Immunologic and Hematologic Deficiencies of the Hypopituitary Dwarf Mouse

Author(s):  
Rene J. Duquesnoy ◽  
Grete M. Pedersen
Keyword(s):  
2013 ◽  
Vol 69 (8) ◽  
pp. 923-933 ◽  
Author(s):  
V. L. Armstrong ◽  
S. Rakoczy ◽  
L. Rojanathammanee ◽  
H. M. Brown-Borg

1980 ◽  
Vol 85 (1) ◽  
pp. 35-47 ◽  
Author(s):  
A. T. HOLDER ◽  
M. WALLIS ◽  
P. BIGGS ◽  
M. A. PREECE

SUMMARY Hypopituitary dwarf mice were found to have reduced levels of serum somatomedin-like activity compared with normal mice of the Snell strain. Treatment with bovine growth hormone for 3 and 7 days resulted in growth without significantly increased levels of serum somatomedin-like activity, as detected by in-vitro uptake of 35SO42− into normal rat cartilage; only after treatment for 14 days was somatomedin activity significantly raised. However, treatment for 2 days with bovine growth hormone, bovine prolactin or thyroxine resulted in a dose-dependent increase in in-vivo uptake of 35SO42− into dwarf mouse costal cartilage; growth hormone and thyroxine did not act synergistically. Ten days of treatment with growth hormone promoted a dose-dependent increase in both growth (increased weight gain and tail length) and in-vivo uptake of 35SO42−. Increase in tail length was correlated with uptake of 35SO42−. Thus, in-vivo uptake of 35SO42− into dwarf mouse costal cartilage provides a sensitive method for detecting a dose-related effect of growth hormone.


Endocrinology ◽  
1978 ◽  
Vol 103 (5) ◽  
pp. 1590-1596 ◽  
Author(s):  
RICHARD A. KNAZEK ◽  
SUE C. LIU ◽  
ROBERT L. GRAETER ◽  
PHILIP C. WRIGHT ◽  
JANINE R. MAYER ◽  
...  

1985 ◽  
Vol 10 (6) ◽  
pp. 767-778 ◽  
Author(s):  
Tetsuro Sugisaki ◽  
Tetsuya Noguchi ◽  
Yasuzo Tsukada
Keyword(s):  

Aging Cell ◽  
2010 ◽  
Vol 9 (1) ◽  
pp. 1-18 ◽  
Author(s):  
David J. Bates ◽  
Na Li ◽  
Ruqiang Liang ◽  
Harshini Sarojini ◽  
Jin An ◽  
...  

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