Aging-Related Pathology in Human Neuroblastoma and Teratocarcinoma Cell Lines

Author(s):  
Gregory M. Cole ◽  
Paola S. Timiras
1992 ◽  
Vol 3 (2-3) ◽  
pp. 139-150 ◽  
Author(s):  
Jacob S. Manaster ◽  
Tony Feuerman ◽  
C. Patrick Reynolds ◽  
Charles H. Markham

Cultured human catecholaminergic and noncatecholaminergic donor cells were used in neural transplantation experiments in a rat model of Parkinson's disease. Using two different human catecholaminergic neuroblastoma cell lines, one control non-catecholaminergic neuroblastoma cell line, and one sham control (tissue culture medium), transplants were made into the striatum using a modified Ungerstedt hemiparkinsonian rat model. Significant decreases in apomorphine-induced rotational behavior were produced by two of three catecholaminergic cell lines. Grafted cells staining positively for tyrosine hydroxylase (TH) and catecholamine fluorescence indicated viable catecholamine activity in the two cell lines which produced reductions in rotational behavior. Catecholamine fluorescence was not detected in either of the two controls. These data suggest a link between catecholamine secretion by transplanted cells and motor improvement using a rat rotational behavior model.


1985 ◽  
Vol 22 (6) ◽  
pp. 543-552 ◽  
Author(s):  
P. D�mant ◽  
M. Oudshoorn-Snoek

1986 ◽  
Vol 382 (2) ◽  
pp. 327-331 ◽  
Author(s):  
Günther Hochhaus ◽  
Victor C. Yu ◽  
Wolfgang Sadée

1995 ◽  
Vol 20 (6) ◽  
pp. 675-680 ◽  
Author(s):  
P. Rossino ◽  
G. Volpe ◽  
A. Negro ◽  
L. Callegaro ◽  
F. Altruda ◽  
...  

1997 ◽  
Vol 33 (12) ◽  
pp. 2007-2010 ◽  
Author(s):  
M.L Schmidt ◽  
K.L Kuzmanoff ◽  
L Ling-Indeck ◽  
J.M Pezzuto

1981 ◽  
Vol 1 (3) ◽  
pp. 301-312 ◽  
Author(s):  
Robert A. Ross ◽  
June L. Biedler ◽  
Barbara A. Spengler ◽  
Donald J. Reis

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