Metastatic Brain Tumors: Viewpoint: Whole Brain Radiation Therapy

2015 ◽  
pp. 241-248
Author(s):  
William F. Regine ◽  
Sarah F. Grabowski ◽  
Roy A. Patchell
Keyword(s):  
Radiation Therapy ◽  
Brain Tumors ◽  
Whole Brain Radiation Therapy ◽  
Metastatic Brain Tumors ◽  
Whole Brain ◽  
Whole Brain Radiation ◽  
Brain Radiation

Gamma Knife Surgery for Metastatic Brain Tumors from Lung Cancer without Prophylactic Whole Brain Radiation Therapy

Radiosurgery ◽  
2006 ◽  
pp. 186-198 ◽  
Author(s):  
Toru Serizawa ◽  
Yoshinori Higuchi ◽  
Junichi Ono ◽  
Shinji Matsuda ◽  
Toshihiko Iuchi ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Radiation Therapy ◽  
Brain Tumors ◽  
Gamma Knife ◽  
Gamma Knife Surgery ◽  
Whole Brain Radiation Therapy ◽  
Metastatic Brain Tumors ◽  
Whole Brain ◽  
Whole Brain Radiation ◽  
Brain Radiation

scholarly journals The Role of Surgery, Radiosurgery and Whole Brain Radiation Therapy in the Management of Patients with Metastatic Brain Tumors

2012 ◽  
Vol 2012 ◽  
pp. 1-10 ◽  
Author(s):  
Thomas L. Ellis ◽  
Matthew T. Neal ◽  
Michael D. Chan
Keyword(s):  
Radiation Therapy ◽  
Brain Tumors ◽  
Brain Metastases ◽  
Treatment Options ◽  
Whole Brain Radiation Therapy ◽  
Management Options ◽  
Whole Brain ◽  
Whole Brain Radiation ◽  
Brain Radiation

Brain tumors constitute the most common intracranial tumor. Management of brain metastases has become increasingly complex as patients with brain metastases are living longer and more treatment options develop. The goal of this paper is to review the role of stereotactic radiosurgery (SRS), whole brain radiation therapy (WBRT), and surgery, in isolation and in combination, in the contemporary treatment of brain metastases. Surgery and SRS both offer management options that may help to optimize therapy in selected patients. WBRT is another option but can lead to late toxicity and suboptimal local control in longer term survivors. Improved prognostic indices will be critical for selecting the best therapies. Further prospective trials are necessary to continue to elucidate factors that will help triage patients to the proper brain-directed therapy for their cancer.

Gamma knife treatment for multiple metastatic brain tumors compared with whole-brain radiation therapy

2000 ◽  
Vol 93 (supplement_3) ◽  
pp. 32-36 ◽  
Author(s):  
Toru Serizawa ◽  
Toshihiko Iuchi ◽  
Junichi Ono ◽  
Naokatsu Saeki ◽  
Katsunobu Osato ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Gamma Knife ◽  
Gamma Knife Radiosurgery ◽  
Cerebral Metastases ◽  
Whole Brain Radiation Therapy ◽  
Whole Brain ◽  
Content Type ◽  
Whole Brain Radiation ◽  
Brain Radiation ◽  
Fine Print

Object. The purpose of this retrospective study was to compare the effectiveness of gamma knife radiosurgery (GKS) for multiple cerebral metastases with that of whole-brain radiation therapy (WBRT). Methods. Ninety-six consecutive patients with cerebral metastases from nonsmall cell lung cancer were treated between 1990 and 1999. The entry criteria were the presence of between one and 10 multiple brain lesions at initial diagnosis, no surgically inaccessible tumors with more than a 30-mm diameter, no carcinomatous meningitis, and more than 2 months of life expectancy. The patients were divided into two groups: the GKS group (62 patients) and the WBRT group (34 patients). In the GKS group, large lesions (> 30 mm) were removed surgically and all other small lesions (≤ 30 mm) were treated by GKS. New distant lesions were treated by repeated GKS without prophylactic WBRT. In the WBRT group, the patients were treated by the traditional combined therapy of WBRT and surgery. In both groups, chemotherapy was administered according to the primary physician's protocol. The two groups did not differ in terms of age, sex, initial Karnofsky Performance Scale (KPS) score, type, lesion number, and size of lesion, systemic control, and chemotherapy. Neurological survival and qualitative survival of the GKS group were longer than those of the WBRT group. In multivariate analysis, significant poor prognostic factors were systemically uncontrolled patients, WBRT group, and poor initial KPS score. Conclusions. Gamma knife radiosurgery without prophylactic WBRT could be a primary choice of treatment for patients with as many as 10 cerebral metastases from nonsmall cell cancer.

scholarly journals BRAINSTORM: A Multi-Institutional Phase 1/2 Study of RRx-001 in Combination With Whole Brain Radiation Therapy for Patients With Brain Metastases

2020 ◽  
Vol 107 (3) ◽  
pp. 478-486
Author(s):  
Michelle M. Kim ◽  
Hemant A. Parmar ◽  
Matthew Schipper ◽  
Theresa Devasia ◽  
Madhava P. Aryal ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Brain Metastases ◽  
Phase 1 ◽  
Whole Brain Radiation Therapy ◽  
Whole Brain ◽  
Whole Brain Radiation ◽  
Brain Radiation
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