The Activation of Pyruvate Dehydrogenase by Glucagon in Hepatocytes is Diminished by Phorbol Myristate Acetate: A role for Cytoplasmic Calcium in Dehydrogenase Regulation

Penta-O-galloyl-β-d-glucose inhibits phorbol myristate acetate-induced intereukin-8 gene expression in human monocytic U937 cells through its inactivation of nuclear factor-κB

International Immunopharmacology ◽

10.1016/j.intimp.2003.10.010 ◽

2004 ◽

Vol 4 (3) ◽

pp. 377-386 ◽

Cited By ~ 35

Author(s):

G.S. Oh ◽

H.O. Pae ◽

B.M. Choi ◽

H.S. Lee ◽

I.K. Kim ◽

...

Keyword(s):

Gene Expression ◽

Phorbol Myristate Acetate ◽

Nuclear Factor Κb ◽

Nuclear Factor ◽

U937 Cells ◽

Myristate Acetate

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Correlation between membrane potential changes and superoxide production in human granulocytes stimulated by phorbol myristate acetate. Evidence for defective activation in chronic granulomatous disease.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(19)85963-x ◽

1980 ◽

Vol 255 (5) ◽

pp. 1874-1878

Author(s):

J.C. Whitin ◽

C.E. Chapman ◽

E.R. Simons ◽

M.E. Chovaniec ◽

H.J. Cohen

Keyword(s):

Membrane Potential ◽

Chronic Granulomatous Disease ◽

Phorbol Myristate Acetate ◽

Superoxide Production ◽

Granulomatous Disease ◽

Myristate Acetate ◽

Human Granulocytes

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Tumor promoter phorbol myristate acetate inhibits Ca2+ influx through voltage-gated Ca2+ channels in two secretory cell lines, PC12 and RINm5F.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(17)42424-0 ◽

1986 ◽

Vol 261 (1) ◽

pp. 32-35 ◽

Cited By ~ 18

Author(s):

F Di Virgilio ◽

T Pozzan ◽

C B Wollheim ◽

L M Vicentini ◽

J Meldolesi

Keyword(s):

Cell Lines ◽

Phorbol Myristate Acetate ◽

Secretory Cell ◽

Tumor Promoter ◽

Myristate Acetate ◽

Voltage Gated ◽

Ca2 Channels

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Inhibition by verapamil of neutrophil responses to formylmethionylleucylphenylalanine and phorbol myristate acetate. Mechanisms involving Ca2+ changes, cyclic AMP and protein kinase C

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research ◽

10.1016/0167-4889(85)90180-6 ◽

1985 ◽

Vol 845 (2) ◽

pp. 223-236 ◽

Cited By ~ 22

Author(s):

Vittorina Della Bianca ◽

Miroslawa Grzeskowiak ◽

Pietro De Togni ◽

Marco Cassatella ◽

Filippo Rossi

Keyword(s):

Protein Kinase C ◽

Protein Kinase ◽

Cyclic Amp ◽

Phorbol Myristate Acetate ◽

Myristate Acetate ◽

Kinase C

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Modification of hepatic protein kinase C with phorbol myristate acetate and staurosporine alters hemodynamics in the perfused rat liver

Journal of Anesthesia ◽

10.1007/s0054030070048 ◽

1993 ◽

Vol 7 (1) ◽

pp. 48-55

Author(s):

Hideo Inaba ◽

Masahiko Araki ◽

Takeshi Numai ◽

Tadanobu Mizuguchi

Keyword(s):

Protein Kinase C ◽

Protein Kinase ◽

Rat Liver ◽

Phorbol Myristate Acetate ◽

Perfused Rat Liver ◽

Myristate Acetate ◽

Kinase C

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Expression of adhesion molecules on cord-blood-derived, cultured human mast cells and effect of dexamethasone on intercellular adhesion molecule-1 expression on the mast cells treated by phorbol myristate acetate

Allergy ◽

10.1034/j.1398-9995.2001.00001.x-i1 ◽

2001 ◽

Vol 56 (7) ◽

pp. 672-678

Author(s):

H. Inamura ◽

M. Kurosawa ◽

T. Kuwasaki ◽

Y. Kamada ◽

H. Kayaba ◽

...

Keyword(s):

Mast Cells ◽

Cord Blood ◽

Adhesion Molecules ◽

Adhesion Molecule ◽

Phorbol Myristate Acetate ◽

Intercellular Adhesion ◽

Intercellular Adhesion Molecule ◽

Myristate Acetate ◽

Intercellular Adhesion Molecule 1 ◽

Human Mast Cells

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Effects of thrombin, phorbol myristate acetate and prostaglandin D2 on 40-41 kDa protein that is ADP ribosylated by pertussis toxin in platelets

FEBS Letters ◽

10.1016/0014-5793(86)80840-7 ◽

1986 ◽

Vol 204 (2) ◽

pp. 341-346 ◽

Cited By ~ 34

Author(s):

Stephen P. Halenda ◽

Mario Volpi ◽

George B. Zavoico ◽

Ramadan I. Sha'afi ◽

Maurice B. Feinstein

Keyword(s):

Phorbol Myristate Acetate ◽

Pertussis Toxin ◽

Prostaglandin D2 ◽

Myristate Acetate

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Identification of Early Growth Response Gene-1 (Egr-1) as a Phorbol Myristate Acetate-induced Gene in Lung Cancer Cells by Differential mRNA Display

American Journal of Respiratory Cell and Molecular Biology ◽

10.1165/ajrcmb.17.5.2843 ◽

1997 ◽

Vol 17 (5) ◽

pp. 617-624 ◽

Cited By ~ 6

Author(s):

Liang You ◽

Sonia B. Jakowlew

Keyword(s):

Lung Cancer ◽

Cancer Cells ◽

Phorbol Myristate Acetate ◽

Growth Response ◽

Early Growth ◽

Myristate Acetate ◽

Response Gene ◽

Early Growth Response ◽

Early Growth Response Gene ◽

Differential Mrna Display

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Down-regulation followed by re-expression of equine CD4 molecules in response to phorbol myristate acetate

Veterinary Immunology and Immunopathology ◽

10.1016/0165-2427(94)90090-6 ◽

1994 ◽

Vol 42 (1) ◽

pp. 71-82 ◽

Cited By ~ 6

Author(s):

C.H. Zhang ◽

G. Grünig ◽

W. Davis ◽

D.F. Antczak

Keyword(s):

Phorbol Myristate Acetate ◽

Myristate Acetate ◽

Down Regulation

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Factors which affect DNA strand breakage in human leukocytes exposed to a tumor promoter, phorbol myristate acetate

Canadian Journal of Physiology and Pharmacology ◽

10.1139/y82-203 ◽

1982 ◽

Vol 60 (11) ◽

pp. 1359-1366 ◽

Cited By ~ 36

Author(s):

H. C. Birnboim

Keyword(s):

Hydrogen Peroxide ◽

Dna Damage ◽

Phorbol Myristate Acetate ◽

Respiratory Burst ◽

Superoxide Anion ◽

Tumor Promoter ◽

Myristate Acetate ◽

Strand Breakage ◽

Dna Strand ◽

Dna Strand Breakage

We have recently reported that phorbol myristate acetate (PMA) induces extensive DNA strand break damage in human peripheral blood leukocytes. The mechanism of action involves superoxide anion and hydrogen peroxide which are generated by phagocytes during the "respiratory burst." In this report, we describe the effect of various inhibitors and scavengers on PMA-induced DNA damage. Azide and cyanide greatly increased the level of damage; sulfhydryl compounds (glutathione, cysteine, and cysteamine) and ascorbate markedly decreased the level of damage. Hydroxyl radical scavengers such as dimethyl sulfoxide (DMSO) and glycerol also decreased the level of damage but apparently did so by inhibiting the respiratory burst. Diethyldithiocarbamate (DDC) increased the level of DNA damage at low concentrations (<1 mM), but decreased DNA damage at ≥1 mM. The results are consistent with a mechanism involving superoxide anion and hydrogen peroxide, but the precise reaction (free radical or enzymatic) responsible for DNA strand breakage has not been determined. The PMA-stimulated phagocyte is an interesting model system for looking at "active oxygen" mediated DNA damage and factors which influence it.

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