Circumvention of Neoplastic Heterogeneity by Systemically Activated Macrophages

1986 ◽  
pp. 311-322
Author(s):  
Isaiah J. Fidler ◽  
J. Milburn Jessup ◽  
Eugenie S. Kleinerman ◽  
William E. Fogler ◽  
Amitabha Mazumder
Keyword(s):  
Activated Macrophages

Reparação óssea no implante dental

2020 ◽  
Vol 12 (45) ◽  
pp. 63-66
Author(s):  
Halim Nagem Filho ◽  
Reinaldo Francisco Maia ◽  
Reinaldo Missaka ◽  
Nasser Hussein Fares
Keyword(s):  
Gene Expression ◽  
Titanium Surface ◽  
Close Contact ◽  
The Other ◽  
Main Function ◽  
Indirect Interaction ◽  
M2 Macrophages ◽  
Activated Macrophages ◽  
M1 Macrophages ◽  
High Production

The osseointegration is the stable and functional union between the bone and a titanium surface. A new bone can be found on the surface of the implant about 1 week after its installation; the bone remodeling begins between 6 and 12 weeks and continues throughout life. After the implant insertion, depending on the energy of the surface, the plasma fluid immediately adheres, in close contact with the surface, promoting the adsorption of proteins and inducing the indirect interaction of the cells with the material. Macrophages are cells found in the tissues and originated from bone marrow monocytes. The M1 macrophages orchestrate the phagocytic phase in the inflammatory region and also produce inflammatory cytokines involved with the chronic inflammation and the cleaning of the wound and damaged tissues from bacteria. On the other hand, alternative-activated macrophages (M2) are activated by IL-10, the immune complex. Its main function consists on regulating negatively the inflammation through the secretion of the immunosuppressant IL-10. The M2 macrophages present involvement with the immunosuppression, besides having a low capacity for presenting antigens and high production of cytokines; these can be further divided into M2a, M2b, and M2c, based on the gene expression profile.

scholarly journals Alternatively Activated Macrophages Are the Primary Retinoic Acid-Producing Cells in Human Decidua

2020 ◽  
Vol 27 (1) ◽  
pp. 334-341 ◽  
Author(s):  
Augustine Rajakumar ◽  
Maureen A. Kane ◽  
Jianshi Yu ◽  
Jace W. Jones ◽  
Hongyan Qu ◽  
...  
Keyword(s):  
Retinoic Acid ◽  
Activated Macrophages ◽  
Alternatively Activated Macrophages ◽  
Human Decidua ◽  
Alternatively Activated

Allergic airway disease is unaffected by the absence of IL-4Rα–dependent alternatively activated macrophages

2012 ◽  
Vol 130 (3) ◽  
pp. 743-750.e8 ◽  
Author(s):  
Natalie E. Nieuwenhuizen ◽  
Frank Kirstein ◽  
Jaisubash Jayakumar ◽  
Babele Emedi ◽  
Ramona Hurdayal ◽  
...  
Keyword(s):  
Airway Disease ◽  
Allergic Airway Disease ◽  
Activated Macrophages ◽  
Alternatively Activated Macrophages ◽  
Alternatively Activated
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