Copper- and Zinc-Binding Components in Rat Intestine

1974 ◽  
pp. 285-297 ◽  
Author(s):  
Gary W. Evans ◽  
Carole J. Hahn
Keyword(s):  
Zinc Binding ◽  
Rat Intestine ◽  
Copper And Zinc

scholarly journals Copper and Zinc Binding Specifically Induce the Aggregation of Human γ-D Crystallin

2015 ◽  
Vol 108 (2) ◽  
pp. 502a
Author(s):  
Liliana Quintanar ◽  
Evgene Serebryany ◽  
Jose Antonio Domínguez-Calva ◽  
Cameron Haasse-Pettingell ◽  
Jonathan A. King
Keyword(s):  
Zinc Binding ◽  
Copper And Zinc

Copper- and Zinc-Binding Protein Fractions in the Soluble Cytoplasm of Rat Tissues

1977 ◽  
Vol 5 (2) ◽  
pp. 425-427 ◽  
Author(s):  
DEREK S. NORTON ◽  
FRANK W. HEATON
Keyword(s):  
Binding Protein ◽  
Protein Fractions ◽  
Zinc Binding ◽  
Rat Tissues ◽  
Copper And Zinc

scholarly journals Identification of albumin as the plasma carrier for zinc absorption by perfused rat intestine

1979 ◽  
Vol 184 (3) ◽  
pp. 627-633 ◽  
Author(s):  
K T Smith ◽  
M L Failla ◽  
R J Cousins
Keyword(s):  
Affinity Chromatography ◽  
Gel Electrophoresis ◽  
Serum Zinc ◽  
Zinc Binding ◽  
Zinc Absorption ◽  
Rat Intestine ◽  
Protein Carrier ◽  
Mucosal Cells ◽  
Intestinal Mucosal Cells ◽  
Blue Sepharose

The isolated vascularly perfused rat intestine exhibits an obligatory need for a protein carrier in order to absorb zinc. Therefore this system is ideal for use as a model to identify the plasma carrier during zinc absorption. Affinity chromatography on Blue Sepharose CL-6B was employed to separate the major serum zinc-binding proteins in the portal effluent of the perfused intestine. It was found that 94% of newly absorbed 65Zn was transported in the portal serum-containing perfusate as an albumin-65Zn complex. The identity of albumin as the plasma carrier was confirmed by polyacrylamide-slab-gel electrophoresis. This evidence suggests that albumin is the plasma protein that is involved in removal of zinc from intestinal-mucosal cells and subsequent transport of the metal in portal blood to the liver.

Copper- and Zinc-binding Proteins in Sheep Liver and Intestine: Effects of Dietary Levels of the Metals

1980 ◽  
Vol 110 (3) ◽  
pp. 460-468 ◽  
Author(s):  
William W. Saylor ◽  
Franklin D. Morrow ◽  
Roland M. Leach
Keyword(s):  
Binding Proteins ◽  
Zinc Binding ◽  
Sheep Liver ◽  
Copper And Zinc

scholarly journals The Native Copper- and Zinc- Binding Protein Metallothionein Blocks Copper-Mediated Aβ Aggregation and Toxicity in Rat Cortical Neurons

PLoS ONE ◽  
2010 ◽  
Vol 5 (8) ◽  
pp. e12030 ◽  
Author(s):  
Roger S. Chung ◽  
Claire Howells ◽  
Emma D. Eaton ◽  
Lana Shabala ◽  
Kairit Zovo ◽  
...  
Keyword(s):  
Cortical Neurons ◽  
Binding Protein ◽  
Zinc Binding ◽  
Native Copper ◽  
Copper And Zinc ◽  
Aβ Aggregation ◽  
Rat Cortical Neurons

scholarly journals Hepatic copper–and zinc-binding proteins in ruminants

1974 ◽  
Vol 32 (2) ◽  
pp. 283-291 ◽  
Author(s):  
I Bremner ◽  
R. B Marshall
Keyword(s):  
Molecular Weight ◽  
Metal Binding ◽  
Binding Proteins ◽  
Mutual Interaction ◽  
Zinc Binding ◽  
Direct Function ◽  
Hepatic Copper ◽  
Copper And Zinc ◽  
Zn Concentration ◽  
Cu And Zn

1. A metal-binding fraction with a molecular weight of about 12000 in calf and sheep liver has been characterized as a metallothionein-like protein.2. The combined concentrations of copper and zinc in the fraction (as μg/g liver) are a direct function of liver Zn concentration.3. The relative proportions of Cu and Zn in the fraction are dependent on the Cu: Zn ratio in the liver.4. These findings may be relevant to the mutual interaction between Cu and Zn.

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