Oxygen Binding by the Metalloproteins Hemerythrin, Hemocyanin, and Hemoglobin

1988 ◽  
pp. 17-32 ◽  
Author(s):  
Thomas M. Loehr
Keyword(s):  
Oxygen Binding

Quaternary structure of Limulus polyphemus hemocyanin

1978 ◽  
Vol 36 (2) ◽  
pp. 176-177
Author(s):  
T. Wichertjes ◽  
E.J. Kwak ◽  
E.F.J. Van Bruggen
Keyword(s):  
Electron Microscopy ◽  
Functional Properties ◽  
Horseshoe Crab ◽  
Temperature Jump ◽  
Quaternary Structure ◽  
Crystallographic Analysis ◽  
Limulus Polyphemus ◽  
Oxygen Binding ◽  
X Ray ◽  
Intact Molecule

Hemocyanin of the horseshoe crab (Limulus polyphemus) has been studied in nany ways. Recently the structure, dissociation and reassembly was studied using electron microscopy of negatively stained specimens as the method of investigation. Crystallization of the protein proved to be possible and X-ray crystallographic analysis was started. Also fluorescence properties of the hemocyanin after dialysis against Tris-glycine buffer + 0.01 M EDTA pH 8.9 (so called “stripped” hemocyanin) and its fractions II and V were studied, as well as functional properties of the fractions by NMR. Finally the temperature-jump method was used for assaying the oxygen binding of the dissociating molecule and of preparations of isolated subunits. Nevertheless very little is known about the structure of the intact molecule. Schutter et al. suggested that the molecule possibly consists of two halves, combined in a staggered way, the halves themselves consisting of four subunits arranged in a square.

scholarly journals MWC allosteric model explains unusual hemoglobin oxygen binding curves from sickle cell drug binding

2021 ◽  
Author(s):  
E.R. Henry ◽  
J. Harper ◽  
K. Glass ◽  
B. Metaferia ◽  
J.M. Louis ◽  
...  
Keyword(s):  
Sickle Cell ◽  
Drug Binding ◽  
Oxygen Binding ◽  
Allosteric Model ◽  
Binding Curves

scholarly journals Probing the oxygen binding site of cytochrome c oxidase by cyanide.

1994 ◽  
Vol 269 (39) ◽  
pp. 24114-24119
Author(s):  
M.T. Wilson ◽  
G. Antonini ◽  
F. Malatesta ◽  
P. Sarti ◽  
M. Brunori
Keyword(s):  
Cytochrome C ◽  
Binding Site ◽  
Cytochrome C Oxidase ◽  
Oxygen Binding

Asymmetric Distribution of Cooperativity in the Binding Cascade of Normal Human Hemoglobin. 1. Cooperative and Noncooperative Oxygen Binding in Zn-Substituted Hemoglobin†

Biochemistry ◽  
2005 ◽  
Vol 44 (36) ◽  
pp. 11925-11938 ◽  
Author(s):  
Jo M. Holt ◽  
Alexandra L. Klinger ◽  
Connie S. Yarian ◽  
Varsha Keelara ◽  
Gary K. Ackers
Keyword(s):  
Asymmetric Distribution ◽  
Oxygen Binding ◽  
Human Hemoglobin ◽  
Normal Human

Blood–oxygen binding in healthy Standardbred horses

2005 ◽  
Vol 169 (2) ◽  
pp. 251-256 ◽  
Author(s):  
C. Cambier ◽  
N. Di Passio ◽  
T. Clerbaux ◽  
H. Amory ◽  
V. Marville ◽  
...  
Keyword(s):  
Oxygen Binding ◽  
Blood Oxygen

Oxygen-binding modulation of hemocyanin from the slipper lobster Scyllarides latus

2004 ◽  
Vol 139 (2) ◽  
pp. 261-268 ◽  
Author(s):  
Maria T. Sanna ◽  
Alessandra Olianas ◽  
Massimo Castagnola ◽  
Luigi Sollai ◽  
Barbara Manconi ◽  
...  
Keyword(s):  
Oxygen Binding

Effect of Age on Oxygen-Binding in Normal Human Subjects

1976 ◽  
Vol 51 (2) ◽  
pp. 185-188
Author(s):  
P. M. Tweeddale ◽  
R. J. E. Leggett ◽  
D. C. Flenley
Keyword(s):  
Oxygen Saturation ◽  
Oxygen Tension ◽  
Inorganic Phosphate ◽  
Human Subjects ◽  
Oxygen Binding ◽  
Corpuscular Haemoglobin ◽  
Positive Correlation ◽  
Normal Human ◽  
Mean Corpuscular Haemoglobin ◽  
Effect Of Age

1. Oxygen-binding, plasma and intra-erythrocytic pH, and haemoglobin, 2,3-diphosphoglycerate and inorganic phosphate concentrations were measured in sixty-two healthy non-smokers aged between 18 and 89 years. 2. P50 (oxygen tension at 50% oxygen saturation) expressed at plasma pH 7·40 and Pco2 5·33 kPa showed a positive correlation with age. 3. This correlation of P50 with age was closer when P50 was expressed at a constant intra-erythrocytic pH 7·20. On average P50 at intra-erythrocytic pH 7·20 increased from 3·59 kPa at 20 years to 3·96 kPa at 90 years of age. 4. 2,3-Diphosphoglycerate, inorganic phosphate, haemoglobin and mean corpuscular haemoglobin concentrations did not correlate with P50 or with age.

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