Immunization Strategies Against Pulmonary Tuberculosis: Considerations of T Cell Geography

2013 ◽  
pp. 267-278 ◽  
Author(s):  
Carly N. Horvath ◽  
Zhou Xing
Keyword(s):  
T Cell ◽  
Pulmonary Tuberculosis ◽  
Immunization Strategies

Modulatory effect of Tim-3/Galectin-9 axis on T-cell-mediated immunity in pulmonary tuberculosis

2020 ◽  
Vol 45 (1) ◽  
Author(s):  
Jing Kang ◽  
Zhi-Feng Wei ◽  
Ming-Xian Li ◽  
Jing-Hua Wang
Keyword(s):  
T Cell ◽  
Pulmonary Tuberculosis ◽  
Cell Mediated Immunity

Modulation of T cell cytokine production by miR-144* with elevated expression in patients with pulmonary tuberculosis

2011 ◽  
Vol 48 (9-10) ◽  
pp. 1084-1090 ◽  
Author(s):  
Yanhua Liu ◽  
Xinjing Wang ◽  
Jing Jiang ◽  
Zhihong Cao ◽  
Bingfen Yang ◽  
...  
Keyword(s):  
T Cell ◽  
Pulmonary Tuberculosis ◽  
Cytokine Production ◽  
Elevated Expression ◽  
Cell Cytokine Production

scholarly journals Low occurrence of arthritic manifestations in patients with pulmonary tuberculosis: T cell subsets and humoral studies

1995 ◽  
Vol 90 (5) ◽  
pp. 623-628 ◽  
Author(s):  
Diana Dlugovitzky ◽  
Ariel Torres ◽  
María C. Hourquescos ◽  
María J. Svetaz ◽  
Norberto Quagliato ◽  
...  
Keyword(s):  
T Cell ◽  
Pulmonary Tuberculosis ◽  
T Cell Subsets

scholarly journals Peripheral T Cell Subpopulation in Patients with Pulmonary Tuberculosis

1984 ◽  
Vol 31 (4) ◽  
pp. 171-175
Author(s):  
Mi Wan Lee ◽  
Jeong Ha Chae ◽  
Hwa Sik Moon ◽  
Jung Sup Song ◽  
Jae Cheol Ro ◽  
...  
Keyword(s):  
T Cell ◽  
Pulmonary Tuberculosis ◽  
Cell Subpopulation

scholarly journals The T cell receptor subsets of lymphocytes in bronchoalveolar lavage in patients with active pulmonary tuberculosis

1998 ◽  
Vol 92 (3) ◽  
pp. 408-414 ◽  
Author(s):  
S-T. Uh ◽  
S.Y. Ki ◽  
G-I. Lim ◽  
S.H. Moon ◽  
S.W. Jeong ◽  
...  
Keyword(s):  
T Cell ◽  
Pulmonary Tuberculosis ◽  
Bronchoalveolar Lavage ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
Active Pulmonary Tuberculosis

scholarly journals Mycobacterium bovis BCG Scar Status and HLA Class II Alleles Influence Purified Protein Derivative-Specific T-Cell Receptor Vβ Expression in Pulmonary Tuberculosis Patients from Southern India

2003 ◽  
Vol 71 (8) ◽  
pp. 4544-4553 ◽  
Author(s):  
S. Shanmugalakshmi ◽  
V. Dheenadhayalan ◽  
P. Muthuveeralakshmi ◽  
G. Arivarignan ◽  
R.M. Pitchappan
Keyword(s):  
T Cell ◽  
Pulmonary Tuberculosis ◽  
T Cell Receptor ◽  
Mycobacterium Bovis ◽  
Cell Receptor ◽  
Hla Class Ii ◽  
Southern India ◽  
Specific Expression ◽  
Tuberculosis Patients ◽  
Purified Protein Derivative

ABSTRACT Purified protein derivative (PPD) RT23-recalled T-cell receptor (TCR) Vβ expression was studied in the peripheral blood of 42 pulmonary tuberculosis patients and 44 healthy controls from southern India, a region where tuberculosis is endemic. Forty-eight-hour whole-blood cultures in the presence or absence of PPD-RT23 were set up, and at the end of the culture period total RNA was extracted and cDNA was synthesized. Expression of various TCR Vβ families was assessed by using family-specific primers. PPD-specific expression (usage) of TCR Vβ families 4, 6, 8 to 12, and 14 was found in more controls than patients. Among the responders (individuals who showed PPD-specific expression), endemic controls had significantly higher responses than the patients had for TCR Vβ families 2, 3, 7, 13, and 17. The majority of the patients did not show usage of most of the TCR Vβ families, and this was attributed to T-cell downregulation. A four-way nested classification analysis revealed that TCR Vβ family 1, 5, 9, 12, and 13 usage in the context of HLA class II high-risk alleles (DRB1*1501, DRB1*08, and DQB1*0601) and Mycobacterium bovis BCG scar status were the determining factors in susceptibility and resistance to tuberculosis. The healthier status of controls was attributed to the wider usage of many TCR Vβ families readily recalled by PPD, while the disease status of the patients was attributed to TCR Vβ downregulation and the resultant T-cell (memory cell?) unresponsiveness. Host genetics (HLA status) and BCG vaccination (scar status) seem to play important roles in skewing the immune response in adult susceptibility to pulmonary tuberculosis through TCR Vβ usage.

scholarly journals Role of B Cells in Mucosal Vaccine–Induced Protective CD8+ T Cell Immunity against Pulmonary Tuberculosis

2015 ◽  
Vol 195 (6) ◽  
pp. 2900-2907 ◽  
Author(s):  
Amandeep K. Khera ◽  
Sam Afkhami ◽  
Rocky Lai ◽  
Mangalakumari Jeyanathan ◽  
Anna Zganiacz ◽  
...  
Keyword(s):  
T Cell ◽  
B Cells ◽  
Pulmonary Tuberculosis ◽  
Cd8 T Cell ◽  
T Cell Immunity ◽  
Mucosal Vaccine ◽  
Cell Immunity

scholarly journals The role of candidate miRNAs in T Cell response during acute pulmonary tuberculosis in Kumasi, Ghana

2014 ◽  
Vol 21 ◽  
pp. 308
Author(s):  
A. Afum-Adjei Awuah ◽  
B. Ueberberg ◽  
E. Owusu-Dabo ◽  
M. Jacobson
Keyword(s):  
T Cell ◽  
Pulmonary Tuberculosis ◽  
Cell Response ◽  
T Cell Response ◽  
Candidate Mirnas

scholarly journals Mixed Th1 and Th2 Mycobacterium tuberculosis-specific CD4 T cell responses in patients with active pulmonary tuberculosis from Tanzania

2017 ◽  
Vol 11 (7) ◽  
pp. e0005817 ◽  
Author(s):  
Patrizia Amelio ◽  
Damien Portevin ◽  
Klaus Reither ◽  
Francis Mhimbira ◽  
Maxmillian Mpina ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
T Cell ◽  
Pulmonary Tuberculosis ◽  
T Cell Responses ◽  
Cd4 T Cell ◽  
Active Pulmonary Tuberculosis ◽  
Cell Responses ◽  
Th1 And Th2
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