Evidence that Changes in Blood Oxygen Affinity Modulate Oxygen Delivery: Implications for Control of Tissue PO2 Gradients

1988 ◽  
pp. 309-313 ◽  
Author(s):  
Robert D. Woodson
Keyword(s):  
Oxygen Delivery ◽  
Oxygen Affinity ◽  
Blood Oxygen ◽  
Tissue Po2 ◽  
Blood Oxygen Affinity ◽  
Po2 Gradients

Reduction of human blood O2 affinity using dihydroxyacetone, phosphate, and pyruvate

1979 ◽  
Vol 47 (3) ◽  
pp. 478-481 ◽  
Author(s):  
H. H. Kerr ◽  
G. A. Pantely ◽  
J. Metcalfe ◽  
J. E. Welch
Keyword(s):  
Human Blood ◽  
Sodium Salt ◽  
Oxygen Delivery ◽  
Oxygen Affinity ◽  
Solution Concentration ◽  
Dihydroxyacetone Phosphate ◽  
Blood Oxygen ◽  
Control Value ◽  
Blood Oxygen Affinity ◽  
2,3 Dpg

Human blood oxygen affinity (BOA) was measured after blood from six normal donors was incubated with 4 concentrations of dihydroxyacetone (0.022, 0.044, 0.088, and 0.175 M) plus equimolar disodium phosphate and pyruvate (sodium salt) (0.013, 0.025, 0.05 and 0.1 M) in solutions labeled DDP X 1, DDP X 2, DDP X 4, and DDP X 8, respectively. Blood P50 rose (BOA was reduced) from a control value of 26.0 +/- 0.4 Torr (mean +/- SD) to 29.4 +/- 0.6, 30.6 +/- 0.4, 31.9 +/- 0.15 and 33.3 +/- 1.4 Torr after 2 h of incubation at 37 degrees C with solutions DDP X 1, DDP X 2, DDP X 4, and DDP X 8, respectively. P50 changes at 2 h were 75% complete within 30 min. During these incubations, erythrocyte 2,3-diphosphoglycerate (2,3-DPG) concentration rose from 0.76 +/- 0.09 mol/mol Hb (control) to 1.09 +/- 0.17, 1.14 +/- 0.10, 1.33 +/- 0.15, and 1.45 +/- 0.25 mol/mol Hb with increasing solution concentration. BOA is decreased by an increase in erythrocyte 2,3-DPG. Reduced BOA may improve oxygen delivery to ischemic tissues.

Blood oxygen affinity in high- and low-altitude populations of the deer mouse

1982 ◽  
Vol 48 (1) ◽  
pp. 89-105 ◽  
Author(s):  
Lee R.G. Snyder ◽  
Stephen Born ◽  
Andrew J. Lechner
Keyword(s):  
Deer Mouse ◽  
Oxygen Affinity ◽  
Blood Oxygen ◽  
Blood Oxygen Affinity ◽  
Low Altitude

scholarly journals Temporal changes of plasma erythropoietin level in hypobaric hypoxic mice and the influence of an altered blood oxygen affinity.

1989 ◽  
Vol 39 (6) ◽  
pp. 833-846 ◽  
Author(s):  
Satoshi SHIMIZU ◽  
Susumu SAKATA ◽  
Yasunori ENOKI ◽  
Yoshimi OHGA ◽  
Izumi OKI ◽  
...  
Keyword(s):  
Oxygen Affinity ◽  
Temporal Changes ◽  
Blood Oxygen ◽  
Blood Oxygen Affinity ◽  
Altered Blood ◽  
Erythropoietin Level

scholarly journals Autosomal dominant polycythemia

Blood ◽  
1985 ◽  
Vol 66 (5) ◽  
pp. 1208-1214 ◽  
Author(s):  
JT Prchal ◽  
WM Crist ◽  
E Goldwasser ◽  
G Perrine ◽  
JF Prchal
Keyword(s):  
Autosomal Dominant ◽  
Oxygen Affinity ◽  
Colony Growth ◽  
Blood Oxygen ◽  
Autosomal Dominant Trait ◽  
Volume Measurements ◽  
Blood Oxygen Affinity ◽  
Low Levels ◽  
Stimulation Of

Two families with polycythemia inherited as an autosomal dominant trait are described. Serial hemoglobin determinations in multiple family members and RBC volume measurements in selected affected subjects documented their polycythemia. Measurements of arterial p02s, p50s, and blood oxygen affinity were normal in all affected individuals from each family who were tested. Erythropoietin (EPO) levels were low in affected individuals from family 1 and normal in affected members of family 2. Stimulation of in vitro CFU-E colony growth by low levels of EPO was significantly increased in subjects from family 1, but normal in those affected from family 2. We conclude that although the inheritance pattern for the polycythemia in both of these families appeared to be the same, the biologic defect leading to the disorder in each of these unique families was different. The precise mechanism of the increased EPO sensitivity noted in affected subjects from family 1 awaits elucidation.

scholarly journals The Circulatory Response to Acute Hypoxia in Octopus

1983 ◽  
Vol 104 (1) ◽  
pp. 59-71 ◽  
Author(s):  
M.J. WELLS ◽  
J. WELLS
Keyword(s):  
Oxygen Uptake ◽  
Acute Hypoxia ◽  
Oxygen Affinity ◽  
Octopus Vulgaris ◽  
Blood Oxygen ◽  
Total Oxygen ◽  
Circulatory Response ◽  
The Central Nervous System ◽  
Blood Oxygen Affinity ◽  
Cutaneous Respiration

Octopus vulgaris can regulate its oxygen uptake in a closed respirometer down to a Poo2 of less than 70 mmHg. As the tankwater Poo2 falls the hearts slow down. Pulse amplitudes and mean pressures fall in the afferent branchial vessels and in the dorsal aorta. Despite behavioural changes - expansion of the interbrachial web and extension of the arms - that might imply this, the proportion of the total oxygen uptake attributable to cutaneous respiration (less than 13%) does not alter as the external Poo2 falls. The response of the hearts to a low Poo2 is not affected by severing the nerve supply from the central nervous system, or by removal of the heart ganglia. It is evidently determined by oxygen lack and not by the accumulation of CO2 or other metabolites, since the same effects are achieved by placing the animals in water where the Poo2 has been reduced by boiling. The conclusion that regulation does not depend upon circulatory responses to hypoxia is considered in the light of recent work on the changes in blood oxygen affinity associated with acute hypoxia in cephalopods.

Physiological effects of lowered blood oxygen affinity in dogs

1978 ◽  
Vol 33 (3) ◽  
pp. 263-270 ◽  
Author(s):  
Michael A. Krall ◽  
James D. Bristow ◽  
J. Eugene Welch ◽  
James Metcalfe
Keyword(s):  
Oxygen Affinity ◽  
Physiological Effects ◽  
Blood Oxygen ◽  
Blood Oxygen Affinity

Postnatal regulation of canine oxygen delivery: erythrocyte components affecting Hb function

1980 ◽  
Vol 238 (1) ◽  
pp. H73-H79 ◽  
Author(s):  
P. A. Mueggler ◽  
G. Jones ◽  
J. S. Peterson ◽  
J. M. Bissonnette ◽  
R. D. Koler ◽  
...  
Keyword(s):  
Oxygen Affinity ◽  
Fetal Hemoglobin ◽  
Blood Oxygen ◽  
Oxygen Dissociation ◽  
Affinity Change ◽  
Blood Oxygen Affinity ◽  
Postnatal Change ◽  
2,3 Dpg

A rightward shift in the blood oxygen dissociation curve occurs during the 1st mo of canine life. A detailed peptide analysis indicated that dogs do not have a separate fetal hemoglobin. Other erythrocyte components such as ATP, K+, Na+, and H+ were excluded as significant mediators of the postnatal oxygen affinity change. Erythrocyte 2,3-DPG levels essentially zero in fetal dogs, increased rapidly during the 1st mo of canine life. There was a significant correlation between this postnatal 2,3-DPG increase and the postnatal decrease in blood oxygen affinity. Dialyzed hemolysates of fetal or adult canine blood have the same intrinsic oxygen affinity and the same response to normal adult levels of 2,3-DPG. Furthermore, the magnitude and direction of this 2,3-DPG-induced decrease in oxygen affinity in vitro are comparable to the in vivo postnatal change in oxygen affinity.

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