Toward a Computational Model of Hypothesis Formation and Model Building in Science

Modeling complexity: cognitive constraints and computational model-building in integrative systems biology

History & Philosophy of the Life Sciences ◽

10.1007/s40656-017-0183-9 ◽

2018 ◽

Vol 40 (1) ◽

Cited By ~ 6

Author(s):

Miles MacLeod ◽

Nancy J. Nersessian

Keyword(s):

Systems Biology ◽

Computational Model ◽

Model Building ◽

Cognitive Constraints

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The Entropic Envelope

Leonardo ◽

10.1162/leon_a_01478 ◽

2019 ◽

Vol 52 (5) ◽

pp. 455-460

Author(s):

Hector Rodriguez

Keyword(s):

Computational Model ◽

Model Building ◽

Image Sequences ◽

Computation Model ◽

Temporal Experience ◽

Moving Image ◽

Information Theoretic ◽

Cinema Studies

This article introduces a computational model of the temporal experience of moving image sequences. The heart of the model, the concept of an entropic envelope, is based on information theoretic ideas. The concept is first described informally and then explained in a more mathematically precise manner. The article finally concludes with tentative reflections on the methodology of computation model building in cinema studies.

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Precompetitive preclinical ADME/Tox data: set it free on the web to facilitate computational model building and assist drug development

Lab on a Chip ◽

10.1039/b917760b ◽

2010 ◽

Vol 10 (1) ◽

pp. 13-22 ◽

Cited By ~ 46

Author(s):

Sean Ekins ◽

Antony J. Williams

Keyword(s):

Drug Development ◽

Computational Model ◽

Model Building ◽

Data Set ◽

The Web

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Object-oriented computational model building of aircraft flight dynamics and systems

Aerospace Science and Technology ◽

10.1016/s1270-9638(99)80036-4 ◽

1999 ◽

Vol 3 (3) ◽

pp. 115-126 ◽

Cited By ~ 17

Author(s):

D. Moormann ◽

P.J. Mosterman ◽

G. Looye

Keyword(s):

Computational Model ◽

Model Building ◽

Object Oriented ◽

Flight Dynamics ◽

Aircraft Flight

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The Art and Science of Building a Computational Model to Understand Hemostasis

Seminars in Thrombosis and Hemostasis ◽

10.1055/s-0041-1722861 ◽

2021 ◽

Vol 47 (02) ◽

pp. 129-138

Author(s):

Karin Leiderman ◽

Suzanne S. Sindi ◽

Dougald M. Monroe ◽

Aaron L. Fogelson ◽

Keith B. Neeves

Keyword(s):

Blood Flow ◽

Computational Model ◽

Thrombin Generation ◽

Computational Models ◽

Model Building ◽

Hemophilia A ◽

Complex Dynamics ◽

Thrombus Formation ◽

Model Builder ◽

Platelet Deposition

AbstractComputational models of various facets of hemostasis and thrombosis have increased substantially in the last decade. These models have the potential to make predictions that can uncover new mechanisms within the complex dynamics of thrombus formation. However, these predictions are only as good as the data and assumptions they are built upon, and therefore model building requires intimate coupling with experiments. The objective of this article is to guide the reader through how a computational model is built and how it can inform and be refined by experiments. This is accomplished by answering six questions facing the model builder: (1) Why make a model? (2) What kind of model should be built? (3) How is the model built? (4) Is the model a “good” model? (5) Do we believe the model? (6) Is the model useful? These questions are answered in the context of a model of thrombus formation that has been successfully applied to understanding the interplay between blood flow, platelet deposition, and coagulation and in identifying potential modifiers of thrombin generation in hemophilia A.

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Model Building in Economics

10.1017/cbo9781139507684 ◽

2014 ◽

Cited By ~ 9

Author(s):

Lawrence A. Boland

Keyword(s):

Model Building

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The sense of presence in virtual environments:

Zeitschrift für Medienpsychologie ◽

10.1026//1617-6383.15.2.69 ◽

2003 ◽

Vol 15 (2) ◽

pp. 69-71 ◽

Cited By ~ 84

Author(s):

Thomas W. Schubert

Keyword(s):

Virtual Environments ◽

Coding Theory ◽

Model Building ◽

Self Report ◽

Survey Study ◽

Spatial Presence ◽

Component Structure ◽

Sense Of Presence ◽

Being There ◽

Measure Sense

Abstract. The sense of presence is the feeling of being there in a virtual environment. A three-component self report scale to measure sense of presence is described, the components being sense of spatial presence, involvement, and realness. This three-component structure was developed in a survey study with players of 3D games (N = 246) and replicated in a second survey study (N = 296); studies using the scale for measuring the effects of interaction on presence provide evidence for validity. The findings are explained by the Potential Action Coding Theory of presence, which assumes that presence develops from mental model building and suppression of the real environment.

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