Sensitivity analysis and risk assessment

1998 ◽  
pp. 99-109
Author(s):  
Kjell Stordahl
Keyword(s):  
Risk Assessment ◽  
Sensitivity Analysis

scholarly journals Quantitative Microbial Risk Assessment for Workers Exposed to Bioaerosol in Wastewater Treatment Plants Aimed at the Choice and Setup of Safety Measures

2018 ◽  
Vol 15 (7) ◽  
pp. 1490 ◽  
Author(s):  
Annalaura Carducci ◽  
Gabriele Donzelli ◽  
Lorenzo Cioni ◽  
Ileana Federigi ◽  
Roberto Lombardi ◽  
...  
Keyword(s):  
Risk Assessment ◽  
Sensitivity Analysis ◽  
Wastewater Treatment ◽  
Health Risk ◽  
Average Risk ◽  
Quantitative Microbial Risk Assessment ◽  
Exposure Limits ◽  
Microbial Risk Assessment ◽  
Microbial Risk ◽  
The Impact

Biological risk assessment in occupational settings currently is based on either qualitative or semiquantitative analysis. In this study, a quantitative microbial risk assessment (QMRA) has been applied to estimate the human adenovirus (HAdV) health risk due to bioaerosol exposure in a wastewater treatment plant (WWTP). A stochastic QMRA model was developed considering HAdV as the index pathogen, using its concentrations in different areas and published dose–response relationship for inhalation. A sensitivity analysis was employed to examine the impact of input parameters on health risk. The QMRA estimated a higher average risk in sewage influent and biological oxidation tanks (15.64% and 12.73% for an exposure of 3 min). Sensitivity analysis indicated HAdV concentration as a predominant factor in the estimated risk. QMRA results were used to calculate the exposure limits considering four different risk levels (one illness case per 100, 1.000, 10.000, and 100.000 workers): for 3 min exposures, we obtained 565, 170, 54, and 6 GC/m3 of HAdV. We also calculated the maximum time of exposure for each level for different areas. Our findings can be useful to better define the effectiveness of control measures, which would thus reduce the virus concentration or the exposure time.

scholarly journals Quantitative Health Risk Assessment of Wastewater Treatment Plant Worker Exposed to Staphylococcus Aureus Bioaerosol During Warm and Cold Periods: Disease Burden and Sensitivity Analysis

2021 ◽  
Author(s):  
Jia-xin Ma ◽  
Bei-bei Cui ◽  
Man-li Liu ◽  
Jie Yuan ◽  
Cheng Yan
Keyword(s):  
Risk Assessment ◽  
Staphylococcus Aureus ◽  
Sensitivity Analysis ◽  
Wastewater Treatment ◽  
Health Risk ◽  
Disease Burden ◽  
Quantitative Estimation ◽  
Ingestion Rate ◽  
Treatment Plant ◽  
Quantitative Microbial Risk Assessment

Abstract Biological treatment in wastewater treatment plants (WWTPs) releases high amounts of bioaerosols carrying a variety of pathogens. Quantitative microbial risk assessment (QMRA) is a framework prevalently intended for the quantitative estimation of health risks for occupational exposure scenarios (e.g. in WWTPs). However, the quantitative contributions of health-risk-estimate inputted variable parameters remain ambiguous. Therefore, this research aimed to study the disease burden of workers exposed to Staphylococcus aureus bioaerosol during warm and cold periods and to strictly quantify the contributions of the inputted parameters of disease burden by sensitivity analysis based on Monte Carlo simulation. The results showed that the disease health risk burden in the warm period was higher than in the cold period, disease health risk burden in the rotating-disc aeration mode was regularly higher than in the microporous aeration mode. The disease health risk burden of the workers with personal protective equipment (PPE) almost all satisfied the WHO benchmark (≤10E-6 DALYs pppy), and was consistently lower by one or two orders of magnitude than the workers without PPE in both warm and cold periods. Referring to the sensitivity analysis, exposure concentration and aerosol ingestion rate were the most and second predominant factor for the estimated risk in all exposure scenarios, respectively. The sensitivity of the removal fraction by employing PPE ranked third in the contribution to disease health risk burden. In addition, no remarkable differences were revealed in the sensitivity percentage ratio between warm and cold periods. This research can deepen the understanding of the QMRA framework and promote the development of sensitivity analysis, especially under various meteorological conditions (warm and cold periods).

Role of Component Sensitivity Analysis in the Risk Assessment of a Large and Complex System

2004 ◽  
pp. 2854-2859
Author(s):  
Sitakanta Mohanty ◽  
Budhi Sagar ◽  
Ron Janetzke ◽  
Gordon Wittmeyer ◽  
Wesley Patrick
Keyword(s):  
Complex System ◽  
Risk Assessment ◽  
Sensitivity Analysis

A Comparative Risk Assessment for Listeria monocytogenes in Prepackaged versus Retail-Sliced Deli Meat

2010 ◽  
Vol 73 (4) ◽  
pp. 612-619 ◽  
Author(s):  
SARAH ENDRIKAT ◽  
DANIEL GALLAGHER ◽  
RÉGIS POUILLOT ◽  
HEATHER HICKS QUESENBERRY ◽  
DAVID LaBARRE ◽  
...  
Keyword(s):  
Risk Assessment ◽  
Sensitivity Analysis ◽  
Listeria Monocytogenes ◽  
Shelf Life ◽  
Risk Ratio ◽  
Growth Inhibitor ◽  
Assessment Model ◽  
Growth Inhibitors ◽  
Comparative Risk ◽  
Inspection Service

Deli meat was ranked as the highest-risk ready-to-eat food vehicle of Listeria monocytogenes within the 2003 U.S. Food and Drug Administration and U.S. Department of Agriculture, Food Safety and Inspection Service risk assessment. The comparative risk of L. monocytogenes in retail-sliced versus prepackaged deli meats was evaluated with a modified version of this model. Other research has found that retail-sliced deli meats have both higher prevalence and levels of L. monocytogenes than have product sliced and packaged at the manufacturer level. The updated risk assessment model considered slicing location as well as the use of growth inhibitors. The per annum comparative risk ratio for the number of deaths from retail-sliced versus prepackaged deli meats was found to be 4.89, and the per-serving comparative risk ratio was 4.27. There was a significant interaction between the use of growth inhibitors and slicing location. Almost 70% of the estimated deaths occurred from retail-sliced product that did not possess a growth inhibitor. A sensitivity analysis, assessing the effect of the model's consumer storage time and shelf life assumptions, found that even if retail-sliced deli meats were stored for a quarter of the time prepackaged deli meats were stored, retail-sliced product is 1.7 times more likely to result in death from listeriosis. Sensitivity analysis also showed that the shelf life assumption had little effect on the comparative risk ratio.

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