Retrolental Fibroplasia

1985 ◽  
pp. 189-234
Author(s):  
John T. Flynn
Keyword(s):  
Retrolental Fibroplasia

Retrolental Fibroplasia: A Hazard of Premature Birth

1950 ◽  
Vol 59 (2) ◽  
pp. 246-258 ◽  
Author(s):  
Harold Speert ◽  
Frederick C. Blodi ◽  
Algernon B. Reese
Keyword(s):  
Premature Birth ◽  
Retrolental Fibroplasia

Peripheral Choroiditis Simulating Retrolental Fibroplasia*

1950 ◽  
Vol 33 (9) ◽  
pp. 1417-1420 ◽  
Author(s):  
R.D. Harley ◽  
R.W. Mather
Keyword(s):  
Retrolental Fibroplasia

Retrolental Fibroplasia in Hypoxic Newborn

1980 ◽  
Vol 35 (3) ◽  
pp. 160-161
Author(s):  
JOHN NAIMAN ◽  
W. RICHARD GREEN ◽  
ARNALL PATZ
Keyword(s):  
Retrolental Fibroplasia

Retrolental Fibroplasia

1954 ◽  
Vol 1 (3) ◽  
pp. 607-623 ◽  
Author(s):  
Thaddeus S. Szewczyk
Keyword(s):  
Retrolental Fibroplasia

THE ABSORPTION OF VITAMIN A IN PREMATURELY BORN INFANTS

PEDIATRICS ◽  
1948 ◽  
Vol 1 (4) ◽  
pp. 505-511
Author(s):  
STEWART H. CLIFFORD ◽  
KATHLEEN FAHEY WELLER
Keyword(s):  
Vitamin A ◽  
Premature Infants ◽  
Test Dose ◽  
Water Soluble ◽  
Soluble Form ◽  
Oral Ingestion ◽  
Retrolental Fibroplasia ◽  
Practical Advantage ◽  
The Mean ◽  
Absorption Level

Forty-two premature infants were tested for vitamin A absorption after the oral ingestion of 0.5 cc. (35,000 U.S.P. units) of percomorph liver oil. Only three (7%) showed good absorption levels. The mean absorption level found from three to five hours after the test dose was 16 units of vitamin A. Forty-one were tested for vitamin A absorption after the oral ingestion of either 2 cc. or 3 cc. (16,000-24,000 U.S.P. units) of vitamin A in a vehicle of either alcohol or propylene glycol. Of these 37 (90%) showed good absorption levels. The mean absorption level found from three to five hours after the test dose was 85 units of vitamin A. Retrolental fibroplasia could not be prevented from developing in a certain number of premature infants' eyes by the daily oral administration of 5000 U.S.P. of vitamin A in an absorbable water soluble form. Even the addition of 20,000 U.S.P. units of vitamin A in oil by intramuscular injection failed to prevent the development of bilateral retrolental fibroplasia in one infant. If vitamin D follows the same laws of absorption as does vitamin A, the provision of both A and D in a readily absorbable form should be of great practical advantage to the prematurely born infant.

d-Penicillamine and Retinopathy of Prematurity

PEDIATRICS ◽  
1988 ◽  
Vol 82 (6) ◽  
pp. 951-952
Author(s):  
LAJOS LAKATOS
Keyword(s):  
Birth Weight ◽  
Vitamin E ◽  
Low Birth Weight ◽  
Retinopathy Of Prematurity ◽  
Very Low Birth Weight ◽  
Marked Decrease ◽  
Neonatal Period ◽  
Low Birth Weight Infants ◽  
Retrolental Fibroplasia ◽  
Clinical Observations

To the Editor.— The letter to the editor by Johnson et al1 and studies by others regarding vitamin E prophylaxis for retinopathy of prematurity suggest that further research into the prevention of retinopathy of prematurity should not be limited to vitamin E. On the basis of clinical observations we reported that d-penicillamine treatment in the neonatal period was associated with a marked decrease in the incidence of severe retrolental fibroplasia among the very low birth weight infants.2

Massive studies, minimal progress

PEDIATRICS ◽  
1977 ◽  
Vol 60 (5) ◽  
pp. 756-756
Author(s):  
J. F. L.
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Peer Group ◽  
Blood Gas ◽  
Low Birth Weight Infants ◽  
Multicenter Studies ◽  
Retrolental Fibroplasia ◽  
University Centers

Large, expensive, multidisciplined, multicenter studies present special problems to journals. The study by Kinsey et al. in this issue (p. 655) is a good example. This study was designed by a distinguished peer group. It was carried out in five university centers by 27 investigators, written up for publication by ten authors, evaluated by statisticians, and was ready for publication nearly nine years after the research was first begun. The goal of the study was a very good one. The authors hoped to define the level of PaO2 and the duration of exposure which could result in retrolental fibroplasia. Nearly 10,000 blood gas studies were carried out on 589 low-birth-weight infants.

Retrolental Fibroplasia and Blood Transfusion in Very Low-Birth-Weight Infants

PEDIATRICS ◽  
1981 ◽  
Vol 68 (6) ◽  
pp. 770-774 ◽  
Author(s):  
Linda M. Sacks ◽  
David B. Schaffer ◽  
Endla K. Anday ◽  
George J. Peckham ◽  
Maria Delivoria-Papadopoulos
Keyword(s):  
Birth Weight ◽  
Blood Transfusion ◽  
Low Birth Weight ◽  
Red Blood Cells ◽  
Blood Cells ◽  
Very Low Birth Weight ◽  
Statistical Significance ◽  
Low Birth Weight Infants ◽  
Retrolental Fibroplasia ◽  
Packed Red Blood Cells

The relative contribution of transfusions of adult blood to the development of retrolental fibroplasia (RLF) in very low-birth-weight infants was examined. Five years of experience with the expanded use of replacement and exchange transfusions in 90 infants with birth weight ≤1,250 gm was reviewed. Twenty percent of the infants developed cicatricial RLF. Exchange transfusion was not related to development of cicatricial RLF. The incidence of RLF in infants receiving ≥130 ml of packed red blood cells per kilogram of birth weight as replacement blood transfusion (RBT) was significantly higher (42.9%) than that in infants receiving 61 to 131 ml of packed red blood cells per kilogram (15.4%) and infants receiving ≤60 ml of packed red blood cells per kilogram (0%), P < .001. The need for RBT, however, was strongly correlated (r = .85, P < .001) with increasing duration of O2 therapy. When O2 therapy was controlled for, the association between RBT and RLF did not achieve statistical significance (P = .07). The association between RBT and RLF remained significant when adjusted for duration of therapy in fractional inspired oxygen (FIO2) >0.4. Further detailed studies of large numbers of susceptible infants are warranted to assess the magnitude of the contribution of transfusions of adult blood to development of RLF.

Vision Screening and Eye Examination in Children

PEDIATRICS ◽  
1986 ◽  
Vol 77 (6) ◽  
pp. 918-919 ◽  
Author(s):  
Keyword(s):  
Systemic Disease ◽  
Geographical Area ◽  
Visual Image ◽  
Careful Examination ◽  
Vision Screening ◽  
Newborn Period ◽  
Eye Muscle ◽  
Retrolental Fibroplasia ◽  
Eye Problems ◽  
Eye Examination

Vision screening and eye examination are important for the detection of conditions that distort or suppress the normal visual image and, ultimately, may lead to blindness in children. Examination of the eyes can and should be performed at any age, beginning in the newborn period. Vision screening should be performed at as early an age as is practicable. Conditions that interfere with vision are of grave import because visual stimuli are critical to the development of normal vision. Decreased visual acuity often contributes to inadequate school performance. In addition, retinal abnormalities, cataract, glaucoma, retinoblastoma, eye muscle imbalance, and systemic disease with ocular manifestations may all be identified by careful examination. Vision screening should be carried out as part of a regular plan of continuing care, beginning in the preschool years. Screening examinations may be effectively performed by paramedical personnel under appropriate medical supervision. As with other specialty areas, it is important for the pediatrician to establish contact with an area ophthalmologist in the same geographical area who is familiar with children's eye problems. A close working relationship with such a specialist will clarify questions about procedures for eye screening as well as indications for referral. TIMING OF EXAMINATION AND SCREENING Children should have age-appropriate assessment for eye problems in the newborn period and at subsequent health supervision visits. Vision screening can begin as early as 3 years of age. Infants at risk for eye problems, such as retrolental fibroplasia, or those with a family history of congenital cataracts, retinoblastoma, and metabolic and genetic diseases should have an ophthalmologic examination in the nursery.

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