Focal Drug Delivery in Inner Ear Therapy

2013 ◽  
pp. 215-224
Author(s):  
Jing Zou
Keyword(s):  
Drug Delivery ◽  
Inner Ear

Drug Delivery to the Inner Ear: Strategies and Their Therapeutic Implications for Sensorineural Hearing Loss

2012 ◽  
Vol 9 (3) ◽  
pp. 231-242 ◽  
Author(s):  
Teresa Rivera ◽  
Lorena Sanz ◽  
Guadalupe Camarero ◽  
Isabel Varela-Nieto
Keyword(s):  
Drug Delivery ◽  
Hearing Loss ◽  
Sensorineural Hearing Loss ◽  
Inner Ear ◽  
Sensorineural Hearing ◽  
Therapeutic Implications

scholarly journals Development of thermosensitive poloxamer 407-based microbubble gel with ultrasound mediation for inner ear drug delivery

Drug Delivery ◽  
2021 ◽  
Vol 28 (1) ◽  
pp. 1256-1271
Author(s):  
Ai-Ho Liao ◽  
Cheng-Ping Shih ◽  
Ming-Wei Li ◽  
Yi-Chun Lin ◽  
Ho-Chiao Chuang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Inner Ear ◽  
Poloxamer 407

Porous Silicon as a Nanomaterial for Disperse Transport Systems of Targeted Drug Delivery to the Inner Ear

2018 ◽  
Vol 63 (9) ◽  
pp. 1352-1360 ◽  
Author(s):  
Yu. M. Spivak ◽  
A. O. Belorus ◽  
A. A. Panevin ◽  
S. G. Zhuravskii ◽  
V. A. Moshnikov ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Porous Silicon ◽  
Inner Ear ◽  
Targeted Drug Delivery ◽  
Transport Systems ◽  
Targeted Drug

Special Issue on Advanced Drug Delivery Approaches for Inner Ear Therapeutics

2019 ◽  
Vol 126 ◽  
pp. 1-2
Author(s):  
Vibhuti Agrahari ◽  
Ibrahima Youm ◽  
Vivek Agrahari
Keyword(s):  
Drug Delivery ◽  
Inner Ear ◽  
Special Issue

scholarly journals Promising Applications of Nanoparticles in the Treatment of Hearing Loss

2021 ◽  
Vol 9 ◽  
Author(s):  
Zilin Huang ◽  
Qiang Xie ◽  
Shuang Li ◽  
Yuhao Zhou ◽  
Zuhong He ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Hearing Loss ◽  
Inner Ear ◽  
Drug Delivery System ◽  
Clinical Application ◽  
Delivery System ◽  
Diagnosis And Treatment ◽  
Biological Research ◽  
Medical Applications ◽  
Traditional Treatment

Hearing loss is one of the most common disabilities affecting both children and adults worldwide. However, traditional treatment of hearing loss has some limitations, particularly in terms of drug delivery system as well as diagnosis of ear imaging. The blood–labyrinth barrier (BLB), the barrier between the vasculature and fluids of the inner ear, restricts entry of most blood-borne compounds into inner ear tissues. Nanoparticles (NPs) have been demonstrated to have high biocompatibility, good degradation, and simple synthesis in the process of diagnosis and treatment, which are promising for medical applications in hearing loss. Although previous studies have shown that NPs have promising applications in the field of inner ear diseases, there is still a gap between biological research and clinical application. In this paper, we aim to summarize developments and challenges of NPs in diagnostics and treatment of hearing loss in recent years. This review may be useful to raise otology researchers’ awareness of effect of NPs on hearing diagnosis and treatment.

scholarly journals A Totally Implantable Drug Delivery System for Local Therapy of the Middle and Inner Ear

1997 ◽  
Vol 76 (8) ◽  
pp. 567-570 ◽  
Author(s):  
Rolf Lehner ◽  
Heribert Brugger ◽  
Marcus M. Maassen ◽  
Hans-Peter Zenner
Keyword(s):  
Drug Delivery ◽  
Inner Ear ◽  
Drug Delivery System ◽  
Delivery System ◽  
Drug Application ◽  
Local Therapy ◽  
Trophic Factors ◽  
Mastoid Cavity ◽  
Round Window Membrane ◽  
Wide Range

Local therapy of middle and inner ear diseases is being used, but is restricted to cases of ear drum perforation or to repeated invasive intratympanic drug application by the physician. In accordance with the Medical Device Directive (class III), a bone-anchored, totally implantable drug delivery system (TI-DDS) has been developed. It includes a micropump for subcutaneous, patient-controlled activation, a drug reservoir and a septum port. A thin guide-wired catheter leads from the pump outlet to the point of application in the mastoid or middle ear cavities. Local inner ear therapy with suitable drugs is possible by positioning the catheter's end near the round window membrane. The system requires no battery and will offer a wide range of patient-controlled bolus applications (25 μl per activation). We first analyzed the three-dimensional implantation geometry of the mastoid cavity. Basic micromechanical problems have been solved in order to create several prototypes. The TI-DDS has already undergone extensive in vitro testing. Recent results of pump rate precision and digital pressure force testing are promising. Local drug treatment for conditions such as lidocaine-sensitive tinnitus, secretory otitis media, Meniere's disease, localized pain and intralesional cancer is under discussion. Furthermore, local application of future biotechnological trophic factors for inner ear treatment is anticipated. The basic engineering is completed and initial animal tests are in preparation.

Regulated Chitosan-Based Inner-Ear Drug Delivery

2012 ◽  
Vol 147 (2_suppl) ◽  
pp. P92-P92
Author(s):  
Shayanne A. Lajud ◽  
Zhao Han ◽  
Andres Bur ◽  
Samudra Sanyal ◽  
Orysia Bezpalko ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Inner Ear

scholarly journals Inner Ear Drug Delivery

2019 ◽  
Vol 72 (7) ◽  
pp. 22
Author(s):  
Sueanne Phan
Keyword(s):  
Drug Delivery ◽  
Inner Ear

scholarly journals Nanocarriers for drug delivery to the inner ear: Physicochemical key parameters, biodistribution, safety and efficacy

2021 ◽  
Vol 592 ◽  
pp. 120038
Author(s):  
Céline Jaudoin ◽  
Florence Agnely ◽  
Yann Nguyen ◽  
Evelyne Ferrary ◽  
Amélie Bochot
Keyword(s):  
Drug Delivery ◽  
Inner Ear ◽  
Safety And Efficacy

A Novel Controlled Local Drug Delivery System for Inner Ear Disease

2008 ◽  
Vol 118 (4) ◽  
pp. 706-711 ◽  
Author(s):  
David P. Paulson ◽  
Waleed Abuzeid ◽  
Hao Jiang ◽  
Tomoyuki Oe ◽  
Bert W. O'Malley ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Inner Ear ◽  
Drug Delivery System ◽  
Delivery System ◽  
Local Drug Delivery ◽  
Inner Ear Disease ◽  
Local Drug Delivery System
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