  
Keyword(s):  
Metal Ions ◽  
Small Molecules ◽  
Amyloid Β ◽  
Amyloid Β Peptide ◽  
Peptide Interactions ◽  
Biophysical Studies

Chemical Interactions in Ionomers and Ionomer Membranes Containing Metal particles and Ions

1999 ◽  
Vol 575 ◽  
Author(s):  
William M. Risen
Keyword(s):  
Fuel Cells ◽  
Metal Ions ◽  
Small Molecules ◽  
Distinct Species ◽  
Pem Fuel Cells ◽  
Metal Particles ◽  
Metal Carbonyls ◽  
Ionomer Membranes ◽  
Low Temperature Fuel Cells

ABSTRACTIonomer membranes are employed in PEM fuel cells as the proton conducting element, but they also hold potential for catalytic applications in both hydrogen based and other low temperature fuel cells. In these applications the reactions of H2, CO, 02, H20 and other small molecules with metal-based catalysts are important to consider. Reactions of these species with perfluorocarbonsulfonic acid based ionomers (PFSA), of which Nafionsa are prototypical, containing Rh, Ru, Pt and other metal ions and particles are shown. Metal carbonyls form with metal ions that have been reduced in situ to reduced valence ions or to metal particles, by the combination of CO and H2O or with H2 directly. Metal nitrogen complexes also can be formed. In addition, the interactions of dissimilar metal ions leads to distinct species with NO or CO, for example, that are different from the products with either ion separately.

scholarly journals Protein embeddings and deep learning predict binding residues for various ligand classes

2021 ◽  
Author(s):  
Maria Littmann ◽  
Michael Heinzinger ◽  
Christian Dallago ◽  
Konstantin Weissenow ◽  
Burkhard Rost
Keyword(s):  
Nucleic Acids ◽  
Metal Ions ◽  
Small Molecules ◽  
Protein Function ◽  
Language Model ◽  
Data Sets ◽  
Sequence Alignments ◽  
Multiple Sequence ◽  
Human Proteins ◽  
Binding Residues

AbstractOne important aspect of protein function is the binding of proteins to ligands, including small molecules, metal ions, and macromolecules such as DNA or RNA. Despite decades of experimental progress many binding sites remain obscure. Here, we proposed bindEmbed21, a method predicting whether a protein residue binds to metal ions, nucleic acids, or small molecules. The Artificial Intelligence (AI)-based method exclusively uses embeddings from the Transformer-based protein Language Model (pLM) ProtT5 as input. Using only single sequences without creating multiple sequence alignments (MSAs), bindEmbed21DL outperformed existing MSA-based methods. Combination with homology-based inference increased performance to F1=48±3% (95% CI) and MCC=0.46±0.04 when merging all three ligand classes into one. All results were confirmed by three independent data sets. Focusing on very reliably predicted residues could complement experimental evidence: For the 25% most strongly predicted binding residues, at least 73% were correctly predicted even when ignoring the problem of missing experimental annotations. The new method bindEmbed21 is fast, simple, and broadly applicable - neither using structure nor MSAs. Thereby, it found binding residues in over 42% of all human proteins not otherwise implied in binding and predicted about 6% of all residues as binding to metal ions, nucleic acids, or small molecules.

Pillared metal organic frameworks for the luminescence sensing of small molecules and metal ions in aqueous solutions

2015 ◽  
Vol 44 (4) ◽  
pp. 1754-1760 ◽  
Author(s):  
Fu-Hong Liu ◽  
Chao Qin ◽  
Yan Ding ◽  
Han Wu ◽  
Kui-Zhan Shao ◽  
...  
Keyword(s):  
Aqueous Solutions ◽  
Metal Ions ◽  
Small Molecules ◽  
Metal Organic Frameworks ◽  
Luminescent Probes ◽  
Highly Sensitive ◽  
Metal Organic

Two pillared-layer MOFs as luminescent probes with multifunctional sensitivities to detect metal ions and small molecules were reported. Our results show that the luminescence intensities of 1a and 2a are highly sensitive to Fe3+ and Cd2+ ions and small molecules such as acetone and nitrobenzene.

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