Role of Oxygen Availability to the Liver in Anesthesia-Induced Hepatotoxicity

Author(s):  
Simon Gelman
Keyword(s):  
2020 ◽  
Vol 139 (4) ◽  
Author(s):  
Florencia A. Rodriguez ◽  
Paola B. Reyna ◽  
Tamara Maggioni ◽  
Diego R. Giménez ◽  
Luciana Torre
Keyword(s):  

2016 ◽  
Vol 82 (15) ◽  
pp. 4673-4681 ◽  
Author(s):  
Claudia Capusoni ◽  
Stefania Arioli ◽  
Paolo Zambelli ◽  
M. Moktaduzzaman ◽  
Diego Mora ◽  
...  

ABSTRACTThe yeastDekkera bruxellensis, associated with wine and beer production, has recently received attention, because its high ethanol and acid tolerance enables it to compete withSaccharomyces cerevisiaein distilleries that produce fuel ethanol. We investigated how different cultivation conditions affect the acetic acid tolerance ofD. bruxellensis. We analyzed the ability of two strains (CBS 98 and CBS 4482) exhibiting different degrees of tolerance to grow in the presence of acetic acid under aerobic and oxygen-limited conditions. We found that the concomitant presence of acetic acid and oxygen had a negative effect onD. bruxellensisgrowth. In contrast, incubation under oxygen-limited conditions resulted in reproducible growth kinetics that exhibited a shorter adaptive phase and higher growth rates than those with cultivation under aerobic conditions. This positive effect was more pronounced in CBS 98, the more-sensitive strain. Cultivation of CBS 98 cells under oxygen-limited conditions improved their ability to restore their intracellular pH upon acetic acid exposure and to reduce the oxidative damage to intracellular macromolecules caused by the presence of acetic acid. This study reveals an important role of oxidative stress in acetic acid tolerance inD. bruxellensis, indicating that reduced oxygen availability can protect against the damage caused by the presence of acetic acid. This aspect is important for optimizing industrial processes performed in the presence of acetic acid.IMPORTANCEThis study reveals an important role of oxidative stress in acetic acid tolerance inD. bruxellensis, indicating that reduced oxygen availability can have a protective role against the damage caused by the presence of acetic acid. This aspect is important for the optimization of industrial processes performed in the presence of acetic acid.


2016 ◽  
Vol 43 (2) ◽  
pp. 114 ◽  
Author(s):  
Tino Colombi ◽  
Achim Walter

Soil compaction includes a set of underlying stresses that limit root growth such as increased impedance and limited oxygen availability. The aims of the present study were to (i) find acclimations of triticale (× Triticosecale) and soybean (Glycine max L.) roots to compacted soils in the field; (ii) reproduce these under controlled conditions; and (iii) associate these responses with soil physical properties. To this end, plants were grown at two different soil bulk densities in the field and under controlled conditions representing mature root systems and the seedling stage respectively. Diameters, lateral branching densities, the cortical proportion within the total root cross-section and the occurrence of cortical aerenchyma of main roots were quantified. Soil compaction caused decreasing root branching and increasing cortical proportions in both crops and environments. In triticale, root diameters and the occurrence of aerenchyma increased in response to compaction in the field and under controlled conditions. In soybean, these acclimations occurred at an initial developmental stage but due to radial root growth not in mature roots. These results showed that responses of root systems to compacted soils in the field are, to a large extent, reproducible under controlled conditions, enabling increased throughput, phenotyping-based breeding programs in the future. Furthermore, the occurrence of aerenchyma clearly indicated the important role of limited oxygen availability in compacted soils on root growth.


1998 ◽  
pp. 171-192
Author(s):  
Sarra K. Laycock ◽  
Xiaoping Zhang ◽  
Nahid Seyedi ◽  
Cong Zhao ◽  
Robert D. Bernstein ◽  
...  

1987 ◽  
Vol 187 (6) ◽  
pp. 451-459 ◽  
Author(s):  
J. Hamar ◽  
L. Dezsi ◽  
E. Adam ◽  
L. Egri ◽  
K. O. Netzer ◽  
...  

2017 ◽  
Vol 4 (4) ◽  
pp. 160850 ◽  
Author(s):  
Clemente Fernandez Arias ◽  
Cristina Fernandez Arias

Human red blood cells (RBCs) are normally phagocytized by macrophages of splenic and hepatic sinusoids at 120 days of age. The destruction of RBCs is ultimately controlled by antagonist effects of phosphatidylserine (PS) and CD47 on the phagocytic activity of macrophages. In this work, we introduce a conceptual model that explains RBC lifespan as a consequence of the dynamics of these molecules. Specifically, we suggest that PS and CD47 define a molecular algorithm that sets the timing of RBC phagocytosis. We show that significant changes in RBC lifespan described in the literature can be explained as alternative outcomes of this algorithm when it is executed in different conditions of oxygen availability. The theoretical model introduced here provides a unified framework to understand a variety of empirical observations regarding RBC biology. It also highlights the role of RBC lifespan as a key element of RBC homeostasis.


2016 ◽  
Vol 2016 ◽  
pp. 1-12 ◽  
Author(s):  
Ivette Pacheco-Leyva ◽  
Felipe Guevara Pezoa ◽  
Alvaro Díaz-Barrera

The Gram-negative bacteriumAzotobacter vinelandiican synthetize the biopolymer alginate that has material properties appropriate for plenty of applications in industry as well as in medicine. In order to settle the foundation for improving alginate production without compromising its quality, a better understanding of the polymer biosynthesis and the mechanism of regulation during fermentation processes is necessary. This knowledge is crucial for the development of novel production strategies. Here, we highlight the key aspects of alginate biosynthesis that can lead to producing an alginate with specific material properties with particular focus on the role of oxygen availability linked with the molecular mechanisms involved in the alginate production.


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