Effects of Nicotinic Acid and its Derivatives on Lipid Metabolism and Other Metabolic Factors Related to Atherosclerosis

1985 ◽  
pp. 281-293 ◽  
Author(s):  
Goeran Walldius ◽  
Gustaf Wahlberg
Keyword(s):  
Lipid Metabolism ◽  
Nicotinic Acid ◽  
Metabolic Factors

scholarly journals Effect of flavonoids morin; quercetin and nicotinic acid on lipid metabolism of rats experimentally fed with triton

2001 ◽  
Vol 44 (3) ◽  
pp. 263-267 ◽  
Author(s):  
Kelly Fabiane Santos Ricardo ◽  
Tânia Toledo de Oliveira ◽  
Tanus Jorge Nagem ◽  
Aloisio da Silva Pinto ◽  
Maria Goreti Almeida Oliveira ◽  
...  
Keyword(s):  
Body Weight ◽  
Lipid Metabolism ◽  
Nicotinic Acid ◽  
Blood Serum ◽  
Coronary Disease ◽  
Blood Circulation ◽  
Intraperitoneal Administration ◽  
Serum Levels ◽  
Flavonoid Compounds ◽  
Coronary Diseases

Atherosclerosis is a coronary disease where deposition of lipids in the arteries leads to problems of blood circulation. The present work evaluates the action of the flavonoids morin, quercetin and nicotinic acid isolated in association on lipid metabolism in hyperlipidemic rats. Blood serum levels cholesterol, cholesterol-HDL, and triacylglycerids have been analysed following the intraperitoneal administration of the flavonoid compounds dissolved in propyleneglycol by in doses of 5mg/kg body weight. Quercetin presented the largest percentual reduction of cholesterol. The best results for cholesterol-HDL have been obtained with-nicotinic acid alone while morin-nicotinic acid combination showed the best triacylglycerols results. Results showed that flavonoids could be beneficious in the treatment of coronary diseases.

scholarly journals COVID-19 induces new-onset insulin resistance and lipid metabolic dysregulation via regulation of secreted metabolic factors

2021 ◽  
Vol 6 (1) ◽  
Author(s):  
Xi He ◽  
Chenshu Liu ◽  
Jiangyun Peng ◽  
Zilun Li ◽  
Fang Li ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Lipid Metabolism ◽  
Isobutyric Acid ◽  
Transcriptional Level ◽  
Metabolic Factors ◽  
Metabolic Complications ◽  
Glucose And Lipid Metabolism ◽  
Metabolic Dysregulation ◽  
Underlying Mechanisms ◽  
New Onset

AbstractAbnormal glucose and lipid metabolism in COVID-19 patients were recently reported with unclear mechanism. In this study, we retrospectively investigated a cohort of COVID-19 patients without pre-existing metabolic-related diseases, and found new-onset insulin resistance, hyperglycemia, and decreased HDL-C in these patients. Mechanistically, SARS-CoV-2 infection increased the expression of RE1-silencing transcription factor (REST), which modulated the expression of secreted metabolic factors including myeloperoxidase, apelin, and myostatin at the transcriptional level, resulting in the perturbation of glucose and lipid metabolism. Furthermore, several lipids, including (±)5-HETE, (±)12-HETE, propionic acid, and isobutyric acid were identified as the potential biomarkers of COVID-19-induced metabolic dysregulation, especially in insulin resistance. Taken together, our study revealed insulin resistance as the direct cause of hyperglycemia upon COVID-19, and further illustrated the underlying mechanisms, providing potential therapeutic targets for COVID-19-induced metabolic complications.

Effects of etofibrate, clofibrate and nicotinic acid on lipid metabolism in normolipemic rats

1979 ◽  
Vol 10 (3) ◽  
pp. 215-219 ◽  
Author(s):  
J.G. Priego ◽  
M.L. Maroto ◽  
M. Piña ◽  
R.E. Catalan
Keyword(s):  
Lipid Metabolism ◽  
Nicotinic Acid

scholarly journals Nicotinic acid (NA) alters lipid metabolism in a pair‐fed mouse model

2008 ◽  
Vol 22 (S1) ◽  
Author(s):  
Amanda T White ◽  
John Menke ◽  
Mihajlo Krsmanovic ◽  
Larissa Wilsie ◽  
Andrew K P Taggart ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Mouse Model ◽  
Nicotinic Acid
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