In vivo Detection of Nitric Oxide: Combining EPR and NMR

2001 ◽  
pp. 131-141
Author(s):  
Lawrence J. Berliner ◽  
Hirotada Fujii
Keyword(s):  
Nitric Oxide ◽  
In Vivo Detection

C12. Performances and applicability of electrochemical NO-sensor for in vivo detection of nitric oxide in tumor-bearing mice

Nitric Oxide ◽  
2007 ◽  
Vol 17 ◽  
pp. 22-23
Author(s):  
S. Griveau ◽  
C. Dumézy ◽  
J. Seguin ◽  
G.G. Chabot ◽  
D. Scherman ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Tumor Bearing ◽  
In Vivo Detection ◽  
No Sensor

In vivo detection of inducible nitric oxide synthase in rodent gliomas

2010 ◽  
Vol 48 (5) ◽  
pp. 691-703 ◽  
Author(s):  
Rheal A. Towner ◽  
Nataliya Smith ◽  
Sabrina Doblas ◽  
Philippe Garteiser ◽  
Yasuko Watanabe ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Inducible Nitric Oxide Synthase ◽  
In Vivo Detection ◽  
Oxide Synthase ◽  
Inducible Nitric Oxide

scholarly journals Facilitation of Molecular Motion in Nanoparticles and Development of Turn-on Photoacoustic Bioprobe for in Vivo Detection of Nitric Oxide in Encephalitis

2020 ◽  
Author(s):  
Ji Qi ◽  
Leyan Feng ◽  
Xiaoyan Zhang ◽  
Haoke Zhang ◽  
Liwen Huang ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Molecular Probe ◽  
Energy Transformation ◽  
Disease Evolution ◽  
Turn On ◽  
In Vivo Detection ◽  
Specificity And Sensitivity ◽  
Intramolecular Motion ◽  
Transformation Processes

Nitric oxide (NO) is an important signaling molecule overexpressed in many diseases, thus the development of NO-activatable probes is of vital significance for monitoring related diseases. However, sensitive photoacoustic (PA) probes for detecting NO-associated complicated diseases (e.g., encephalitis), has yet to be developed. Herein, we report a NO-activated PA probe for in vivo detection of encephalitis by tuning the molecular geometry and energy transformation processes. A strong donor-acceptor structure with good conjugation can be obtained after NO treatment, along with the active intramolecular motion, significantly boosting “turn-on” near-infrared PA property. The molecular probe exhibits high specificity and sensitivity towards NO over interfering reactive species. Noninvasive in vivo imaging indicates that PA signal lights up in lipopolysaccharide-induced encephalitis with a high signal-to-background ratio of 15.7. Further studies reveal that the probe is also capable of differentiating encephalitis in different severities, being beneficial for understanding the disease evolution processes and drug screening. This work will inspire more insights into the development of high-performing NO-activated PA probes for advanced diagnosis by making full use of intramolecular motion and energy transformation processes.

scholarly journals Facilitation of Molecular Motion in Nanoparticles and Development of Turn-on Photoacoustic Bioprobe for in Vivo Detection of Nitric Oxide in Encephalitis

2020 ◽  
Author(s):  
Ji Qi ◽  
Leyan Feng ◽  
Xiaoyan Zhang ◽  
Haoke Zhang ◽  
Liwen Huang ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Molecular Probe ◽  
Energy Transformation ◽  
Disease Evolution ◽  
Turn On ◽  
In Vivo Detection ◽  
Specificity And Sensitivity ◽  
Intramolecular Motion ◽  
Transformation Processes

Nitric oxide (NO) is an important signaling molecule overexpressed in many diseases, thus the development of NO-activatable probes is of vital significance for monitoring related diseases. However, sensitive photoacoustic (PA) probes for detecting NO-associated complicated diseases (e.g., encephalitis), has yet to be developed. Herein, we report a NO-activated PA probe for in vivo detection of encephalitis by tuning the molecular geometry and energy transformation processes. A strong donor-acceptor structure with good conjugation can be obtained after NO treatment, along with the active intramolecular motion, significantly boosting “turn-on” near-infrared PA property. The molecular probe exhibits high specificity and sensitivity towards NO over interfering reactive species. Noninvasive in vivo imaging indicates that PA signal lights up in lipopolysaccharide-induced encephalitis with a high signal-to-background ratio of 15.7. Further studies reveal that the probe is also capable of differentiating encephalitis in different severities, being beneficial for understanding the disease evolution processes and drug screening. This work will inspire more insights into the development of high-performing NO-activated PA probes for advanced diagnosis by making full use of intramolecular motion and energy transformation processes.

Near infrared spectroscopy of nitrosyl haemoglobin - relevance to in vivo detection of nitric oxide

1996 ◽  
Vol 24 (3) ◽  
pp. 448S-448S ◽  
Author(s):  
CHRIS E. COOPER ◽  
J. SPRINGETT ANGELIKI PANAGIOTOPOULUOROGER ◽  
JULIET PENRICE
Keyword(s):  
Nitric Oxide ◽  
Infrared Spectroscopy ◽  
Near Infrared Spectroscopy ◽  
Near Infrared ◽  
In Vivo Detection
Sign in / Sign up

Export Citation Format

Share Document