Looking Within the Zebrafish to Understand the Tuberculous Granuloma

2013 ◽  
pp. 251-266 ◽  
Author(s):  
Lalita Ramakrishnan
Keyword(s):  
Tuberculous Granuloma

A non-canonical type 2 immune response coordinates tuberculous granuloma formation and epithelialization

Cell ◽  
2021 ◽  
Author(s):  
Mark R. Cronan ◽  
Erika J. Hughes ◽  
W. Jared Brewer ◽  
Gopinath Viswanathan ◽  
Emily G. Hunt ◽  
...  
Keyword(s):  
Immune Response ◽  
Granuloma Formation ◽  
Type 2 Immune Response ◽  
Tuberculous Granuloma ◽  
Canonical Type

scholarly journals A Case of Oculomotor Nerve Palsy and Choroidal Tuberculous Granuloma Associated with Tuberculous Meningoencephalitis

2008 ◽  
Vol 22 (3) ◽  
pp. 201 ◽  
Author(s):  
Sunghyuk Moon ◽  
Junhyuk Son ◽  
Woohyok Chang
Keyword(s):  
Nerve Palsy ◽  
Oculomotor Nerve ◽  
Oculomotor Nerve Palsy ◽  
Tuberculous Granuloma

IV bolus CT findings of the tuberculous granuloma: A case report

1993 ◽  
Vol 29 (1) ◽  
pp. 147
Author(s):  
Jae Ho Cho ◽  
Jae Chun Jang ◽  
Bok Hwan Park
Keyword(s):  
Case Report ◽  
Ct Findings ◽  
Tuberculous Granuloma

The lung microbiome, vitamin D, and the tuberculous granuloma: A balance triangle

2019 ◽  
Vol 131 ◽  
pp. 158-163 ◽  
Author(s):  
María Elvira Balcells ◽  
Noemí Yokobori ◽  
Bo-young Hong ◽  
John Corbett ◽  
Jorge Cervantes
Keyword(s):  
Vitamin D ◽  
Lung Microbiome ◽  
Tuberculous Granuloma

A non-tuberculous granuloma in cats

1962 ◽  
Vol 10 (1) ◽  
pp. 7-9 ◽  
Author(s):  
Lloyd R. Brown ◽  
Clinton D. May ◽  
Stephen E. Williams
Keyword(s):  
Tuberculous Granuloma

Sterile Tuberculous Granuloma In a Patient with XDR-TB Treated with Bedaquiline, Pretomanid and Linezolid

2019 ◽  
Author(s):  
P.J.B. Howell ◽  
C. Upton ◽  
N. Mvuna ◽  
C. van Niekerk ◽  
D. Everitt ◽  
...  
Keyword(s):  
Tuberculous Granuloma

An immunomodulatory role for the Mycobacterium tuberculosis Acr protein in the formation of the tuberculous granuloma

FEBS Letters ◽  
2020 ◽  
Author(s):  
Eamonn F. Healy ◽  
Lisa M. Goering ◽  
Charles R. Hauser ◽  
Peter J. King
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Tuberculous Granuloma

Development of an in vitro model of the early-stage bovine tuberculous granuloma using Mycobacterium bovis-BCG

2015 ◽  
Vol 168 (3-4) ◽  
pp. 249-257 ◽  
Author(s):  
Laura Garza-Cuartero ◽  
Elaine McCarthy ◽  
Joseph Brady ◽  
Joseph Cassidy ◽  
Clare Hamilton ◽  
...  
Keyword(s):  
Mycobacterium Bovis ◽  
In Vitro Model ◽  
Early Stage ◽  
Mycobacterium Bovis Bcg ◽  
Tuberculous Granuloma ◽  
Vitro Model

scholarly journals Clinical Significance of M1/M2 Macrophages and Related Cytokines in Patients with Spinal Tuberculosis

2020 ◽  
Vol 2020 ◽  
pp. 1-8
Author(s):  
Liang Wang ◽  
Xiaoqian Shang ◽  
Xinwei Qi ◽  
Derong Ba ◽  
Jie Lv ◽  
...  
Keyword(s):  
Macrophage Polarization ◽  
Spinal Tuberculosis ◽  
Giant Cells ◽  
Interleukin 10 ◽  
Enzyme Linked Immunosorbent Assay ◽  
Healthy Controls ◽  
M2 Macrophages ◽  
Rt Pcr ◽  
Tuberculous Granuloma ◽  
Anti Inflammatory

Background. Macrophages are important immune cells involved in Mycobacterium tuberculosis (M.tb) infection. To further investigate the degree of disease development in patients with spinal tuberculosis (TB), we conducted research on macrophage polarization. Methods. Thirty-six patients with spinal TB and twenty-five healthy controls were enrolled in this study. The specific morphology of tuberculous granuloma in spinal tissue was observed by hematoxylin-eosin (H&E) staining. The presence and distribution of bacilli were observed by Ziehl-Neelsen (ZN) staining. Macrophage-specific molecule CD68 was detected by immunohistochemistry (IHC). M1 macrophages play a proinflammatory role, including the specific molecule nitric oxide synthase (iNOS) and the related cytokine tumor necrosis factor-α (TNF-α) and interferon-γ (IFN-γ). M2 macrophages exert anti-inflammatory effects, including the specific molecule CD163 and related cytokine interleukin-10 (IL-10). The above markers were all detected by quantitative real-time PCR (RT-PCR), enzyme-linked immunosorbent assay (ELISA), and IHC. Results. Typical tuberculous granuloma was observed in the HE staining of patients with spinal TB. ZN staining showed positive expression of Ag85B around the caseous necrosis tissue and Langerhans multinucleated giant cells. At the same time, IHC results indicated that CD68, iNOS, CD163, IL-10, TNF-α, and IFN-γ were expressed around the tuberculous granuloma, and their levels were obviously higher in close tissue than in the distant tissue. RT-PCR and ELISA results indicated that IL-10, TNF-α, and IFN-γ levels of TB patients were also higher than those of the healthy controls. Conclusion. The report here highlights that two types of macrophage polarization (M1 and M2) are present in the tissues and peripheral blood of patients with spinal TB. Macrophages also play proinflammatory and anti-inflammatory roles. Macrophage polarization is involved in spinal TB infection.

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