Studies on the Measurement of α-Methyldopa in Pregnant Women and the Newborn Infant

EXCRETION OF 15α-HYDROXYOESTRIOL AND OESTRIOL IN URINE OF NEWBORN INFANTS AND IN MATERNAL URINE BEFORE AND AFTER DELIVERY

Journal of Endocrinology ◽

10.1677/joe.0.0520119 ◽

1972 ◽

Vol 52 (1) ◽

pp. 119-128 ◽

Cited By ~ 5

Author(s):

JORMA HEIKKILÄ

Keyword(s):

Pregnant Women ◽

Linear Function ◽

Newborn Infant ◽

Newborn Infants ◽

Urine Samples ◽

Maternal Urine ◽

Before And After

SUMMARY The amounts of oestriol and 15α-hydroxyoestriol (oestetrol) were determined in 24-h urine samples collected from pregnant women before and after delivery. In addition, the concentrations of these oestrogens were estimated in the urine of the newborn infants born to these mothers. The excretion of both these oestrogens decreased exponentially in maternal urine after delivery, the rate of decrease being significantly slower for oestetrol. The concentration of oestriol and oestetrol in the urine of the newborn infants also fell rapidly after delivery, the reduction being a linear function of time. The concentration of oestetrol in the urine of the newborn infant was relatively high in comparison to that of oestriol, and during the first day of life was the same as in maternal urine before delivery.

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Perinatal infections in the Russian Federation. Screening strategies: problems and prospectives

Journal of obstetrics and women s diseases ◽

10.17816/jowd62370-76 ◽

2013 ◽

Vol 62 (3) ◽

pp. 70-76

Author(s):

Alevtina M Savicheva

Keyword(s):

Adverse Effects ◽

Infectious Diseases ◽

Pregnant Women ◽

Newborn Infant ◽

Russian Federation ◽

Early Pregnancy ◽

Pregnancy Planning ◽

Screening Strategies ◽

The Russian Federation ◽

Prevention Of Infections

The article describes principal problems of the diagnosis and prevention of perinatal infections in the Russian Federation. Data on the prevalence of infectious diseases in pregnant women, the ways of transmission of infection from mother to fetus and newborn infant, as well as adverse effects are discussed. Possible ways of solving the current problems are suggested, such as the development of standards and algorithms of diagnosis and prevention of infections during pregnancy planning and early pregnancy terms.

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HYPERBILIRUBINEMIA OF NEWBORN INFANTS ASSOCIATED WITH THE PARENTERAL ADMINISTRATION OF A VITAMIN K ANALOGUE TO THE MOTHERS

PEDIATRICS ◽

10.1542/peds.23.3.553 ◽

1959 ◽

Vol 23 (3) ◽

pp. 553-560

Author(s):

Jerold F. Lucey ◽

Robert G. Dolan

Keyword(s):

Pregnant Women ◽

Newborn Infant ◽

Premature Infants ◽

Vitamin K ◽

Newborn Infants ◽

New Drugs ◽

Parenteral Administration ◽

Prophylactic Effect ◽

Hepatotoxic Effect

Seven cases of marked hyperbilirubinemia occurring among premature infants within the first 40 to 72 hours of life are reported. The mothers of these infants had received 72 mg of a vitamin K analogue (Hykinone®) intramuscularly or intravencusly from 2 to 112 hours prior to delivery. The evidence presented indicates that this medication predisposed the infants to hyperbilirubinemia. The hypothesis is presented that the vitamin K analogue passed through the placenta and exerted a hepatotoxic effect upon the newborn infant. Because of possible serious consequences to the infant, new drugs should be used with caution when administered to pregnant women or to newborn infants, and medications should be given in doses no larger than necessary to obtain a desired and proven therapeutic or prophylactic effect.

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Infections in mother, fetus and newborn infant

Pediatrician (St Petersburg) ◽

10.17816/ped533-8 ◽

2014 ◽

Vol 5 (3) ◽

pp. 3-8

Author(s):

Alevtina Mikhailovna Savicheva

Keyword(s):

Adverse Effects ◽

Pregnant Women ◽

Newborn Infant ◽

National Guidelines

The article reviews some major problems of diagnosis, prophylaxis and treatment of infections in mother, fetus and newborn infant and discusses possible ways of solving them. It is emphasized that there is a need in standardized approaches to management of pregnant women with infections imposing a risk of adverse effects on fetus or newborn infant, which can be achieved by development and implementation of national guidelines on management of perinatal infections.

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