Membrane Transporters in ADME

2013 ◽  
pp. 1-22
Author(s):  
Bente Steffansen ◽  
Carsten Uhd Nielsen ◽  
Birger Brodin
Keyword(s):  
Membrane Transporters

Targeting Membrane Transporters and Receptors as a mean to Optimize Orally Delivered Biotechnological based Drugs through Nanoparticle Delivery Systems

2014 ◽  
Vol 15 (7) ◽  
pp. 650-658 ◽  
Author(s):  
Carla Pereira ◽  
Francisca Araujo ◽  
Pedro Granja ◽  
Helder Santos ◽  
Bruno Sarmento
Keyword(s):  
Delivery Systems ◽  
Membrane Transporters ◽  
Nanoparticle Delivery

scholarly journals Herbal Products and Their Active Constituents Used Alone and in Combination with Antifungal Drugs against Drug-Resistant Candida sp.

Antibiotics ◽  
2021 ◽  
Vol 10 (6) ◽  
pp. 655
Author(s):  
Anna Herman ◽  
Andrzej Przemysław Herman
Keyword(s):  
Biofilm Formation ◽  
Fungal Infections ◽  
Antifungal Drugs ◽  
Membrane Transporters ◽  
Drug Resistant ◽  
Herbal Products ◽  
Active Constituents ◽  
Over Expression ◽  
Candida Sp ◽  
Current State

Clinical isolates of Candida yeast are the most common cause of opportunistic fungal infections resistant to certain antifungal drugs. Therefore, it is necessary to detect more effective antifungal agents that would be successful in overcoming such infections. Among them are some herbal products and their active constituents.The purpose of this review is to summarize the current state of knowledge onherbal products and their active constituents havingantifungal activity against drug-resistant Candida sp. used alone and in combination with antifungal drugs.The possible mechanisms of their action on drug-resistant Candida sp. including (1) inhibition of budding yeast transformation into hyphae; (2) inhibition of biofilm formation; (3) inhibition of cell wall or cytoplasmic membrane biosynthesis; (4) ROS production; and (5) over-expression of membrane transporters will be also described.

scholarly journals Sulpiride Serves, a Substrate for the Gut Microbiome

Dose-Response ◽  
2021 ◽  
Vol 19 (1) ◽  
pp. 155932582098794
Author(s):  
Imran Mukhtar ◽  
Haseeb Anwar ◽  
Osman Asghar Mirza ◽  
Qasim Ali ◽  
Muhammad Umar Ijaz ◽  
...  
Keyword(s):  
Oral Administration ◽  
Gut Microbiome ◽  
Drug Target ◽  
Membrane Transporters ◽  
Intestinal Microbiome ◽  
Albino Rats ◽  
Body Organ ◽  
Total Absorbance ◽  
Research World

In the contemporary research world, the intestinal microbiome is now envisioned as a new body organ. Recently, the gut microbiome represents a new drug target in the gut, since various orthologues of intestinal drug transporters are also found present in the microbiome that lines the small intestine of the host. Owing to this, absorbance of sulpiride by the gut microbiome in an in vivo albino rats model was assessed after the oral administration with a single dose of 20mg/kg b.w. The rats were subsequently sacrificed at 2, 3, 4, 5 and 6 hours post oral administration to collect the gut microbial mass pellet. The drug absorbance by the gut microbiome was determined by pursuing the microbial lysate through RP-HPLC-UV. Total absorbance of sulpiride by the whole gut microbiome and drug absorbance per milligram of microbial pellet were found significantly higher at 4 hours post-administration as compared to all other groups. These results affirm the hypothesis that the structural homology between membrane transporters of the gut microbiome and intestinal epithelium of the host might play an important role in drug absorbance by gut microbes in an in vivo condition.

3D printed permeation module to monitor interaction of cell membrane transporters with exogenic compounds in real-time

2021 ◽  
Vol 1153 ◽  
pp. 338296
Author(s):  
Hana Sklenářová ◽  
Michaela Rosecká ◽  
Burkhard Horstkotte ◽  
Petr Pávek ◽  
Manuel Miró ◽  
...  
Keyword(s):  
Cell Membrane ◽  
Real Time ◽  
Membrane Transporters ◽  
3D Printed

Synthetic membrane transporters

2002 ◽  
Vol 6 (6) ◽  
pp. 749-756 ◽  
Author(s):  
J.Middleton Boon ◽  
Bradley D Smith
Keyword(s):  
Membrane Transporters ◽  
Synthetic Membrane

Calcium- and potassium-permeable plasma membrane transporters are activated by copper inArabidopsisroot tips: linking copper transport with cytosolic hydroxyl radical production

2012 ◽  
Vol 36 (4) ◽  
pp. 844-855 ◽  
Author(s):  
ANA RODRIGO-MORENO ◽  
NURIA ANDRÉS-COLÁS ◽  
CHARLOTTE POSCHENRIEDER ◽  
BENET GUNSÉ ◽  
LOLA PEÑARRUBIA ◽  
...  
Keyword(s):  
Plasma Membrane ◽  
Hydroxyl Radical ◽  
Copper Transport ◽  
Membrane Transporters ◽  
Radical Production

scholarly journals Role of human placental apical membrane transporters in the efflux of glyburide, rosiglitazone, and metformin

2010 ◽  
Vol 202 (4) ◽  
pp. 383.e1-383.e7 ◽  
Author(s):  
Sarah J. Hemauer ◽  
Svetlana L. Patrikeeva ◽  
Tatiana N. Nanovskaya ◽  
Gary D.V. Hankins ◽  
Mahmoud S. Ahmed
Keyword(s):  
Apical Membrane ◽  
Membrane Transporters

Conformationally Controlled Oligocholate Membrane Transporters: Learning through Water Play

2013 ◽  
Vol 46 (12) ◽  
pp. 2763-2772 ◽  
Author(s):  
Yan Zhao ◽  
Hongkwan Cho ◽  
Lakmini Widanapathirana ◽  
Shiyong Zhang
Keyword(s):  
Membrane Transporters
Sign in / Sign up

Export Citation Format

Share Document