Age-Related Changes of Cells Involved in Immune Responses

1975 ◽  
pp. 315-322
Author(s):  
G. M. Butenko ◽  
A. F. Andrianova
Keyword(s):  
Immune Responses ◽  
Age Related ◽  
Age Related Changes

Longitudinal studies on human schistosomiasis

1988 ◽  
Vol 321 (1207) ◽  
pp. 495-511 ◽  
Keyword(s):  
Immune Responses ◽  
Acquired Resistance ◽  
Acquired Immunity ◽  
Contaminated Water ◽  
Older Individuals ◽  
Human Schistosomiasis ◽  
Slow Development ◽  
Age Related ◽  
Slow Decline ◽  
Age Related Changes

A major difficulty in understanding the epidemiology of human schistosomiasis has been to distinguish between acquired immunity and reduced exposure as possible reasons for an observed decline, in older individuals, of levels of superinlection or of reinfection after chemotherapy. A series of studies of Schistosoma mansoni infections in Kenya has been undertaken to approach this problem, by investigation of intensities of reinfection after treatment of individuals whose levels of contact with contaminated water is subsequently observed. Intensities of reinfection are highest among younger children, thereafter declining sharply. This decline can be attributed only in part to age-related changes in the duration and nature of exposure; there is also evidence for the development of an acquired resistance to reinfection that is dependent both on age and on previous experience of infection, and that may be immunologically mediated. Evidence has been obtained that the slow development of this acquired immunity with age may be associated with the early development and subsequent slow decline of inappropriate immune responses that ‘block' the effect of potentially protective responses. Implications of these findings for immunological intervention through vaccination are discussed.

scholarly journals Social effects on age-related and sex-specific immune cell profiles in a wild mammal

2019 ◽  
Author(s):  
Sil H. J. van Lieshout ◽  
Elisa Perez Badas ◽  
Michael W.T. Mason ◽  
Chris Newman ◽  
Christina D. Buesching ◽  
...  
Keyword(s):  
Immune Responses ◽  
Social Environment ◽  
Immune Cell ◽  
Meles Meles ◽  
Wild Mammal ◽  
Age Related ◽  
In The Wild ◽  
The Individual ◽  
The Impact ◽  
Age Related Changes

Evidence for age-related changes in innate and adaptive immune responses is increasing in wild populations. Such changes have been linked to fitness, and understanding the factors driving variation in immune responses is important for the evolution of immunity and senescence. Age-related changes in immune profiles may be due to sex-specific behaviour, physiology and responses to environmental conditions. Social conditions may also contribute to variation in immunological responses, for example, through transmission of pathogens and stress from resource and mate competition. Yet, the impact of the social environment on age-related changes in immune cell profile requires further investigation in the wild. Here, we tested the relationship between leukocyte cell composition (agranulocyte proportion, i.e. adaptive and innate immunity) and age, sex, and group size in a wild population of European badgers (Meles meles). We found that the proportion of agranulocytes decreased with age only in males living in small groups. In contrast, females in larger groups exhibited a greater age-related decline in the proportion of agranulocytes compared to females in smaller groups. Our results provide evidence for age-related changes in immune cell profiles in a wild mammal, which are influenced by both the sex of the individual and their social environment.

Age Impacts the Local Immune Response to Tuberculin Skin Challenge in Mycobacterium Bovis BCG-vaccinated Baboons

2020 ◽  
Author(s):  
Julia Marianna Scordo ◽  
Tucker J. Piergallini ◽  
Nicole D Reuter ◽  
Colwyn A. Headley ◽  
Vida L. Hodara ◽  
...  
Keyword(s):  
Immune Responses ◽  
Mycobacterium Bovis ◽  
Peripheral Blood ◽  
The Elderly ◽  
Short Term ◽  
Post Vaccination ◽  
Age Related ◽  
Age Related Changes

Abstract Background - Individuals over the age of 65 are highly susceptible to infectious diseases, which account for one-third of deaths in this age group. Vaccines are a primary tool to combat infection, yet they are less effective in the elderly population. While many groups have aimed to address this problem by studying vaccine-induced peripheral blood responses in the elderly, work from our lab and others demonstrate that immune responses to vaccination and infectious challenge may differ between tissue sites and the periphery. To improve health outcomes in our aged population, we must study vaccine responses in the tissue. Here we established an in vivo delayed-type hypersensitivity model of Mycobacterium bovis BCG vaccination and tuberculin skin test (TST) in adult and aged baboons. Vaccination generates BCG-specific immune cells that are recruited to the skin upon tuberculin challenge. We tested short-term recall responses (8 weeks post-vaccination) and long term recall responses (25 weeks post-vaccination) by performing skin punch biopsies around the site of tuberculin injection. In parallel, we determined BCG-induced responses in the peripheral blood of vaccinated animals. Results - In short term recall responses, we found increased oxidation and decreased production of immune proteins in aged baboon skin at the site of TST challenge, in comparison to adult skin. Differences between adult and aged animals normalized in the long term response to tuberculin. Phenotypic analysis of aged peripheral blood cells found several age-related changes in immune cell populations, independent of BCG vaccination, and no impairment in functional responses. Moreover, aged peripheral blood mononuclear cells had increased migration in vitro, suggesting that age-related changes in the tissue in vivo impairs aged immune recall responses to antigenic challenge. Conclusions - These findings highlight the impact of age-associated changes in the local tissue environment in memory recall responses, which may be more broadly applied to the study of other tissues. Moreover, these findings should be considered in future studies aimed at understanding and improving aging immune responses to vaccination and tissue challenge.

Age-related changes of the 3′APOB-VNTR genotype pool in ageing cohorts

1998 ◽  
Vol 62 (2) ◽  
pp. 115-122 ◽  
Author(s):  
G. De BENEDICTIS ◽  
L. CAROTENUTO ◽  
G. CARRIERI ◽  
M. De LUCA ◽  
E. FALCONE ◽  
...  
Keyword(s):  
Age Related ◽  
Age Related Changes

Age-Related Changes in Flexible Listening: Studies on Meta-Audition and the False Hearing Effect

2012 ◽  
Author(s):  
Chad S. Rogers ◽  
Larry L. Jacoby ◽  
Mitchell S. Sommers ◽  
Arthur Wingfield
Keyword(s):  
Age Related ◽  
Listening Studies ◽  
Age Related Changes
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