Athymic Nude Rats

1981 ◽  
pp. 267-283 ◽  
Author(s):  
Michael F. W. Festing
Keyword(s):  
Nude Rats

Xenotransplantation of whole pig ovaries into nude rats as an experimental model for fertility preservation

2014 ◽  
Vol 74 (S 01) ◽  
Author(s):  
R Dittrich ◽  
L Lotz ◽  
S Nichols-Burns ◽  
H Schneider ◽  
I Hoffmann ◽  
...  
Keyword(s):  
Fertility Preservation ◽  
Experimental Model ◽  
Nude Rats

ALLOGRAFT REJECTION IN ATHYMIC NUDE RATS BY TRANSFERRED T CELL SUBSETS

1990 ◽  
Vol 50 (4) ◽  
pp. 690-695 ◽  
Author(s):  
ERIC B. BELL ◽  
DARIUSH REJALI ◽  
ELSPETH H. WHITBY ◽  
SHEILA M. SPARSHOTT ◽  
CHUN-PING YANG
Keyword(s):  
T Cell ◽  
Allograft Rejection ◽  
T Cell Subsets ◽  
Nude Rats

Minimal Engraftment of Human CD34+Cells Mobilized From Healthy Donors in the Infarcted Heart of Athymic Nude Rats

2009 ◽  
Vol 18 (6) ◽  
pp. 845-856 ◽  
Author(s):  
Claus S. Sondergaard ◽  
Jesper Bonde ◽  
Frederik Dagnæs-Hansen ◽  
Jan M. Nielsen ◽  
Vladimir Zachar ◽  
...  
Keyword(s):  
Human Cd34 ◽  
Infarcted Heart ◽  
Nude Rats ◽  
Healthy Donors ◽  
Cd34 Cells

Upregulation of MicroRNA-199 (miR-199) Prompts the Apoptosis of K562 Cell in the Model of Mice with Leukemia

2021 ◽  
Vol 11 (7) ◽  
pp. 1383-1387
Author(s):  
Jijun Hu ◽  
Zongshen Rao ◽  
Min Luo ◽  
Xiangyou Li
Keyword(s):  
Therapeutic Target ◽  
K562 Cell ◽  
Cell Activity ◽  
Myeloid Cells ◽  
Leukemia Cells ◽  
Control Group ◽  
Blank Control Group ◽  
Blank Group ◽  
Nude Rats

We investigated miR-199’s effect on the apoptosis of leukemia cells (K562) as so to provide reference idea for a new therapeutic target. 20 normal and healthy BALB/c nude rats were selected and equally and randomly assigned into inoculated group and blank group. The K562 cell was obtained and then divided into blank control group, miR-199 mimic group, and miR-199NC group followed by analysis of miR-199 expression, cell activity and apoptosis as well as the expression of Bax, Bcl-2 and PCNA. Inoculated group showed significantly higher proportion of leukemia cells and myeloid cells than blank group. The expression of miR-199 (3.22±0.03) in miR-199 mimic group was significantly higher than other two groups (P < 0.05) without difference between other two groups (P > 0.05). Bax expression (1.16±0.10) in miR-199 mimic group was significantly higher, whereas Bcl-2 (0.02±0.01) and PCNA (0.47±0.05) expression was significantly lower than other two groups. Upregulation of miR-199 could restrain the expression of Bcl-2 and PCNA through upregulation of Bax, indicating that miR-199 might be a new therapeutic target.

Adoptive transfer of cloned T helper cells ameliorates periodontal disease in nude rats

1994 ◽  
Vol 9 (5) ◽  
pp. 284-289 ◽  
Author(s):  
J. W. Eastcott ◽  
K. Yamashita ◽  
M. A. Taubman ◽  
Y. Harada ◽  
D. J. Smith
Keyword(s):  
Periodontal Disease ◽  
Adoptive Transfer ◽  
T Helper Cells ◽  
T Helper ◽  
Helper Cells ◽  
Nude Rats

Human mesenchymal progenitor cells induce arteriogenesis and cardiac regeneration following acute ischemia in irradiated nude rats

2005 ◽  
Vol 24 (2) ◽  
pp. S98
Author(s):  
T.P. Martens ◽  
M.D. Schuster ◽  
F.H. Cheema ◽  
F. See ◽  
V.K. Topkara ◽  
...  
Keyword(s):  
Progenitor Cells ◽  
Cardiac Regeneration ◽  
Acute Ischemia ◽  
Mesenchymal Progenitor Cells ◽  
Nude Rats

scholarly journals Nephrotoxic serum nephritis in nude rats: the roles of host immune reactions

2008 ◽  
Vol 84 (1) ◽  
pp. 139-144 ◽  
Author(s):  
T. SATO ◽  
T. OITE ◽  
M. NAGASE ◽  
F. SHIMIZU
Keyword(s):  
Immune Reactions ◽  
Nephrotoxic Serum Nephritis ◽  
Nude Rats

Characterization of an intraperitoneal ovarian cancer xenograft model in nude rats using noninvasive microPET imaging

2007 ◽  
Vol 17 (2) ◽  
pp. 407-417 ◽  
Author(s):  
C. L. Zavaleta ◽  
W. T. Phillips ◽  
Y. C. Bradley ◽  
L. M. McMANUS ◽  
P. A. Jerabek ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Lymph Nodes ◽  
Peritoneal Cavity ◽  
Imaging Modality ◽  
Xenograft Model ◽  
Tumor Model ◽  
Fdg Uptake ◽  
Tumor Bearing ◽  
Nude Rats ◽  
Biodistribution Data

MicroPET is a noninvasive imaging modality that can potentially track tumor development in nude rats using the radiotracer fluorine 18-fluorodeoxyglucose (18F-FDG). Our goal was to determine whether microPET, as opposed to more invasive techniques, could be used to noninvasively monitor the development of ovarian cancer in the peritoneal cavity of nude rats for monitoring treatment response in future studies. Female nude rats were inoculated intraperitoneally with 36 million NIH:OVCAR-3 cells. Imaging was carried out at 2, 4, 6, or 8 weeks postinoculation. Each rat was fasted overnight and intravenously injected with 11.1 MBq (300 μCi) of 18F-FDG in 0.2 mL of saline. Thirty minutes following injection, the rats were placed in the microPET and scanned for 30 min. After imaging, rats were euthanized for ascites and tissue collection for biodistribution and histopathologic correlation. Standard uptake values (SUVs) of 18F-FDG within the peritoneal cavity were also calculated from regions of interest analysis of the microPET images. MicroPET images showed diffuse increased uptake of 18F-FDG throughout the peritoneal cavity of tumor rats (mean SUV = 4.64) compared with control rats (mean SUV = 1.03). Ascites gathered from tumor-bearing rats had increased 18F-FDG uptake as opposed to the peritoneal fluid collected from control rats. Biodistribution data revealed that the percent injected dose per gram (% ID/g) was significantly higher in tumor-bearing rats (6.29%) than in control rats (0.59%) in the peritoneal lymph nodes. Pathology verified that these lymph nodes were more reactive in tumor-bearing rats. By 6 weeks, some rats developed solid masses within the peritoneum, which could be detected on microPET images and confirmed as tumor by histopathology. 18F-FDG uptake in these tumors at necropsy was 2.83% ID/g. These results correlate with previous invasive laparoscopic studies of the same tumor model and demonstrate that microPET using 18F-FDG is a promising noninvasive tool to localize and follow tumor growth in an intraperitoneal ovarian cancer model.

Nephrotoxic Serum Nephritis in Nude Rats: The Role of Cell-Mediated Immunity

Nephron ◽  
1994 ◽  
Vol 68 (3) ◽  
pp. 360-365 ◽  
Author(s):  
T. Kuroda ◽  
K. Kawasaki ◽  
T. Oite ◽  
M. Arakawa ◽  
F. Shimizu
Keyword(s):  
Cell Mediated Immunity ◽  
Nephrotoxic Serum Nephritis ◽  
Nude Rats
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