Lymphoid Tissue Architecture. III. Germinal Centers, T Cells, and Thymus-Dependent vs Thymus-Independent Antigens

1976 ◽  
pp. 229-237 ◽  
Author(s):  
I. L. Weissman ◽  
G. A. Gutman ◽  
S. H. Friedberg ◽  
L. Jerabek
Keyword(s):  
T Cells ◽  
Lymphoid Tissue ◽  
Germinal Centers ◽  
Tissue Architecture

scholarly journals Effects of Colonization of Gnotobiotic Swiss Webster Mice with Helicobacter bilis

2020 ◽  
Vol 70 (3) ◽  
pp. 216-232
Author(s):  
Mark T Whary ◽  
Chuanwu Wang ◽  
Catherine F Ruff ◽  
Mallory J DiVincenzo ◽  
Caralyn Labriola ◽  
...  
Keyword(s):  
T Cells ◽  
Mhc Class Ii ◽  
Lymphoid Tissue ◽  
Inbred Mice ◽  
Germinal Centers ◽  
Tertiary Lymphoid Tissue ◽  
Lower Bowel ◽  
Helicobacter Bilis ◽  
Class Ii Antigen ◽  
Mhc Class Ii Antigen

Helicobacter bilis (Hb) causes hepatitis in some strains of inbred mice. The current study confirmed that Hb directly causes portal hepatitis in outbred gnotobiotic Swiss Webster (SW) mice, as we previously reported for conventional SW mice. Hbmonoassociated SW mice also developed mild enterocolitis, expanded gut-associated lymphoid tissue (GALT), and tertiary lymphoid tissue in the lower bowel. At 1 and 10 mo after infection, Hb-induced GALT hyperplasia exhibited well-organized, ectopic germinal centers with increased mononuclear cell apoptosis, MHC class II antigen presentation, and pronounced endothelial venule formation, consistent with features of tertiary lymphoid tissue. In the lower bowel, Hb induced mainly B220+ cells as well as CD4+ IL17+, CD4+ IFNγ+, and CD4+ FoxP3+ regulatory T cells and significantly increased IL10 mRNA expression. This gnotobiotic model confirmed that Hb causes portal hepatitis in outbred SW mice but stimulated GALT with an antiinflammatory bias. Because Hb had both anti- and proinflammatory effects on GALT, it should be considered a 'pathosymbiont provocateur' and merits further evaluation in mouse models of human disease.

The Biology of Germinal Centers in Lymphoid Tissue

1998 ◽  
Author(s):  
G. Jeanette Thorbecke ◽  
Vincent K. Tsiagbe
Keyword(s):  
Lymphoid Tissue ◽  
Germinal Centers

scholarly journals Cell-to-Cell Transmission of HIV-1 Is Required to Trigger Pyroptotic Death of Lymphoid-Tissue-Derived CD4 T Cells

Cell Reports ◽  
2015 ◽  
Vol 12 (10) ◽  
pp. 1555-1563 ◽  
Author(s):  
Nicole L.K. Galloway ◽  
Gilad Doitsh ◽  
Kathryn M. Monroe ◽  
Zhiyuan Yang ◽  
Isa Muñoz-Arias ◽  
...  
Keyword(s):  
T Cells ◽  
Cd4 T Cells ◽  
Lymphoid Tissue ◽  
Cell Transmission ◽  
Hiv 1

scholarly journals Acquisition of Pneumococci Specific Effector and Regulatory Cd4+ T Cells Localising within Human Upper Respiratory-Tract Mucosal Lymphoid Tissue

2011 ◽  
Vol 7 (12) ◽  
pp. e1002396 ◽  
Author(s):  
Jeffrey Pido-Lopez ◽  
William W. Kwok ◽  
Timothy J. Mitchell ◽  
Robert S. Heyderman ◽  
Neil A. Williams
Keyword(s):  
T Cells ◽  
Respiratory Tract ◽  
Cd4 T Cells ◽  
Lymphoid Tissue ◽  
Upper Respiratory Tract ◽  
Specific Effector ◽  
Upper Respiratory ◽  
Mucosal Lymphoid Tissue

PD-1 blockade and vaccination provide therapeutic benefit against SIV by inducing broad and functional CD8 + T cells in lymphoid tissue

2021 ◽  
Vol 6 (63) ◽  
Author(s):  
Sheikh Abdul Rahman ◽  
Bhrugu Yagnik ◽  
Alexander P. Bally ◽  
Kristen N. Morrow ◽  
Shelly Wang ◽  
...  
Keyword(s):  
T Cells ◽  
Cd8 T Cells ◽  
Lymphoid Tissue ◽  
Therapeutic Benefit

Functional zones of Peyer’s patch (PPs) in rabbits’ caecum

2021 ◽  
Vol 9 (2) ◽  
pp. 82-86
Author(s):  
M. O. Nikitina ◽  
M. V. Kravtsova ◽  
A. A. Bohomaz
Keyword(s):  
Germinal Center ◽  
Lymphoid Tissue ◽  
Experimental Period ◽  
Vermiform Appendix ◽  
Mean Value ◽  
Germinal Centers ◽  
Peyer's Patches ◽  
Peyer’S Patches ◽  
Mantle Zone ◽  
Lymphoid Nodules

A feature of rabbit gut-associated lymphoid tissue is that its structure is more developed than in other animal species. In rabbits it is composed of sacculus rotundus, vermiform appendix and Peyer’s patches. These immune formations contain an organized component of lymphoid tissue – lymphoid nodules (B-cell zone) and interfollicular region (T-cell). Secondary lymphoid nodules with germinal centers presented in them are formed due to antigen stimulation. The caecum of Hyplus rabbits at the age of 30 -, 60 - and 90-days was investigated. Each age group consisted of 5 rabbits. Experimental rabbits are clinically healthy, unvaccinated and untreated against ecto- and endoparasites. Peyer’s patches of the caecum were selected for the study and fixed in 10% of formalin. Subsequently, the specimens stained with hematoxylin-eosin were prepared from the obtained samples. On the 30th day of life, Peyer’s patches in the cecum were detected by gross examination. On the histological level, they had formed interfollicular region and lymphoid nodules. In turn, lymphoid nodules were divided into primary and secondary ones. A well-defined mantle zone and germinal centers were observed in the secondary lymphoid nodules. The regularities of their area indicators increase (mean value, median and interquartile range (IQR)) and their correlation were studied. The most intensive growth of the mantle area and the germinal center was observed from the 30th to the 60th day. The relative area of the mantle zone and the germinal center as part of the secondary lymphoid nodule was determined. Its value did not change during the experimental period.

scholarly journals CD8 T cells primed in the gut-associated lymphoid tissue induce immune-mediated cholangitis in mice

Hepatology ◽  
2013 ◽  
Vol 59 (2) ◽  
pp. 601-611 ◽  
Author(s):  
Daniel Seidel ◽  
Ira Eickmeier ◽  
Anja A. Kühl ◽  
Alf Hamann ◽  
Christoph Loddenkemper ◽  
...  
Keyword(s):  
T Cells ◽  
Cd8 T Cells ◽  
Lymphoid Tissue ◽  
Immune Mediated

scholarly journals Curcumin improves regulatory T cells in gut-associated lymphoid tissue of colitis mice

2016 ◽  
Vol 22 (23) ◽  
pp. 5374 ◽  
Author(s):  
Hai-Mei Zhao ◽  
Rong Xu ◽  
Xiao-Ying Huang ◽  
Shao-Min Cheng ◽  
Min-Fang Huang ◽  
...  
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Lymphoid Tissue

scholarly journals Follicular T cells are clonally and transcriptionally distinct in B cell-driven mouse autoimmune disease

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Elliot H. Akama-Garren ◽  
Theo van den Broek ◽  
Lea Simoni ◽  
Carlos Castrillon ◽  
Cees E. van der Poel ◽  
...  
Keyword(s):  
T Cells ◽  
Autoimmune Disease ◽  
B Cell ◽  
Single Cell ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
Germinal Centers ◽  
Learning Approaches ◽  
Differential Gene ◽  
Disease Antigen

AbstractPathogenic autoantibodies contribute to tissue damage and clinical decline in autoimmune disease. Follicular T cells are central regulators of germinal centers, although their contribution to autoantibody-mediated disease remains unclear. Here we perform single cell RNA and T cell receptor (TCR) sequencing of follicular T cells in a mouse model of autoantibody-mediated disease, allowing for analyses of paired transcriptomes and unbiased TCRαβ repertoires at single cell resolution. A minority of clonotypes are preferentially shared amongst autoimmune follicular T cells and clonotypic expansion is associated with differential gene signatures in autoimmune disease. Antigen prediction using algorithmic and machine learning approaches indicates convergence towards shared specificities between non-autoimmune and autoimmune follicular T cells. However, differential autoimmune transcriptional signatures are preserved even amongst follicular T cells with shared predicted specificities. These results demonstrate that follicular T cells are phenotypically distinct in B cell-driven autoimmune disease, providing potential therapeutic targets to modulate autoantibody development.

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