scholarly journals Nicotinic acid (NA) alters lipid metabolism in a pair‐fed mouse model

2008 ◽  
Vol 22 (S1) ◽  
Author(s):  
Amanda T White ◽  
John Menke ◽  
Mihajlo Krsmanovic ◽  
Larissa Wilsie ◽  
Andrew K P Taggart ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Mouse Model ◽  
Nicotinic Acid

scholarly journals Lipid Metabolism Is Dysregulated before, during and after Pregnancy in a Mouse Model of Gestational Diabetes

2021 ◽  
Vol 22 (14) ◽  
pp. 7452
Author(s):  
Samuel Furse ◽  
Denise S. Fernandez-Twinn ◽  
Davide Chiarugi ◽  
Albert Koulman ◽  
Susan E. Ozanne
Keyword(s):  
Lipid Metabolism ◽  
Gestational Diabetes ◽  
Glucose Tolerance ◽  
Mouse Model ◽  
Time Course ◽  
De Novo ◽  
Lipid Analysis ◽  
Temporal Distribution ◽  
De Novo Lipogenesis ◽  
Analysis Tool

The aim of the current study was to test the hypothesis that maternal lipid metabolism was modulated during normal pregnancy and that these modulations are altered in gestational diabetes mellitus (GDM). We tested this hypothesis using an established mouse model of diet-induced obesity with pregnancy-associated loss of glucose tolerance and a novel lipid analysis tool, Lipid Traffic Analysis, that uses the temporal distribution of lipids to identify differences in the control of lipid metabolism through a time course. Our results suggest that the start of pregnancy is associated with several changes in lipid metabolism, including fewer variables associated with de novo lipogenesis and fewer PUFA-containing lipids in the circulation. Several of the changes in lipid metabolism in healthy pregnancies were less apparent or occurred later in dams who developed GDM. Some changes in maternal lipid metabolism in the obese-GDM group were so late as to only occur as the control dams’ systems began to switch back towards the non-pregnant state. These results demonstrate that lipid metabolism is modulated in healthy pregnancy and the timing of these changes is altered in GDM pregnancies. These findings raise important questions about how lipid metabolism contributes to changes in metabolism during healthy pregnancies. Furthermore, as alterations in the lipidome are present before the loss of glucose tolerance, they could contribute to the development of GDM mechanistically.

scholarly journals Effect of flavonoids morin; quercetin and nicotinic acid on lipid metabolism of rats experimentally fed with triton

2001 ◽  
Vol 44 (3) ◽  
pp. 263-267 ◽  
Author(s):  
Kelly Fabiane Santos Ricardo ◽  
Tânia Toledo de Oliveira ◽  
Tanus Jorge Nagem ◽  
Aloisio da Silva Pinto ◽  
Maria Goreti Almeida Oliveira ◽  
...  
Keyword(s):  
Body Weight ◽  
Lipid Metabolism ◽  
Nicotinic Acid ◽  
Blood Serum ◽  
Coronary Disease ◽  
Blood Circulation ◽  
Intraperitoneal Administration ◽  
Serum Levels ◽  
Flavonoid Compounds ◽  
Coronary Diseases

Atherosclerosis is a coronary disease where deposition of lipids in the arteries leads to problems of blood circulation. The present work evaluates the action of the flavonoids morin, quercetin and nicotinic acid isolated in association on lipid metabolism in hyperlipidemic rats. Blood serum levels cholesterol, cholesterol-HDL, and triacylglycerids have been analysed following the intraperitoneal administration of the flavonoid compounds dissolved in propyleneglycol by in doses of 5mg/kg body weight. Quercetin presented the largest percentual reduction of cholesterol. The best results for cholesterol-HDL have been obtained with-nicotinic acid alone while morin-nicotinic acid combination showed the best triacylglycerols results. Results showed that flavonoids could be beneficious in the treatment of coronary diseases.

scholarly journals P.068 Abnormal fatty acid metabolism is a feature of spinal muscular atrophy

2019 ◽  
Vol 46 (s1) ◽  
pp. S32
Author(s):  
M Deguise ◽  
A Beauvais ◽  
G Baranello ◽  
C Pileggi ◽  
C Mastella ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Lipid Metabolism ◽  
High Resolution ◽  
Mouse Model ◽  
Spinal Muscular Atrophy ◽  
Muscular Atrophy ◽  
Liver Steatosis ◽  
Neuromuscular Disorder ◽  
Glycogen Depletion ◽  
Preclinical Animal Models

Background: Spinal muscular atrophy (SMA) is a children’s neuromuscular disorder. Although motor neuron loss is a major feature of the disease, we have identified fatty acid abnormalities in SMA patients and in preclinical animal models, suggesting metabolic perturbation is also an important component of SMA. Methods: Biochemical, histological, proteomic, and high resolution respirometry were used. Results: SMA patients are more susceptible to dyslipidemia than the average population as determined by a standard lipid profile in a cohort of 72 pediatric patients. As well, we observed a non-alcoholic liver disease phenotype in apreclinical mouse model. Denervation alone was not sufficient to induce liver steatosis, as a mouse model of ALS, did not develop fatty liver. Hyperglucagonemia in Smn2B/-mice could explain the hepatic steatosis by increasing plasma substrate availability via glycogen depletion and peripheral lipolysis. Proteomic analysis identified mitochondrion and lipid metabolism as major clusters. Alterations in mitochondrial function were revealed by high-resolution respirometry. Finally, low-fat diets led to increased survival in Smn2B/-mice. Conclusions: These results provide strong evidence for lipid metabolism defects in SMA. Further investigation will be required to establish the primary mechanism of these alterations and understand how they lead to additional co-morbidities in SMA patients.

Metabolomics Reveals Altered Lipid Metabolism in a Mouse Model of Endometriosis

2016 ◽  
Vol 15 (8) ◽  
pp. 2626-2633 ◽  
Author(s):  
Mainak Dutta ◽  
Mallappa Anitha ◽  
Philip B. Smith ◽  
Christopher R. Chiaro ◽  
Meenu Maan ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Mouse Model ◽  
Altered Lipid Metabolism ◽  
Altered Lipid

scholarly journals Study of Phenytoin Effect on the genes involved in glucose and lipid metabolism expression in liver: A mouse model study

2021 ◽  
Vol 2 (2) ◽  
pp. 62-68
Author(s):  
Fatemeh Samimi ◽  
Ali Mohammad Ahadi ◽  
Nafiseh Boroomand ◽  
Farzaneh Mohammadzadeh Rostami
Keyword(s):  
Lipid Metabolism ◽  
Mouse Model ◽  
Glucose And Lipid Metabolism ◽  
Model Study

Crosstalk between gut microbiota and host lipid metabolism in a mouse model of alcoholic liver injury by chronic baijiu or ethanol feeding

2022 ◽  
Author(s):  
Cheng Fang ◽  
Qingwu Zhou ◽  
Qingyang Liu ◽  
Wei Jia ◽  
Yan Xu
Keyword(s):  
Lipid Metabolism ◽  
Liver Injury ◽  
Mouse Model ◽  
Gut Microbiota ◽  
Alcoholic Beverage ◽  
Alcoholic Liver Injury ◽  
Ethanol Feeding

This study demonstrates that compounds in baijiu, a traditional Chinese alcoholic beverage, can attenuate the development of ethanol-induced liver injury by regulating the crosstalk between gut microbiota and host lipid metabolism.

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