Renal Structural Changes in Patients with Type 1 Diabetes and Microalbuminuria

2000 ◽  
pp. 211-223 ◽  
Author(s):  
Hans-Jacob Bangstad ◽  
Susanne Rudberg ◽  
Ruth Østerby
Keyword(s):  
Type 1 Diabetes ◽  
Structural Changes

Structural changes in erythrocyte membranes under type 1 diabetes mellitus

2008 ◽  
Vol 21 (2) ◽  
pp. 211-214
Author(s):  
Nataliya Sybirna ◽  
Tetyana Buslyk ◽  
Nataliya Klymyshyn ◽  
Andriy Hnatush ◽  
Maria Duk ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Structural Changes ◽  
Erythrocyte Membranes

scholarly journals How the sialylation level of serum N-acetyl-β-D-glucosaminidase a form in type 1 diabetes mellitus influences its activity?

2014 ◽  
Vol 79 (12) ◽  
pp. 1491-1503
Author(s):  
Vesna Jovanovic ◽  
Jelena Acimovic ◽  
Vesna Dimitrijevic-Sreckovic ◽  
Ljuba Mandic
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Structural Changes ◽  
Negative Charge ◽  
Total Serum ◽  
Secondary Complications ◽  
Isoenzyme Patterns ◽  
Healthy Persons

It has been verified that serum N-acetyl-?-D-glucosaminidase (NAG) activity is elevated in diabetes, but there are no reports about changes of the sialic acid (SA) content in the carbohydrate parts of NAG A form and its influence on total NAG activity changes in type 1 diabetes mellitus patients without and with secondary complications. NAG A forms were isolated, purified and characterized from the serum of 81 IDDM patients with and without secondary complications (retinopathy, polyneuropathy and nephropathy) and 25 healthy persons. The content of ?-2,6-bound SA and isoenzyme patterns of purified A form, total NAG and A form activities were determined. In all diabetic groups, A form sialylation levels were 2-3.5 times lower compared to control, while their acidities (fractions with pI 4.25-5.1) increased, particularly with progression of secondary complications. Total serum NAG activities and percentages of A form were significantly higher (P<0.001) in all diabetic groups and negatively correlated with the ?-2,6-bound SA content of the A form. In addition, they decreased as secondary diabetic complications became more complex. Observed changes could be the consequence of structural changes in the A form due to significant increase in its acidity, i.e. negative charge which originate from groups other than SA.

The branching pattern of villous capillaries and structural changes of placental terminal villi in type 1 diabetes mellitus

Placenta ◽  
2012 ◽  
Vol 33 (5) ◽  
pp. 343-351 ◽  
Author(s):  
M. Jirkovská ◽  
T. Kučera ◽  
J. Kaláb ◽  
M. Jadrníček ◽  
V. Niedobová ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Structural Changes ◽  
Branching Pattern ◽  
Terminal Villi

New approaches to early diagnostic of microangiopathy in patients with type 1 diabetes mellitus

2015 ◽  
Vol 61 (5) ◽  
pp. 43-47
Author(s):  
Evgeniy Sergeevich Krutikov ◽  
Viktoriya Andreevna Zhitova
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Recovery Time ◽  
Structural Changes ◽  
Diabetic Microangiopathy ◽  
Control Group ◽  
Functional Disorders ◽  
Functional Tests ◽  
Early Diagnostic

Aim — the development of method for early diagnosis of microangiopathy in patients with type 1 diabetes mellitus (DM) by capillaroscopy with functional tests: the cuff occlusion of the upper extremity, tests with the cooling and heat exposures on the upper extremity.Material and methods. We investigated 54 patients with DM type I (mean age 24,1±3.2 years), who were divided into 2 groups: I group — 28 (51.6%) patients with duration DM <5 years; group II — 26 (48.4%) with duration DM >7 years. All the patients were underwent complex laboratory and instrumental examinations and also capillaroscopy and functional tests. Control group was consisting of 26 healthy people.Results. We revealed early stages of the diabetic microangiopathy even before the appearance of structural changes in patients with DM type at functional tests. We were identified the functional disorders: increasing recovery time of capillaroscopic parameters after carrying out functional tests to baseline versus control.Conclusion. We were to diagnose structural changes of microcirculation in diabetic patients with disease duration more than 7 years by capillaroscopy. In the early stages of the disease we were observed functional disorders which appearance before the structural changes using functional tests. It was lengthened recovery time of capillaroscopic dates after carrying out functional tests to baseline values in comparison with the control group. Recovery time may be used as early diagnostic criteria of diabetic microangiopathy when carrying out functional tests in patients with DM.

scholarly journals Type 1 diabetes mellitus induces structural changes and molecular remodelling in the rat kidney

2018 ◽  
Vol 449 (1-2) ◽  
pp. 9-25 ◽  
Author(s):  
Raphael M. Singh ◽  
Frank C. Howarth ◽  
Ernest Adeghate ◽  
Keshore Bidasee ◽  
Jaipaul Singh ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Structural Changes ◽  
Rat Kidney

Early Neurodegeneration of the Inner Retinal Layers in Type 1 Diabetes Mellitus

2015 ◽  
Vol 235 (3) ◽  
pp. 125-132 ◽  
Author(s):  
Fatih C. Gundogan ◽  
Fahrettin Akay ◽  
Salih Uzun ◽  
Umit Yolcu ◽  
Eylem Çağıltay ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Structural Changes ◽  
Linear Regression Analysis ◽  
Diabetic Patients ◽  
Ganglion Cell Complex ◽  
Healthy Controls ◽  
Retinal Layers ◽  
Rnfl Thickness ◽  
Type 1 Diabetic Patients

Purpose: This study explores retinal structural changes in type 1 diabetes without clinically diagnosed diabetic retinopathy (DR). Methods: Peripapillary retinal nerve fiber layer (RNFL) thickness, macular ganglion cell complex (GCC) thickness, and macular thickness (MT) were measured in 90 type 1 diabetic patients by using spectral domain optical coherence tomography. The values were compared with 100 sex- and age-matched healthy controls. The independent t test was used to assess differences in the mean age, mean diabetic and ocular parameters, and the thickness values between the diabetic and control groups. Multiple linear regression analysis was performed to investigate the correlation between the thickness values and diabetic and ocular parameters. Results: Whole-RNFL, the superior and inferior quadrants, and the superior half of the peripapillary RNFL thicknesses were significantly thinner in diabetic patients compared with controls (p < 0.05). GCC thicknesses in the average macular, outer temporal superior and outer temporal inferior sectors were significantly thinner in diabetic patients (p < 0.05). Central and average MTs were similar in both groups (p > 0.05). There were significant negative correlations of the duration of type 1 diabetes with the inner nasal MT, inner temporal superior GCC thickness, inner nasal inferior GCC thickness, and outer nasal superior GCC thickness (p < 0.05). Similarly, there were significant negative correlations of the level of HbA1c with the whole-RNFL thickness, superior-half-RNFL thickness, and superior-quadrant-RNFL thickness (p < 0.05). Conclusions: Type 1 diabetic patients without clinically diagnosed DR had neurodegeneration in the inner retinal layers compared with healthy controls.

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