Changes in Apparent Functions of Component Proteins of Adenylate Cyclase System in Rat Brain by Drugs Acting on the Central Nervous System

1988 ◽  
pp. 287-299 ◽  
Author(s):  
S. Ishibashi ◽  
T. Kurokawa ◽  
T. Dan’ura ◽  
A. Yamashita
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Adenylate Cyclase ◽  
Rat Brain ◽  
Adenylate Cyclase System ◽  
The Central Nervous System

EFFECT OF SEROTONIN AND NEUROPEPTIDES ON ADENYLATE CYCLASE OF THE CENTRAL NERVOUS SYSTEM AND PERIPHERAL ORGANS OF THE FRESHWATER SNAIL PLANORBARIUS CORNEUS

1996 ◽  
Vol 28 (4) ◽  
pp. 417-424 ◽  
Author(s):  
MARIA ENRICA FERRETTI ◽  
DARIO SONETTI ◽  
MARIA CRISTINA PARESCHI ◽  
MARCO BUZZI ◽  
MARIA LUISA COLAMUSSI ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Adenylate Cyclase ◽  
Freshwater Snail ◽  
Planorbarius Corneus ◽  
Peripheral Organs ◽  
The Central Nervous System

scholarly journals Intracellular distribution of pentobarbital sodium in rat brain

1958 ◽  
Author(s):  
◽  
Carol Jean Oen
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Rat Brain ◽  
Major Effect ◽  
Cellular Component ◽  
Intracellular Distribution ◽  
Brain Cells ◽  
Pentobarbital Sodium ◽  
The Central Nervous System ◽  
The Way

"The major effect of the barbiturates is depression of the central nervous system, but the way in which these drugs exert their effect is not yet well understood...As the biochemical functions of the cell and its various parts become better understood, it is of interest to relate the actions of t a drug to some particular function (Reiner and Gellhorn, 1956). If it were found that barbiturate were localized by a particular cellular component, this might mean that its effect was rendered through some function of that particular component. Consequently, this study was undertaken to determine the intracellular distribution of a particular barbiturate, pentobarbital sodium, within rat brain cells."--Introduction

Imidazo[1,2-b]pyridazines. XIII. Syntheses and Central Nervous System Activities of Some 2-Benzyl(phenethyl, biphenyl-4'-yl, 6'-methylnaphthalen-2'-yl, t-Butyl and cyclohexyl)-3-methoxy(acylaminomethyl and dimethylaminomethyl)-6-(variously substituted)imidazo[1,2-b]pyridazines

1992 ◽  
Vol 45 (8) ◽  
pp. 1281 ◽  
Author(s):  
GB Barlin ◽  
LP Davies ◽  
SJ Ireland ◽  
JK Zhang
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Rat Brain ◽  
Brain Membrane ◽  
The Central Nervous System

6-(Variously substituted)-3-methoxy(unsubstituted, dimethylaminomethyl, acetamidomethyl and benzamidomethy1)-2-benzyl(phenethyl, biphenyl-4'-yl, 6'-methylnaphthalen-2'-yl, t-butyl and cyclohexyl)imidazo[1,2-b] pyridazines have been prepared and examined for activity in the central nervous system. Of these, 2-benzyl-3-methoxy-6-(3'-methoxybenzylamino) imidazo[1,2-b]pyridazine (IC50 88nM) bound most strongly to rat brain membrane. In general, the order of activity for groups at the 2-position was Ph > PhCH2 > PhCH2CH2 > C6H4Ph-p, 6'-methylnaphthalen-2'-yl, c-C6H11 or But.

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